FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010410406> ?p ?o ?g. }

• W2010410406 endingPage "900" @default.
• W2010410406 startingPage "891" @default.
• W2010410406 abstract "In 1967 Tranzer and Thoenen (1,2) recognized that 6-hydroxydopamine has the capacity for selectively destroying adrenergic nerve terminals. Two hydroxyserotonin isomers have a similar effect on the serotonin-containing neurons (3,4,5,6). Since the discoveries of these phenomena, 6-hydroxydopamine and 5,6 and 5,7-dihydroxytryptamine have become valuable pharmacological tools in the selective degeneration of noradrenergic and respectively serotonergic nerve terminals. In low doses, 6-hydroxydopamine is taken up into adrenergic nerve terminals without producing any detectable damage, acting as a false neurotransmitter. The administration of large doses of 6-hydroxydopamine results in very long-lasting sympathomimetic effects which are accompanied by a gradual deterioration of various specific functions of the neuronal membrane of the adrenergic nerve terminal (7,8,9). Repeated administration of high doses of 6-hydroxydopamine leads to an extensive destruction of adrenergic nerve terminals in all species studied so far (10). In general, the cell bodies of adrenergic neurons seem to be very resistant to the destructive effect of 6-hydroxydopamine compared to the nerve terminals. The two dihydroxylated indoleamines, 5,6-dihydroxytryptamine and 5,7-dihydroxytryptamine, produce long-lasting depletions in brain serotonin (3,11,12). Biochemical and morphological evidence suggests that these severe reductions of serotonin level are the result of degeneration of the axons and terminals of central serotonin containing neurons (13,14,15). These neurocytotoxic agents exhibit many pharmacological and biochemical properties which are beyond the scope of this short review which aims to cover only the various approaches reported in the literature dealing with the mechanism of action of above compounds." @default.
• W2010410406 created "2016-06-24" @default.
• W2010410406 creator A5024784208 @default.
• W2010410406 date "1977-10-01" @default.
• W2010410406 modified "2023-09-25" @default.
• W2010410406 title "The mechanism of action of neurocytotoxic compounds" @default.
• W2010410406 cites W1480914201 @default.
• W2010410406 cites W1488326150 @default.
• W2010410406 cites W1964517676 @default.
• W2010410406 cites W1971687151 @default.
• W2010410406 cites W1979379383 @default.
• W2010410406 cites W1980041025 @default.
• W2010410406 cites W1981321511 @default.
• W2010410406 cites W1988577667 @default.
• W2010410406 cites W2000895435 @default.
• W2010410406 cites W2002287054 @default.
• W2010410406 cites W2012920259 @default.
• W2010410406 cites W2014375114 @default.
• W2010410406 cites W2017348709 @default.
• W2010410406 cites W2039042531 @default.
• W2010410406 cites W2039049729 @default.
• W2010410406 cites W2042038355 @default.
• W2010410406 cites W2043653688 @default.
• W2010410406 cites W2045530227 @default.
• W2010410406 cites W2048838076 @default.
• W2010410406 cites W2049471279 @default.
• W2010410406 cites W2053353386 @default.
• W2010410406 cites W2061392844 @default.
• W2010410406 cites W2065045492 @default.
• W2010410406 cites W2068852450 @default.
• W2010410406 cites W2069481392 @default.
• W2010410406 cites W2071577749 @default.
• W2010410406 cites W2076068606 @default.
• W2010410406 cites W2081253940 @default.
• W2010410406 cites W2084628332 @default.
• W2010410406 cites W2086483799 @default.
• W2010410406 cites W2088217946 @default.
• W2010410406 cites W2091236497 @default.
• W2010410406 cites W2091316313 @default.
• W2010410406 cites W2094516654 @default.
• W2010410406 cites W2101459312 @default.
• W2010410406 cites W2117966002 @default.
• W2010410406 cites W2135112754 @default.
• W2010410406 cites W2160824435 @default.
• W2010410406 doi "https://doi.org/10.1016/0024-3205(77)90252-1" @default.
• W2010410406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/927019" @default.
• W2010410406 hasPublicationYear "1977" @default.
• W2010410406 type Work @default.
• W2010410406 sameAs 2010410406 @default.
• W2010410406 citedByCount "21" @default.
• W2010410406 crossrefType "journal-article" @default.
• W2010410406 hasAuthorship W2010410406A5024784208 @default.
• W2010410406 hasConcept C126322002 @default.
• W2010410406 hasConcept C134018914 @default.
• W2010410406 hasConcept C136357698 @default.
• W2010410406 hasConcept C137183658 @default.
• W2010410406 hasConcept C158453852 @default.
• W2010410406 hasConcept C169760540 @default.
• W2010410406 hasConcept C170493617 @default.
• W2010410406 hasConcept C185592680 @default.
• W2010410406 hasConcept C2775864247 @default.
• W2010410406 hasConcept C2776219046 @default.
• W2010410406 hasConcept C2910300410 @default.
• W2010410406 hasConcept C2911016594 @default.
• W2010410406 hasConcept C37000724 @default.
• W2010410406 hasConcept C513476851 @default.
• W2010410406 hasConcept C529278444 @default.
• W2010410406 hasConcept C71924100 @default.
• W2010410406 hasConcept C86803240 @default.
• W2010410406 hasConcept C98274493 @default.
• W2010410406 hasConceptScore W2010410406C126322002 @default.
• W2010410406 hasConceptScore W2010410406C134018914 @default.
• W2010410406 hasConceptScore W2010410406C136357698 @default.
• W2010410406 hasConceptScore W2010410406C137183658 @default.
• W2010410406 hasConceptScore W2010410406C158453852 @default.
• W2010410406 hasConceptScore W2010410406C169760540 @default.
• W2010410406 hasConceptScore W2010410406C170493617 @default.
• W2010410406 hasConceptScore W2010410406C185592680 @default.
• W2010410406 hasConceptScore W2010410406C2775864247 @default.
• W2010410406 hasConceptScore W2010410406C2776219046 @default.
• W2010410406 hasConceptScore W2010410406C2910300410 @default.
• W2010410406 hasConceptScore W2010410406C2911016594 @default.
• W2010410406 hasConceptScore W2010410406C37000724 @default.
• W2010410406 hasConceptScore W2010410406C513476851 @default.
• W2010410406 hasConceptScore W2010410406C529278444 @default.
• W2010410406 hasConceptScore W2010410406C71924100 @default.
• W2010410406 hasConceptScore W2010410406C86803240 @default.
• W2010410406 hasConceptScore W2010410406C98274493 @default.
• W2010410406 hasIssue "7" @default.
• W2010410406 hasLocation W20104104061 @default.
• W2010410406 hasLocation W20104104062 @default.
• W2010410406 hasOpenAccess W2010410406 @default.
• W2010410406 hasPrimaryLocation W20104104061 @default.
• W2010410406 hasRelatedWork W1984841954 @default.
• W2010410406 hasRelatedWork W2000862968 @default.
• W2010410406 hasRelatedWork W2010410406 @default.
• W2010410406 hasRelatedWork W2050824222 @default.
• W2010410406 hasRelatedWork W2059229723 @default.

• next