Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010415056> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2010415056 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILChemopreventive compound SR13668 showed promising anti-cancer activity in several in vitro and in vivo models of cancer, including breast, lung, prostate, and ovary and it was proposed that SR13668 works through the modulation of PI3K/Akt pathway. However, low oral bioavailability substantially limited its development as a chemopreventive agent. A novel nano-formulation of SR13668 encapsulated in poly(lactic-co-glycolic acid) (PLGA) was produced with the aim to enhance the oral bioavailability of SR13668 in beagle dogs. A single gavage administration of SR13668 was performed at 2.8 mg/kg as nano-formulation and also as SR13668 in 0.5 % methylcellulose in 4 male and 4 female dogs. Whole blood and plasma samples withdrawn from these animals at different time points over 24 hr period were analyzed using LC-MS/MS method to obtain the systemic drug levels and to evaluate the pharmacokinetic profile achieved. In plasma the group mean highest concentration occurred at the 4 hr time point in both males (29.6 ng/mL) and females (27.9 ng/mL) whereas in whole blood the mean group peak occurred at 4 hr in males (51.7 ng/mL) and 6 hr in females (61.9 ng/mL). The animals dosed with SR13668 in methylcellulose had all levels below limit of quantitation (1.1 ng/mL) in both plasma and whole blood for all time points. This study was the first attempt of using nano-formulation to improve oral bioavailability of the chemopreventive compound SR13668 in large animals. The systemic levels achieved were high for this poorly bioavailable compound in dogs but were not to the desired levels and further work is needed to improve bioavailability using nano-formulations. Potential improvements that are planned for the SR13668 nano-formulations include using a high through-put screening method to optimize the conditions further, use of polyethyleneglycol- poly(lactic-co-glycolic acid) (PEG-PLGA) for SR13668 encapsulation and comparison with poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEG-b-PCL) and PLGA results to possibly obtain better absorption with increased stability in the gut and also placement of negative charges on the nano-particles using poly-acrylic acid (PAA) to facilitate the particle penetrating the mucus layer to increase bioavailability.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2902. doi:1538-7445.AM2012-2902" @default.
- W2010415056 created "2016-06-24" @default.
- W2010415056 creator A5016615064 @default.
- W2010415056 creator A5044766782 @default.
- W2010415056 creator A5047034211 @default.
- W2010415056 creator A5060002817 @default.
- W2010415056 creator A5075577034 @default.
- W2010415056 creator A5081868329 @default.
- W2010415056 creator A5089049525 @default.
- W2010415056 date "2012-04-15" @default.
- W2010415056 modified "2023-09-27" @default.
- W2010415056 title "Abstract 2902: Polymeric nanoparticles enhance the bioavailability of the chemopreventive compound SR13668 in beagle dogs" @default.
- W2010415056 doi "https://doi.org/10.1158/1538-7445.am2012-2902" @default.
- W2010415056 hasPublicationYear "2012" @default.
- W2010415056 type Work @default.
- W2010415056 sameAs 2010415056 @default.
- W2010415056 citedByCount "0" @default.
- W2010415056 crossrefType "proceedings-article" @default.
- W2010415056 hasAuthorship W2010415056A5016615064 @default.
- W2010415056 hasAuthorship W2010415056A5044766782 @default.
- W2010415056 hasAuthorship W2010415056A5047034211 @default.
- W2010415056 hasAuthorship W2010415056A5060002817 @default.
- W2010415056 hasAuthorship W2010415056A5075577034 @default.
- W2010415056 hasAuthorship W2010415056A5081868329 @default.
- W2010415056 hasAuthorship W2010415056A5089049525 @default.
- W2010415056 hasConcept C112705442 @default.
- W2010415056 hasConcept C121608353 @default.
- W2010415056 hasConcept C126322002 @default.
- W2010415056 hasConcept C150903083 @default.
- W2010415056 hasConcept C1621761 @default.
- W2010415056 hasConcept C181389837 @default.
- W2010415056 hasConcept C185592680 @default.
- W2010415056 hasConcept C207001950 @default.
- W2010415056 hasConcept C2776820430 @default.
- W2010415056 hasConcept C2777056448 @default.
- W2010415056 hasConcept C71924100 @default.
- W2010415056 hasConcept C86803240 @default.
- W2010415056 hasConcept C98274493 @default.
- W2010415056 hasConceptScore W2010415056C112705442 @default.
- W2010415056 hasConceptScore W2010415056C121608353 @default.
- W2010415056 hasConceptScore W2010415056C126322002 @default.
- W2010415056 hasConceptScore W2010415056C150903083 @default.
- W2010415056 hasConceptScore W2010415056C1621761 @default.
- W2010415056 hasConceptScore W2010415056C181389837 @default.
- W2010415056 hasConceptScore W2010415056C185592680 @default.
- W2010415056 hasConceptScore W2010415056C207001950 @default.
- W2010415056 hasConceptScore W2010415056C2776820430 @default.
- W2010415056 hasConceptScore W2010415056C2777056448 @default.
- W2010415056 hasConceptScore W2010415056C71924100 @default.
- W2010415056 hasConceptScore W2010415056C86803240 @default.
- W2010415056 hasConceptScore W2010415056C98274493 @default.
- W2010415056 hasLocation W20104150561 @default.
- W2010415056 hasOpenAccess W2010415056 @default.
- W2010415056 hasPrimaryLocation W20104150561 @default.
- W2010415056 hasRelatedWork W1965944527 @default.
- W2010415056 hasRelatedWork W1968037630 @default.
- W2010415056 hasRelatedWork W1979502971 @default.
- W2010415056 hasRelatedWork W2012104713 @default.
- W2010415056 hasRelatedWork W2016501570 @default.
- W2010415056 hasRelatedWork W2035969622 @default.
- W2010415056 hasRelatedWork W2041885280 @default.
- W2010415056 hasRelatedWork W2052004769 @default.
- W2010415056 hasRelatedWork W2052675271 @default.
- W2010415056 hasRelatedWork W2058465983 @default.
- W2010415056 hasRelatedWork W2061941808 @default.
- W2010415056 hasRelatedWork W2347742629 @default.
- W2010415056 hasRelatedWork W2495603527 @default.
- W2010415056 hasRelatedWork W2552418679 @default.
- W2010415056 hasRelatedWork W2554695056 @default.
- W2010415056 hasRelatedWork W2773182299 @default.
- W2010415056 hasRelatedWork W2795466243 @default.
- W2010415056 hasRelatedWork W2802760424 @default.
- W2010415056 hasRelatedWork W2950919987 @default.
- W2010415056 hasRelatedWork W3024727384 @default.
- W2010415056 isParatext "false" @default.
- W2010415056 isRetracted "false" @default.
- W2010415056 magId "2010415056" @default.
- W2010415056 workType "article" @default.