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- W2010395976 abstract "Oligodendrocyte (OLG) death plays a major role in white matter dysfunction and demyelination following injury to the CNS. Axonal contact, communication, and neuronal activity appear to promote OLG survival and function in cell culture and during development. The application of electrical stimulation to mixed neural cultures has been shown to promote OLG differentiation and the formation of myelin in vitro. Here we show that OLG viability can be significantly enhanced in mixed cortical cultures by applying biphasic pulses of electrical stimulation (ESTIM). Enhanced survival via ESTIM requires the presence of neurons and is suppressed by inhibition of voltage-gated sodium channels. Additionally, contact between the axon and OLG is necessary for ESTIM to promote OLG survival. This report suggests that patterned neuronal activity could repress delayed progression of white matter injury and promote CNS repair in neurological conditions that involve white matter damage. Journal of Neuroscience Research (2011) © 2011 Wiley Periodicals, Inc." @default.
- W2010395976 created "2016-06-24" @default.
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- W2010395976 date "2011-09-19" @default.
- W2010395976 modified "2023-09-25" @default.
- W2010395976 title "Electrical stimulation promotes the survival of oligodendrocytes in mixed cortical cultures" @default.
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- W2010395976 cites W1568440737 @default.
- W2010395976 cites W1621337337 @default.
- W2010395976 cites W1631348406 @default.
- W2010395976 cites W1728141861 @default.
- W2010395976 cites W1896146290 @default.
- W2010395976 cites W1907724378 @default.
- W2010395976 cites W1915062990 @default.
- W2010395976 cites W1978225369 @default.
- W2010395976 cites W1982518697 @default.
- W2010395976 cites W1983763140 @default.
- W2010395976 cites W1984699355 @default.
- W2010395976 cites W1984881798 @default.
- W2010395976 cites W1987284219 @default.
- W2010395976 cites W1987658639 @default.
- W2010395976 cites W1988983571 @default.
- W2010395976 cites W1992643337 @default.
- W2010395976 cites W1992882873 @default.
- W2010395976 cites W1999379822 @default.
- W2010395976 cites W2002844771 @default.
- W2010395976 cites W2004984177 @default.
- W2010395976 cites W2005533458 @default.
- W2010395976 cites W2008344394 @default.
- W2010395976 cites W2008720843 @default.
- W2010395976 cites W2009678341 @default.
- W2010395976 cites W2012814330 @default.
- W2010395976 cites W2016319161 @default.
- W2010395976 cites W2018767861 @default.
- W2010395976 cites W2020315449 @default.
- W2010395976 cites W2020669012 @default.
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- W2010395976 cites W2035012826 @default.
- W2010395976 cites W2040611959 @default.
- W2010395976 cites W2050051946 @default.
- W2010395976 cites W2055878329 @default.
- W2010395976 cites W2067729717 @default.
- W2010395976 cites W2070749396 @default.
- W2010395976 cites W2075266360 @default.
- W2010395976 cites W2076629321 @default.
- W2010395976 cites W2078812469 @default.
- W2010395976 cites W2078956121 @default.
- W2010395976 cites W2081964652 @default.
- W2010395976 cites W2089543497 @default.
- W2010395976 cites W2092906280 @default.
- W2010395976 cites W2095040041 @default.
- W2010395976 cites W2102532330 @default.
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- W2010395976 doi "https://doi.org/10.1002/jnr.22717" @default.
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