FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010400461> ?p ?o ?g. }

• W2010400461 endingPage "7044" @default.
• W2010400461 startingPage "7032" @default.
• W2010400461 abstract "ABSTRACT MetR (formerly Smu.1225), a regulator of the LysR family, controls key genes for methionine supply in Streptococcus mutans . An S. mutans metR mutant is unable to transport l -methionine and to grow in the absence of this amino acid. Accordingly, MetR activates transcription by binding to the promoter regions of two gene clusters and smu.1487, whose products are involved in methionine biosynthesis (MetEF and Smu.1487) and uptake (AtmBDE). Transcriptional activation by MetR requires the presence of a 17-bp palindromic sequence, the Met box. Base substitutions in the Met box hinder the formation of a MetR-DNA complex and abolish MetR-dependent activation, showing that Met boxes correspond to MetR recognition sites. Activation by MetR occurs in methionine-depleted medium and is rapidly triggered under nonactivating conditions by the addition of homocysteine. This intermediate of methionine biosynthesis increases the affinity of MetR for DNA in vitro and appears to be the MetR coeffector in vivo. Homocysteine plays a crucial role in methionine metabolic gene regulation by controlling MetR activity. A similar mechanism of homocysteine- and MetR-dependent control of methionine biosynthetic genes operates in S. thermophilus . These data suggest a common mechanism for the regulation of the methionine supply in streptococci. However, some streptococcal species are unable to synthesize the homocysteine coeffector. This intriguing feature is discussed in the light of comparative genomics and streptococcal ecology." @default.
• W2010400461 created "2016-06-24" @default.
• W2010400461 creator A5000482298 @default.
• W2010400461 creator A5001709394 @default.
• W2010400461 creator A5039876748 @default.
• W2010400461 creator A5051011688 @default.
• W2010400461 creator A5073982023 @default.
• W2010400461 creator A5077362627 @default.
• W2010400461 creator A5089264945 @default.
• W2010400461 date "2007-10-01" @default.
• W2010400461 modified "2023-09-30" @default.
• W2010400461 title "Control of Methionine Synthesis and Uptake by MetR and Homocysteine in <i>Streptococcus mutans</i>" @default.
• W2010400461 cites W1525240212 @default.
• W2010400461 cites W1588939646 @default.
• W2010400461 cites W1597988523 @default.
• W2010400461 cites W1677985623 @default.
• W2010400461 cites W1688535579 @default.
• W2010400461 cites W1809685151 @default.
• W2010400461 cites W1863358690 @default.
• W2010400461 cites W1899848340 @default.
• W2010400461 cites W1952781471 @default.
• W2010400461 cites W1964054658 @default.
• W2010400461 cites W1969229800 @default.
• W2010400461 cites W1979431512 @default.
• W2010400461 cites W1986173091 @default.
• W2010400461 cites W1990323108 @default.
• W2010400461 cites W1991941799 @default.
• W2010400461 cites W2002276562 @default.
• W2010400461 cites W2007273534 @default.
• W2010400461 cites W2008697605 @default.
• W2010400461 cites W2021053132 @default.
• W2010400461 cites W2049474456 @default.
• W2010400461 cites W2050078027 @default.
• W2010400461 cites W2053264108 @default.
• W2010400461 cites W2060027466 @default.
• W2010400461 cites W2070232229 @default.
• W2010400461 cites W2087376852 @default.
• W2010400461 cites W2090978910 @default.
• W2010400461 cites W2101849873 @default.
• W2010400461 cites W2103083719 @default.
• W2010400461 cites W2113220951 @default.
• W2010400461 cites W2113422317 @default.
• W2010400461 cites W2116919597 @default.
• W2010400461 cites W2123022819 @default.
• W2010400461 cites W2124094019 @default.
• W2010400461 cites W2125116820 @default.
• W2010400461 cites W2128284350 @default.
• W2010400461 cites W2135830076 @default.
• W2010400461 cites W2142639150 @default.
• W2010400461 cites W2147383244 @default.
• W2010400461 cites W2148826598 @default.
• W2010400461 cites W2152523980 @default.
• W2010400461 cites W2157947948 @default.
• W2010400461 cites W2162270797 @default.
• W2010400461 cites W2162981811 @default.
• W2010400461 cites W2177832086 @default.
• W2010400461 cites W2210919387 @default.
• W2010400461 doi "https://doi.org/10.1128/jb.00703-07" @default.
• W2010400461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045202" @default.
• W2010400461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17675375" @default.
• W2010400461 hasPublicationYear "2007" @default.
• W2010400461 type Work @default.
• W2010400461 sameAs 2010400461 @default.
• W2010400461 citedByCount "54" @default.
• W2010400461 countsByYear W20104004612012 @default.
• W2010400461 countsByYear W20104004612013 @default.
• W2010400461 countsByYear W20104004612014 @default.
• W2010400461 countsByYear W20104004612015 @default.
• W2010400461 countsByYear W20104004612016 @default.
• W2010400461 countsByYear W20104004612017 @default.
• W2010400461 countsByYear W20104004612018 @default.
• W2010400461 countsByYear W20104004612019 @default.
• W2010400461 countsByYear W20104004612020 @default.
• W2010400461 countsByYear W20104004612021 @default.
• W2010400461 countsByYear W20104004612022 @default.
• W2010400461 countsByYear W20104004612023 @default.
• W2010400461 crossrefType "journal-article" @default.
• W2010400461 hasAuthorship W2010400461A5000482298 @default.
• W2010400461 hasAuthorship W2010400461A5001709394 @default.
• W2010400461 hasAuthorship W2010400461A5039876748 @default.
• W2010400461 hasAuthorship W2010400461A5051011688 @default.
• W2010400461 hasAuthorship W2010400461A5073982023 @default.
• W2010400461 hasAuthorship W2010400461A5077362627 @default.
• W2010400461 hasAuthorship W2010400461A5089264945 @default.
• W2010400461 hasBestOaLocation W20104004612 @default.
• W2010400461 hasConcept C2777090595 @default.
• W2010400461 hasConcept C2780912031 @default.
• W2010400461 hasConcept C515207424 @default.
• W2010400461 hasConcept C54355233 @default.
• W2010400461 hasConcept C55493867 @default.
• W2010400461 hasConcept C80315684 @default.
• W2010400461 hasConcept C86803240 @default.
• W2010400461 hasConceptScore W2010400461C2777090595 @default.
• W2010400461 hasConceptScore W2010400461C2780912031 @default.
• W2010400461 hasConceptScore W2010400461C515207424 @default.
• W2010400461 hasConceptScore W2010400461C54355233 @default.
• W2010400461 hasConceptScore W2010400461C55493867 @default.
• W2010400461 hasConceptScore W2010400461C80315684 @default.

• next