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• W2010410884 abstract "Abstract Matrix metalloproteinase‐9 (MMP‐9) and NADPH oxidase contribute to blood–brain barrier (BBB) disruption after ischemic stroke. We have previously shown that normobaric hyperoxia (NBO) treatment reduces MMP‐9 and oxygen free radical generation in ischemic brain. In this study, we tested the hypothesis that NBO protects the BBB through inhibiting NADPH oxidase‐mediated MMP‐9 induction in transient focal cerebral ischemia. Male Sprague–Dawley rats ( n = 69) were given NBO (95% O 2 ) or normoxia (21% O 2 ) during 90‐min filament occlusion of the middle cerebral artery. Cerebral microvessels were isolated for analyzing MMP‐9 and NADPH oxidase. BBB damage was non‐invasively quantified with magnetic resonance imaging. In normoxic rats, both NADPH oxidase catalytic subunit gp91 phox and MMP‐9 expression were up‐regulated in ischemic hemispheric microvessels after 90‐min middle cerebral artery occlusion with 22.5 h reperfusion. Inhibition of NADPH oxidase with apocynin reduced the MMP‐9 increase, indicating a causal link between NADPH oxidase‐derived superoxide and MMP‐9 induction. NBO treatment inhibited gp91 phox expression, NADPH oxidase activity, and MMP‐9 induction, which led to significantly less BBB damage and brain edema in the ischemic brain. These results suggest that gp91 phox containing NADPH oxidase plays an important role in MMP‐9 induction in ischemic BBB microvasculature, and that NBO treatment may attenuate MMP‐9 induction and brain edema through inhibiting NADPH oxidase after transient cerebral ischemia." @default.
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• W2010410884 date "2008-11-11" @default.
• W2010410884 modified "2023-10-17" @default.
• W2010410884 title "Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke" @default.
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• W2010410884 doi "https://doi.org/10.1111/j.1471-4159.2008.05664.x" @default.
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