Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010400502> ?p ?o ?g. }
- W2010400502 endingPage "2531" @default.
- W2010400502 startingPage "2523" @default.
- W2010400502 abstract "Abstract In immortal cells, the existence of a mechanism for the maintenance of telomere length is critical. In most cases this is achieved by the reactivation of telomerase, a cellular reverse transcriptase that prevents telomere shortening. Here we report that the telomerase gene (hTERT) promoter is up-regulated during transmission of human T-cell lymphotropic virus type-I (HTLV-I) to primary T cells in vitro and in ex vivo adult T-cell leukemia/lymphoma (ATLL) samples, but not asymptomatic carriers. Although Tax impaired induction of human telomerase reverse transcriptase (hTERT) mRNA in response to mitogenic stimulation, transduction of Tax into primary lymphocytes was sufficient to activate and maintain telomerase expression and telomere length when cultured in the absence of any exogenous stimulation. Transient transfection assays revealed that Tax stimulates the hTERT promoter through the nuclear factor κB (NF-κB) pathway. Consistently, Tax mutants inactive for NF-κB activation could not activate the hTERT or sustain telomere length in transduced primary lymphocytes. Analysis of the hTERT promoter occupancy in vivo using chromatin immunoprecipitation assays suggested that an increased binding of c-Myc and Sp1 is involved in the NF-κB–mediated activation of the hTERT promoter. This study establishes the role of Tax in regulation of telomerase expression, which may cooperate with other functions of Tax to promote HTLV-I–associated adult T-cell leukemia." @default.
- W2010400502 created "2016-06-24" @default.
- W2010400502 creator A5024552645 @default.
- W2010400502 creator A5025054085 @default.
- W2010400502 creator A5061490428 @default.
- W2010400502 creator A5073296805 @default.
- W2010400502 creator A5073780379 @default.
- W2010400502 creator A5081990518 @default.
- W2010400502 creator A5083237599 @default.
- W2010400502 creator A5085331203 @default.
- W2010400502 creator A5091468913 @default.
- W2010400502 date "2004-10-15" @default.
- W2010400502 modified "2023-09-30" @default.
- W2010400502 title "Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cells" @default.
- W2010400502 cites W1496772673 @default.
- W2010400502 cites W1542367364 @default.
- W2010400502 cites W1544092207 @default.
- W2010400502 cites W1547608553 @default.
- W2010400502 cites W1547769073 @default.
- W2010400502 cites W1568829148 @default.
- W2010400502 cites W1573652663 @default.
- W2010400502 cites W1609984326 @default.
- W2010400502 cites W17654226 @default.
- W2010400502 cites W1972849875 @default.
- W2010400502 cites W1984374449 @default.
- W2010400502 cites W1986265440 @default.
- W2010400502 cites W2001566280 @default.
- W2010400502 cites W2001944699 @default.
- W2010400502 cites W2002761352 @default.
- W2010400502 cites W2002883144 @default.
- W2010400502 cites W2006565381 @default.
- W2010400502 cites W2009761723 @default.
- W2010400502 cites W2013073993 @default.
- W2010400502 cites W2013956239 @default.
- W2010400502 cites W2016292129 @default.
- W2010400502 cites W2027001966 @default.
- W2010400502 cites W2036562203 @default.
- W2010400502 cites W2039040106 @default.
- W2010400502 cites W2039426604 @default.
- W2010400502 cites W2039709545 @default.
- W2010400502 cites W2041675319 @default.
- W2010400502 cites W2046601800 @default.
- W2010400502 cites W2054383392 @default.
- W2010400502 cites W2054391444 @default.
- W2010400502 cites W2055115648 @default.
- W2010400502 cites W2056106902 @default.
- W2010400502 cites W2062772646 @default.
- W2010400502 cites W2064021511 @default.
- W2010400502 cites W2064732318 @default.
- W2010400502 cites W2065973413 @default.
- W2010400502 cites W2072940891 @default.
- W2010400502 cites W2079011320 @default.
- W2010400502 cites W2084414661 @default.
- W2010400502 cites W2084415176 @default.
- W2010400502 cites W2091994700 @default.
- W2010400502 cites W2092174482 @default.
- W2010400502 cites W2093973061 @default.
- W2010400502 cites W2096286890 @default.
- W2010400502 cites W2101060260 @default.
- W2010400502 cites W2107709399 @default.
- W2010400502 cites W2113189884 @default.
- W2010400502 cites W2113300169 @default.
- W2010400502 cites W2117408241 @default.
- W2010400502 cites W2117824620 @default.
- W2010400502 cites W2127573529 @default.
- W2010400502 cites W2133616913 @default.
- W2010400502 cites W2134055375 @default.
- W2010400502 cites W2141704910 @default.
- W2010400502 cites W2144192014 @default.
- W2010400502 cites W2145305345 @default.
- W2010400502 cites W2150788604 @default.
- W2010400502 cites W2153258255 @default.
- W2010400502 cites W2161081336 @default.
- W2010400502 cites W2162007651 @default.
- W2010400502 cites W2164441196 @default.
- W2010400502 cites W2165343463 @default.
- W2010400502 cites W2168298202 @default.
- W2010400502 cites W2170172182 @default.
- W2010400502 cites W2256062038 @default.
- W2010400502 cites W2323754647 @default.
- W2010400502 cites W3213553087 @default.
- W2010400502 doi "https://doi.org/10.1182/blood-2003-12-4251" @default.
- W2010400502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15226182" @default.
- W2010400502 hasPublicationYear "2004" @default.
- W2010400502 type Work @default.
- W2010400502 sameAs 2010400502 @default.
- W2010400502 citedByCount "121" @default.
- W2010400502 countsByYear W20104005022012 @default.
- W2010400502 countsByYear W20104005022013 @default.
- W2010400502 countsByYear W20104005022014 @default.
- W2010400502 countsByYear W20104005022015 @default.
- W2010400502 countsByYear W20104005022016 @default.
- W2010400502 countsByYear W20104005022017 @default.
- W2010400502 countsByYear W20104005022019 @default.
- W2010400502 countsByYear W20104005022020 @default.
- W2010400502 countsByYear W20104005022021 @default.
- W2010400502 countsByYear W20104005022022 @default.
- W2010400502 countsByYear W20104005022023 @default.