Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010402705> ?p ?o ?g. }
- W2010402705 endingPage "207" @default.
- W2010402705 startingPage "197" @default.
- W2010402705 abstract "Guidance receptors detect extracellular cues and instruct migrating cells how to orient in space. Border cells perform a directional invasive migration during Drosophila oogenesis and use two receptor tyrosine kinases (RTKs), EGFR and PVR (PDGF/VEGF Receptor), to read guidance cues. We find that spatial localization of RTK signaling within these migrating cells is actively controlled. Border cells lacking Cbl, an RTK-associated E3 ubiquitin ligase, have delocalized guidance signaling, resulting in severe migration defects. Absence of Sprint, a receptor-recruited, Ras-activated Rab5 guanine exchange factor, gives related defects. In contrast, increasing the level of RTK signaling by receptor overexpression or removing Hrs and thereby decreasing RTK degradation does not perturb migration. Cbl and Sprint both regulate early steps of RTK endocytosis. Thus, a physiological role of RTK endocytosis is to ensure localized intracellular response to guidance cues by stimulating spatial restriction of signaling." @default.
- W2010402705 created "2016-06-24" @default.
- W2010402705 creator A5001119999 @default.
- W2010402705 creator A5069467026 @default.
- W2010402705 creator A5074137472 @default.
- W2010402705 creator A5087457611 @default.
- W2010402705 date "2005-08-01" @default.
- W2010402705 modified "2023-10-08" @default.
- W2010402705 title "Regulators of Endocytosis Maintain Localized Receptor Tyrosine Kinase Signaling in Guided Migration" @default.
- W2010402705 cites W1571287379 @default.
- W2010402705 cites W1970180329 @default.
- W2010402705 cites W1975721661 @default.
- W2010402705 cites W1975971309 @default.
- W2010402705 cites W1979153707 @default.
- W2010402705 cites W1983096415 @default.
- W2010402705 cites W1984536659 @default.
- W2010402705 cites W1988744406 @default.
- W2010402705 cites W1996487201 @default.
- W2010402705 cites W1996617935 @default.
- W2010402705 cites W1997524493 @default.
- W2010402705 cites W2001442269 @default.
- W2010402705 cites W2006566159 @default.
- W2010402705 cites W2007215986 @default.
- W2010402705 cites W2013673237 @default.
- W2010402705 cites W2019109537 @default.
- W2010402705 cites W2026227107 @default.
- W2010402705 cites W2027533965 @default.
- W2010402705 cites W2029733869 @default.
- W2010402705 cites W2031502846 @default.
- W2010402705 cites W2032516003 @default.
- W2010402705 cites W2036805817 @default.
- W2010402705 cites W2039701501 @default.
- W2010402705 cites W2055786440 @default.
- W2010402705 cites W2057071478 @default.
- W2010402705 cites W2059695583 @default.
- W2010402705 cites W2061472058 @default.
- W2010402705 cites W2062855968 @default.
- W2010402705 cites W2063220206 @default.
- W2010402705 cites W2064316921 @default.
- W2010402705 cites W2070782703 @default.
- W2010402705 cites W2083898995 @default.
- W2010402705 cites W2088013881 @default.
- W2010402705 cites W2095065858 @default.
- W2010402705 cites W2103513673 @default.
- W2010402705 cites W2106626264 @default.
- W2010402705 cites W2112943515 @default.
- W2010402705 cites W2131943106 @default.
- W2010402705 cites W2134557279 @default.
- W2010402705 cites W2142623337 @default.
- W2010402705 cites W2146117749 @default.
- W2010402705 cites W2147534191 @default.
- W2010402705 cites W2153575042 @default.
- W2010402705 cites W2156981424 @default.
- W2010402705 cites W2160300536 @default.
- W2010402705 cites W2166445583 @default.
- W2010402705 cites W2169290377 @default.
- W2010402705 cites W2171857030 @default.
- W2010402705 cites W2185351394 @default.
- W2010402705 doi "https://doi.org/10.1016/j.devcel.2005.06.004" @default.
- W2010402705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16054027" @default.
- W2010402705 hasPublicationYear "2005" @default.
- W2010402705 type Work @default.
- W2010402705 sameAs 2010402705 @default.
- W2010402705 citedByCount "210" @default.
- W2010402705 countsByYear W20104027052012 @default.
- W2010402705 countsByYear W20104027052013 @default.
- W2010402705 countsByYear W20104027052014 @default.
- W2010402705 countsByYear W20104027052015 @default.
- W2010402705 countsByYear W20104027052016 @default.
- W2010402705 countsByYear W20104027052017 @default.
- W2010402705 countsByYear W20104027052018 @default.
- W2010402705 countsByYear W20104027052019 @default.
- W2010402705 countsByYear W20104027052020 @default.
- W2010402705 countsByYear W20104027052021 @default.
- W2010402705 countsByYear W20104027052022 @default.
- W2010402705 countsByYear W20104027052023 @default.
- W2010402705 crossrefType "journal-article" @default.
- W2010402705 hasAuthorship W2010402705A5001119999 @default.
- W2010402705 hasAuthorship W2010402705A5069467026 @default.
- W2010402705 hasAuthorship W2010402705A5074137472 @default.
- W2010402705 hasAuthorship W2010402705A5087457611 @default.
- W2010402705 hasBestOaLocation W20104027051 @default.
- W2010402705 hasConcept C101544691 @default.
- W2010402705 hasConcept C102268210 @default.
- W2010402705 hasConcept C104317684 @default.
- W2010402705 hasConcept C134459356 @default.
- W2010402705 hasConcept C1491633281 @default.
- W2010402705 hasConcept C170493617 @default.
- W2010402705 hasConcept C25602115 @default.
- W2010402705 hasConcept C28005876 @default.
- W2010402705 hasConcept C2911166042 @default.
- W2010402705 hasConcept C54355233 @default.
- W2010402705 hasConcept C62478195 @default.
- W2010402705 hasConcept C86803240 @default.
- W2010402705 hasConcept C95444343 @default.
- W2010402705 hasConceptScore W2010402705C101544691 @default.
- W2010402705 hasConceptScore W2010402705C102268210 @default.
- W2010402705 hasConceptScore W2010402705C104317684 @default.