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- W2010412611 abstract "Beta-lactamases are a superfamily of enzymes which degrade the β -lactam class of antibiotics. They are produced endogenously by the bacterial cells, which when exposed to the β -lactam class of antibiotics inactivate them by cleaving the β -lactam ring. Based on the presence or absence of metallic ligand, β -lactamases have been divided into two broad functional classes. β -Lactamases are a constitutively evolving and expanding superfamily of enzymes, which could be further subdivided on the basis of presence/absence of conserved motifs. In the present study we have used the MEME/MAST suit to identify the patterns/motifs which are specific to a particular family or subfamily of β -lactamases. The family specific patterns/motifs can be also useful in recognizing and assigning newly discovered β -lactamases to one or the other family or subfamily. Cross-validation showed that the proposed method is highly sensitive and specific. We have also designed a webserver, LactFP, for this purpose." @default.
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- W2010412611 date "2014-01-01" @default.
- W2010412611 modified "2023-09-25" @default.
- W2010412611 title "Identification of Family Specific Fingerprints in<b><i>β</i></b>-Lactamase Families" @default.
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- W2010412611 doi "https://doi.org/10.1155/2014/980572" @default.
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