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- W2010407495 abstract "We have adapted a RIA to the measurement of 17α-hydroxyprogesterone [17α-hydroxypregn-4-ene-3,20-dione (17-OHP)] in urine and have evaluated it as a tool in diagnosis and management of congenital adrenal hyperplasia (CAH). In 51 normal subjects, aged 3 days to 57 yr, the mean excretion of 17-OHP was 200 ng/day, with a range of 21–799 ng/day. As a ratio of 17-OHP to creatinine excreted in 7 normal infants, aged 3 days to 1 month, the mean was 4.13 ng/mg creatinine, with a range of 0.77–9.70 ng/mg creatinine; the mean for the remaining 44 subjects, aged 2–57 yr, was 0.21 ng/mg creatinine, with a range of 0.04–0.47 ng/mg creatinine. In urine samples from 13 children hospitalized with nonadrenal illnesses, the 17-OHP excretions, either as total per 24 h or as the ratio of 17-OHP to creatinine excreted, were similar to values seen in normal children of comparable age. In 6 new cases of CAH diagnosed in infancy, the urine 17-OHP ranged from 544–4370 ng/day (18.0–140 ng 17-OHP/mg creatinine), whereas the urine pregnanetriol (5β-pregnane-3α,17α,20α-triol) in 1 of the neonates was unmeasurable and in 2 others was only equivocally elevated. There was good correlation (r = 0.853) between 17-OHP and pregnanetriol in 24-h urine collections obtained from 34 patients during therapy of CAH. As a biochemical parameter in monitoring therapy of CAH, 17-OHP in urine may prove superior to pregnanetriol, particularly in neonates who may not excrete elevated levels of pregnanetriol." @default.
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- W2010407495 date "1979-09-01" @default.
- W2010407495 modified "2023-09-26" @default.
- W2010407495 title "Urinary 17α-Hydroxyprogesterone in Diagnosis and Management of Congenital Adrenal Hyperplasia" @default.
- W2010407495 doi "https://doi.org/10.1210/jcem-49-3-377" @default.
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