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• W2010408026 abstract "The first asymmetric total synthesis of EI-1941−1, −2, and −3, inhibitors of the interleukin-1β converting enzyme (ICE), has been accomplished, starting from a chiral epoxy iodoquinone 11, a key intermediate in our total synthesis of epoxyquinols A and B. Despite a failure to synthesize the inhibitors by our postulated biosynthetic route, we were able to diastereoselectively synthesize them via an intramolecular carboxypalladation with the key steps being a 6-endo cyclization mode followed by β-hydride elimination. The investigation of the biological properties of EI-1941−1, −2, and −3 and their derivatives disclosed them to be potent and effective ICE inhibitors with less cytotoxicity than EI-1941−1 and −2 in a cultured cell system." @default.
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• W2010408026 date "2005-11-01" @default.
• W2010408026 modified "2023-10-16" @default.
• W2010408026 title "Enantio- and Diastereoselective Total Synthesis of EI-1941−1, −2, and −3, Inhibitors of Interleukin-1β Converting Enzyme, and Biological Properties of Their Derivatives" @default.
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• W2010408026 doi "https://doi.org/10.1021/jo0516436" @default.
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