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- W2010396356 abstract "We performed [ 18 F]6-fluoro-L-dopa (6-FD) and[ 11 C]raclopride (RAC) PET studies in six patients with Machado-Joseph disease (MJD) (age, 17 to 61 years; duration of illness, 3 to 10 years), normal controls (n = 10 in 6-FD-PET, n = 8 in RAC-PET), and patients with idiopathic parkinsonism (n = 15 in 6-FD-PET). The youngest patient with MJD had prominent dystonia and pyramidal features (type 1 MJD), whereas the remainder were prominently ataxic (types 2 and 3 MJD). Striatal RAC binding was normal in patients with MJD. Striatal 6-FD influx constants (Ki) were low in the range of idiopathic parkinsonism in two patients with MJD (youngest and oldest patients), whereas striatal Ki were normal in the remaining patients with MJD. The impairment of the nigrostriatal dopaminergic pathway did not correlate with the phenotype, CAG repeat length, disease duration, or age of onset patients with MJD. Our results suggest that striatal D2 receptor are normal and the nigral damage is diverse in MJD." @default.
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- W2010396356 date "1997-10-01" @default.
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- W2010396356 title "Fluorodopa and raclopride PET analysis of patients with Machado-Joseph disease" @default.
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- W2010396356 doi "https://doi.org/10.1212/wnl.49.4.1133" @default.
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