Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010416043> ?p ?o ?g. }
- W2010416043 endingPage "157" @default.
- W2010416043 startingPage "141" @default.
- W2010416043 abstract "Replication-deficient viral vectors encoding the marker gene green fluorescent protein (GFP) were injected into the vitreous of newborn, juvenile (P14), and adult rats. We tested two different types of modified virus: adeno-associated viral-2-GFP (AAV-GFP) and lentiviral-GFP vectors (LV-GFP). The extent of retinal cell transduction in different-aged animals was compared 7, 21, and 70 days after eye injections. At all postinjection times, LV-GFP transduction was mostly limited to pigment epithelium and cells in sclera and choroid. In contrast, transduction of large numbers of neural retinal cells was seen 21 and 70 days after AAV-GFP injections. AAV-GFP predominantly transduced neurons, although GFP-positive Müller cells were seen. All neuronal classes were labeled, but the extent of transduction for a given class varied depending on injection age. After P0 injections about 50% of transduced cells were photoreceptors and 30-40% were amacrine or bipolar cells. After adult injections 60-70% of transduced cells were retinal ganglion cells. In adults many GFP-positive retinal axons were traced through the optic nerve/tract and terminal arbors were visualized in central targets." @default.
- W2010416043 created "2016-06-24" @default.
- W2010416043 creator A5007608164 @default.
- W2010416043 creator A5018414595 @default.
- W2010416043 creator A5025381974 @default.
- W2010416043 creator A5047000391 @default.
- W2010416043 creator A5064750157 @default.
- W2010416043 creator A5070387545 @default.
- W2010416043 creator A5071595223 @default.
- W2010416043 creator A5090136803 @default.
- W2010416043 date "2002-09-01" @default.
- W2010416043 modified "2023-09-25" @default.
- W2010416043 title "Intravitreal Injection of Adeno-associated Viral Vectors Results in the Transduction of Different Types of Retinal Neurons in Neonatal and Adult Rats: A Comparison with Lentiviral Vectors" @default.
- W2010416043 cites W116247966 @default.
- W2010416043 cites W1505196125 @default.
- W2010416043 cites W1598111769 @default.
- W2010416043 cites W1608422293 @default.
- W2010416043 cites W1756236371 @default.
- W2010416043 cites W1894275975 @default.
- W2010416043 cites W1968924490 @default.
- W2010416043 cites W1972583115 @default.
- W2010416043 cites W1972747973 @default.
- W2010416043 cites W1973203787 @default.
- W2010416043 cites W1973389197 @default.
- W2010416043 cites W1981449360 @default.
- W2010416043 cites W1988463041 @default.
- W2010416043 cites W1989386072 @default.
- W2010416043 cites W1991157268 @default.
- W2010416043 cites W1994396884 @default.
- W2010416043 cites W2000341011 @default.
- W2010416043 cites W2002289731 @default.
- W2010416043 cites W2007129820 @default.
- W2010416043 cites W2007245313 @default.
- W2010416043 cites W2008512248 @default.
- W2010416043 cites W2015282830 @default.
- W2010416043 cites W2016390889 @default.
- W2010416043 cites W2018423388 @default.
- W2010416043 cites W2019284896 @default.
- W2010416043 cites W2024840529 @default.
- W2010416043 cites W2028291183 @default.
- W2010416043 cites W2032196019 @default.
- W2010416043 cites W2033915545 @default.
- W2010416043 cites W2038036971 @default.
- W2010416043 cites W2043375698 @default.
- W2010416043 cites W2047633827 @default.
- W2010416043 cites W2049420308 @default.
- W2010416043 cites W2050041384 @default.
- W2010416043 cites W2052619273 @default.
- W2010416043 cites W2054490530 @default.
- W2010416043 cites W2060437644 @default.
- W2010416043 cites W2061055842 @default.
- W2010416043 cites W2064199560 @default.
- W2010416043 cites W2065052232 @default.
- W2010416043 cites W2068069084 @default.
- W2010416043 cites W2069090038 @default.
- W2010416043 cites W2073539399 @default.
- W2010416043 cites W2073922747 @default.
- W2010416043 cites W2095609662 @default.
- W2010416043 cites W2096454490 @default.
- W2010416043 cites W2099690691 @default.
- W2010416043 cites W2105482019 @default.
- W2010416043 cites W2116596989 @default.
- W2010416043 cites W2124026319 @default.
- W2010416043 cites W2124077248 @default.
- W2010416043 cites W2126487187 @default.
- W2010416043 cites W2128298711 @default.
- W2010416043 cites W2131788411 @default.
- W2010416043 cites W2134729533 @default.
- W2010416043 cites W2141354154 @default.
- W2010416043 cites W2142334980 @default.
- W2010416043 cites W2153283555 @default.
- W2010416043 cites W2158647587 @default.
- W2010416043 cites W2160765822 @default.
- W2010416043 cites W2175546026 @default.
- W2010416043 cites W2176119731 @default.
- W2010416043 cites W2413552259 @default.
- W2010416043 cites W2423484061 @default.
- W2010416043 cites W4206826545 @default.
- W2010416043 cites W4312861573 @default.
- W2010416043 doi "https://doi.org/10.1006/mcne.2002.1168" @default.
- W2010416043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12359157" @default.
- W2010416043 hasPublicationYear "2002" @default.
- W2010416043 type Work @default.
- W2010416043 sameAs 2010416043 @default.
- W2010416043 citedByCount "102" @default.
- W2010416043 countsByYear W20104160432012 @default.
- W2010416043 countsByYear W20104160432013 @default.
- W2010416043 countsByYear W20104160432014 @default.
- W2010416043 countsByYear W20104160432015 @default.
- W2010416043 countsByYear W20104160432016 @default.
- W2010416043 countsByYear W20104160432017 @default.
- W2010416043 countsByYear W20104160432018 @default.
- W2010416043 countsByYear W20104160432019 @default.
- W2010416043 countsByYear W20104160432020 @default.
- W2010416043 countsByYear W20104160432021 @default.
- W2010416043 countsByYear W20104160432022 @default.
- W2010416043 countsByYear W20104160432023 @default.
- W2010416043 crossrefType "journal-article" @default.