FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010419404> ?p ?o ?g. }

• W2010419404 endingPage "1998" @default.
• W2010419404 startingPage "1993" @default.
• W2010419404 abstract "A single-nucleotide polymorphism in the PTPN22 gene encoding the lymphoid protein tyrosine phosphatase (Lyp) has recently been identified as a functional variant associated with susceptibility to rheumatoid arthritis (RA), type 1 diabetes, and systemic lupus erythematosus. To determine whether association of this variant (PTPN22 1858T) with RA is reproducible and is also observed in another autoimmune condition, Crohn's disease, we investigated the association between the PTPN22 1858T allele and RA and Crohn's disease in a Canadian population.Two RA case-control cohorts representing a total of 1,234 patients and 791 healthy controls as well as a cohort of 455 patients with Crohn's disease and 190 controls were genotyped for the PTPN22 C1858T polymorphism, and genotype frequencies were compared between patients and controls.Significant association of the PTPN22 1858T allele with RA was detected in both the Toronto-based RA cohort (P = 1.6 x 10(-6), odds ratio [OR] 1.8) and the Halifax-based RA cohort (P = 9.4 x 10(-4), OR 1.94). Association of the risk allele with RA was not affected by sex, age at disease onset, or the presence of either rheumatoid factor or rheumatoid nodules. No association between the PTPN22 risk allele and Crohn's disease was detected.These observations confirm the association of RA susceptibility with the PTPN22 1858T allele. However, the data also reveal a lack of association between this variant and Crohn's disease, suggesting that the PTPN22 1858T allele is a risk allele for multiple, but not all, autoimmune diseases." @default.
• W2010419404 created "2016-06-24" @default.
• W2010419404 creator A5006025669 @default.
• W2010419404 creator A5007934008 @default.
• W2010419404 creator A5008427456 @default.
• W2010419404 creator A5009020171 @default.
• W2010419404 creator A5028989565 @default.
• W2010419404 creator A5029321261 @default.
• W2010419404 creator A5040555937 @default.
• W2010419404 creator A5049032026 @default.
• W2010419404 creator A5060010227 @default.
• W2010419404 creator A5062765426 @default.
• W2010419404 creator A5069979151 @default.
• W2010419404 creator A5072764332 @default.
• W2010419404 creator A5074121579 @default.
• W2010419404 creator A5074196199 @default.
• W2010419404 creator A5085888398 @default.
• W2010419404 creator A5089194215 @default.
• W2010419404 date "2005-01-01" @default.
• W2010419404 modified "2023-10-02" @default.
• W2010419404 title "Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations" @default.
• W2010419404 cites W163644054 @default.
• W2010419404 cites W1642457845 @default.
• W2010419404 cites W1964395789 @default.
• W2010419404 cites W1974666828 @default.
• W2010419404 cites W1979482663 @default.
• W2010419404 cites W1981874823 @default.
• W2010419404 cites W1987055888 @default.
• W2010419404 cites W1987677365 @default.
• W2010419404 cites W1990678679 @default.
• W2010419404 cites W1994402720 @default.
• W2010419404 cites W1996378263 @default.
• W2010419404 cites W2008649874 @default.
• W2010419404 cites W2030117347 @default.
• W2010419404 cites W2035236079 @default.
• W2010419404 cites W2035249926 @default.
• W2010419404 cites W2038100682 @default.
• W2010419404 cites W2046383867 @default.
• W2010419404 cites W2049326963 @default.
• W2010419404 cites W2076186450 @default.
• W2010419404 cites W2076646585 @default.
• W2010419404 cites W2082062343 @default.
• W2010419404 cites W2093120748 @default.
• W2010419404 cites W2096063169 @default.
• W2010419404 cites W2102079012 @default.
• W2010419404 cites W2106681973 @default.
• W2010419404 cites W2130309165 @default.
• W2010419404 cites W2137299974 @default.
• W2010419404 cites W2143249342 @default.
• W2010419404 cites W2145838429 @default.
• W2010419404 cites W2152348310 @default.
• W2010419404 cites W2165052240 @default.
• W2010419404 cites W317592431 @default.
• W2010419404 doi "https://doi.org/10.1002/art.21123" @default.
• W2010419404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15986374" @default.
• W2010419404 hasPublicationYear "2005" @default.
• W2010419404 type Work @default.
• W2010419404 sameAs 2010419404 @default.
• W2010419404 citedByCount "125" @default.
• W2010419404 countsByYear W20104194042012 @default.
• W2010419404 countsByYear W20104194042013 @default.
• W2010419404 countsByYear W20104194042014 @default.
• W2010419404 countsByYear W20104194042015 @default.
• W2010419404 countsByYear W20104194042016 @default.
• W2010419404 countsByYear W20104194042017 @default.
• W2010419404 countsByYear W20104194042018 @default.
• W2010419404 countsByYear W20104194042019 @default.
• W2010419404 countsByYear W20104194042020 @default.
• W2010419404 countsByYear W20104194042021 @default.
• W2010419404 countsByYear W20104194042022 @default.
• W2010419404 countsByYear W20104194042023 @default.
• W2010419404 crossrefType "journal-article" @default.
• W2010419404 hasAuthorship W2010419404A5006025669 @default.
• W2010419404 hasAuthorship W2010419404A5007934008 @default.
• W2010419404 hasAuthorship W2010419404A5008427456 @default.
• W2010419404 hasAuthorship W2010419404A5009020171 @default.
• W2010419404 hasAuthorship W2010419404A5028989565 @default.
• W2010419404 hasAuthorship W2010419404A5029321261 @default.
• W2010419404 hasAuthorship W2010419404A5040555937 @default.
• W2010419404 hasAuthorship W2010419404A5049032026 @default.
• W2010419404 hasAuthorship W2010419404A5060010227 @default.
• W2010419404 hasAuthorship W2010419404A5062765426 @default.
• W2010419404 hasAuthorship W2010419404A5069979151 @default.
• W2010419404 hasAuthorship W2010419404A5072764332 @default.
• W2010419404 hasAuthorship W2010419404A5074121579 @default.
• W2010419404 hasAuthorship W2010419404A5074196199 @default.
• W2010419404 hasAuthorship W2010419404A5085888398 @default.
• W2010419404 hasAuthorship W2010419404A5089194215 @default.
• W2010419404 hasConcept C104317684 @default.
• W2010419404 hasConcept C126322002 @default.
• W2010419404 hasConcept C135763542 @default.
• W2010419404 hasConcept C146304588 @default.
• W2010419404 hasConcept C153209595 @default.
• W2010419404 hasConcept C156957248 @default.
• W2010419404 hasConcept C180754005 @default.
• W2010419404 hasConcept C203014093 @default.
• W2010419404 hasConcept C2777575956 @default.
• W2010419404 hasConcept C2779356809 @default.

• next