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- W2010401910 abstract "Early rectal cancer (ERC) is adenocarcinoma that has invaded into, but not extended beyond, the submucosa of the rectum (that is a T1 tumour). Local excision is curative for low-risk ERCs but for high-risk cancers such management is controversial.This review is based on published literature obtained by searching the PubMed and Cochrane databases, and the bibliographies of extracted articles.ERC presents as a focus of malignancy within an adenoma, as a polyp, or as a small ulcerating adenocarcinoma. Preoperative staging relies on endorectal ultrasonography and magnetic resonance imaging. Pathological staging uses the Haggitt and Kikuchi classifications for adenocarcinoma in pedunculated and sessile polyps respectively. Lymph node metastases increase with the Kikuchi level, with a 1-3 per cent risk for submucosal layer (Sm) 1, 8 per cent for Sm2 and 23 per cent for Sm3 lesions. Low-risk ERCs may be treated endoscopically or by a transanal procedure. Transanal excision or transanal endoscopic microsurgery may be inadequate for high-risk ERCs and adjuvant chemoradiotherapy may be appropriate. There is a low rate of recurrence after local surgery for low-risk ERCs but this increases to up to 29 per cent for high-risk cancers." @default.
- W2010401910 created "2016-06-24" @default.
- W2010401910 creator A5001946031 @default.
- W2010401910 creator A5010038955 @default.
- W2010401910 creator A5068445845 @default.
- W2010401910 date "2008-03-04" @default.
- W2010401910 modified "2023-10-08" @default.
- W2010401910 title "Management of early rectal cancer" @default.
- W2010401910 cites W1567015072 @default.
- W2010401910 cites W1602205611 @default.
- W2010401910 cites W1743647058 @default.
- W2010401910 cites W1963686220 @default.
- W2010401910 cites W1964753576 @default.
- W2010401910 cites W1967715915 @default.
- W2010401910 cites W1968703509 @default.
- W2010401910 cites W1968797858 @default.
- W2010401910 cites W1969967055 @default.
- W2010401910 cites W1970389986 @default.
- W2010401910 cites W1975438658 @default.
- W2010401910 cites W1975991524 @default.
- W2010401910 cites W1977314859 @default.
- W2010401910 cites W1977351090 @default.
- W2010401910 cites W1978042223 @default.
- W2010401910 cites W1979868786 @default.
- W2010401910 cites W1979950674 @default.
- W2010401910 cites W1980393899 @default.
- W2010401910 cites W1981293005 @default.
- W2010401910 cites W1981793688 @default.
- W2010401910 cites W1983211539 @default.
- W2010401910 cites W1986804631 @default.
- W2010401910 cites W1988071481 @default.
- W2010401910 cites W1990683236 @default.
- W2010401910 cites W1992249426 @default.
- W2010401910 cites W1995001362 @default.
- W2010401910 cites W1996196502 @default.
- W2010401910 cites W2001316457 @default.
- W2010401910 cites W2001417274 @default.
- W2010401910 cites W2005764260 @default.
- W2010401910 cites W2005896779 @default.
- W2010401910 cites W2008072720 @default.
- W2010401910 cites W2009124022 @default.
- W2010401910 cites W2009257463 @default.
- W2010401910 cites W2009912942 @default.
- W2010401910 cites W2011537800 @default.
- W2010401910 cites W2012164445 @default.
- W2010401910 cites W2012168848 @default.
- W2010401910 cites W2013580713 @default.
- W2010401910 cites W2013696688 @default.
- W2010401910 cites W2016529135 @default.
- W2010401910 cites W2020767489 @default.
- W2010401910 cites W2021457628 @default.
- W2010401910 cites W2021631690 @default.
- W2010401910 cites W2024283734 @default.
- W2010401910 cites W2024304874 @default.
- W2010401910 cites W2027105006 @default.
- W2010401910 cites W2027112842 @default.
- W2010401910 cites W2027313766 @default.
- W2010401910 cites W2031419723 @default.
- W2010401910 cites W2033887466 @default.
- W2010401910 cites W2034922851 @default.
- W2010401910 cites W2039297428 @default.
- W2010401910 cites W2039648924 @default.
- W2010401910 cites W2040367853 @default.
- W2010401910 cites W2043888168 @default.
- W2010401910 cites W2046005965 @default.
- W2010401910 cites W2046706118 @default.
- W2010401910 cites W2047344407 @default.
- W2010401910 cites W2048742941 @default.
- W2010401910 cites W2051402863 @default.
- W2010401910 cites W2052410312 @default.
- W2010401910 cites W2052659117 @default.
- W2010401910 cites W2054123146 @default.
- W2010401910 cites W2055949217 @default.
- W2010401910 cites W2058612995 @default.
- W2010401910 cites W2064733900 @default.
- W2010401910 cites W2066180869 @default.
- W2010401910 cites W2068055769 @default.
- W2010401910 cites W2068352354 @default.
- W2010401910 cites W2070330597 @default.
- W2010401910 cites W2071426621 @default.
- W2010401910 cites W2073708753 @default.
- W2010401910 cites W2074214186 @default.
- W2010401910 cites W2074703148 @default.
- W2010401910 cites W2078512888 @default.
- W2010401910 cites W2078871137 @default.
- W2010401910 cites W2082160016 @default.
- W2010401910 cites W2083622336 @default.
- W2010401910 cites W2084595299 @default.
- W2010401910 cites W2086326860 @default.
- W2010401910 cites W2087723271 @default.
- W2010401910 cites W2090456766 @default.
- W2010401910 cites W2092848977 @default.
- W2010401910 cites W2094220943 @default.
- W2010401910 cites W2100066812 @default.
- W2010401910 cites W2107982027 @default.
- W2010401910 cites W2110767036 @default.
- W2010401910 cites W2110847198 @default.
- W2010401910 cites W2111157352 @default.