FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010413312> ?p ?o ?g. }

• W2010413312 endingPage "2375" @default.
• W2010413312 startingPage "2370" @default.
• W2010413312 abstract "The protein Vezf1 plays multiple roles important for embryonic development. In Vezf1 −/− mouse embryonic stem (mES) cells, our earlier data showed widespread changes in gene-expression profiles, including decreased expression of the full-length active isoform of Dnmt3b methyltransferase and concomitant genome-wide reduction in DNA methylation. Here we show that in HeLaS3 cells there is a strong genome-wide correlation between Vezf1 binding and peaks of elongating Ser2-P RNA polymerase (Pol) ll, reflecting Vezf1-dependent slowing of elongation. In WT mES cells, the elongating form of RNA pol II accumulates near Vezf1 binding sites within the dnmt3b gene and at several other Vezf1 sites, and this accumulation is significantly reduced at these sites in Vezf1 −/− mES cells. Depending upon genomic location, Vezf1-mediated Pol II pausing can have different regulatory roles in transcription and splicing. We find examples of genes in which Vezf1 binding sites are located near cassette exons, and in which loss of Vezf1 leads to a change in the relative abundance of alternatively spliced messages. We further show that Vezf1 interacts with Mrg15/Mrgbp, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites." @default.
• W2010413312 created "2016-06-24" @default.
• W2010413312 creator A5008061394 @default.
• W2010413312 creator A5012187026 @default.
• W2010413312 creator A5020110134 @default.
• W2010413312 creator A5037088178 @default.
• W2010413312 date "2012-01-30" @default.
• W2010413312 modified "2023-09-23" @default.
• W2010413312 title "Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II" @default.
• W2010413312 cites W1879167427 @default.
• W2010413312 cites W1900197145 @default.
• W2010413312 cites W1965582387 @default.
• W2010413312 cites W1971434447 @default.
• W2010413312 cites W1972962841 @default.
• W2010413312 cites W1973697733 @default.
• W2010413312 cites W1974434328 @default.
• W2010413312 cites W1976365653 @default.
• W2010413312 cites W1989753076 @default.
• W2010413312 cites W1993749620 @default.
• W2010413312 cites W1996813139 @default.
• W2010413312 cites W2007844697 @default.
• W2010413312 cites W2009111836 @default.
• W2010413312 cites W2012699815 @default.
• W2010413312 cites W2019937806 @default.
• W2010413312 cites W2021309463 @default.
• W2010413312 cites W2031197577 @default.
• W2010413312 cites W2032446389 @default.
• W2010413312 cites W2040481343 @default.
• W2010413312 cites W2054980646 @default.
• W2010413312 cites W2063800517 @default.
• W2010413312 cites W2069328568 @default.
• W2010413312 cites W2081099987 @default.
• W2010413312 cites W2089422977 @default.
• W2010413312 cites W2089789185 @default.
• W2010413312 cites W2091069693 @default.
• W2010413312 cites W2096461858 @default.
• W2010413312 cites W2099564858 @default.
• W2010413312 cites W2110776599 @default.
• W2010413312 cites W2116971159 @default.
• W2010413312 cites W2129963496 @default.
• W2010413312 cites W2132201134 @default.
• W2010413312 cites W2135229538 @default.
• W2010413312 cites W2153849837 @default.
• W2010413312 cites W2160655220 @default.
• W2010413312 cites W2163358451 @default.
• W2010413312 cites W2165673663 @default.
• W2010413312 cites W2830354 @default.
• W2010413312 doi "https://doi.org/10.1073/pnas.1121538109" @default.
• W2010413312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3289347" @default.
• W2010413312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22308494" @default.
• W2010413312 hasPublicationYear "2012" @default.
• W2010413312 type Work @default.
• W2010413312 sameAs 2010413312 @default.
• W2010413312 citedByCount "34" @default.
• W2010413312 countsByYear W20104133122012 @default.
• W2010413312 countsByYear W20104133122013 @default.
• W2010413312 countsByYear W20104133122014 @default.
• W2010413312 countsByYear W20104133122015 @default.
• W2010413312 countsByYear W20104133122016 @default.
• W2010413312 countsByYear W20104133122017 @default.
• W2010413312 countsByYear W20104133122018 @default.
• W2010413312 countsByYear W20104133122019 @default.
• W2010413312 countsByYear W20104133122020 @default.
• W2010413312 countsByYear W20104133122021 @default.
• W2010413312 countsByYear W20104133122022 @default.
• W2010413312 countsByYear W20104133122023 @default.
• W2010413312 crossrefType "journal-article" @default.
• W2010413312 hasAuthorship W2010413312A5008061394 @default.
• W2010413312 hasAuthorship W2010413312A5012187026 @default.
• W2010413312 hasAuthorship W2010413312A5020110134 @default.
• W2010413312 hasAuthorship W2010413312A5037088178 @default.
• W2010413312 hasBestOaLocation W20104133121 @default.
• W2010413312 hasConcept C101762097 @default.
• W2010413312 hasConcept C104317684 @default.
• W2010413312 hasConcept C150194340 @default.
• W2010413312 hasConcept C153911025 @default.
• W2010413312 hasConcept C194583182 @default.
• W2010413312 hasConcept C2776449523 @default.
• W2010413312 hasConcept C36823959 @default.
• W2010413312 hasConcept C54355233 @default.
• W2010413312 hasConcept C54458228 @default.
• W2010413312 hasConcept C64350747 @default.
• W2010413312 hasConcept C67705224 @default.
• W2010413312 hasConcept C70916841 @default.
• W2010413312 hasConcept C86803240 @default.
• W2010413312 hasConcept C95444343 @default.
• W2010413312 hasConceptScore W2010413312C101762097 @default.
• W2010413312 hasConceptScore W2010413312C104317684 @default.
• W2010413312 hasConceptScore W2010413312C150194340 @default.
• W2010413312 hasConceptScore W2010413312C153911025 @default.
• W2010413312 hasConceptScore W2010413312C194583182 @default.
• W2010413312 hasConceptScore W2010413312C2776449523 @default.
• W2010413312 hasConceptScore W2010413312C36823959 @default.
• W2010413312 hasConceptScore W2010413312C54355233 @default.
• W2010413312 hasConceptScore W2010413312C54458228 @default.
• W2010413312 hasConceptScore W2010413312C64350747 @default.
• W2010413312 hasConceptScore W2010413312C67705224 @default.
• W2010413312 hasConceptScore W2010413312C70916841 @default.

• next