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• W2010408042 abstract "<h2>Abstract</h2><h3>Background</h3> HCV infection is frequently associated with liver steatosis. <h3>Aims and methods</h3> We studied 126 frozen liver HCV positive specimens (genotype-3=27) without any features of metabolic syndrome, searching for a correlation between the number of HCV infected hepatocytes and the presence, amount and distribution of steatosis in relation to different genotypes. <h3>Results</h3> Mean steatosis score was higher in genotype-3 with respect to non-3 (1.11 vs 0.66, <i>p</i>=0.022). HCV-antigens were detected by an immunoperoxidase technique in 91/126 (72.2%) cases. A significant correlation between the number of HCV-antigen positive cells and the degree of liver steatosis was observed in genotype-3 (<i>p</i>=0.01) but not in non-3 patients, matched for sex and age. Steatotic cells usually outnumbered HCV-infected cells. Steatosis was observed both in HCV-antigen positive and negative hepatocytes, and HCV-antigens were detected in both hepatocytes with and without steatosis: while no lobular codistribution was found in genotype non-3, in genotype-3 steatosis and HCV-antigens were usually found in the same areas. <h3>Conclusion</h3> Our data support the role of HCV-antigen liver expression in the pathogenesis of steatosis in genotype-3, however, since the presence of HCV-antigens is not directly related to steatosis within single hepatocytes, an indirect mechanism might be operative too." @default.
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• W2010408042 date "2009-09-01" @default.
• W2010408042 modified "2023-09-24" @default.
• W2010408042 title "Liver HCV-antigens and steatosis in chronic hepatitis C: Role of different genotypes" @default.
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• W2010408042 doi "https://doi.org/10.1016/j.dld.2008.12.093" @default.
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