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- W2010422175 abstract "As of yet, only a few strategies to prevent myocardial reperfusion injury have been tested clinically. In the first minutes of reperfusion, the myocardium can be damaged by contracture development, causing mechanical stiffness, tissue necrosis, and the stone heart phenomenon. Reperfusion-induced contracture can have two different causes, namely, Ca2+overload-induced contracture or rigor-type contracture. Ca2+ contracture results from rapid re-energization of contractile cells with a persistent Ca2+ overload. Strategies to prevent this type of injury are directed at cytosolic Ca2+ control or myofibrillar Ca2+ sensitivity. Rigor-contracture occurs when re-energization proceeds very slowly. It does not depend on Ca2+ overload. It may be prevented by strategies improving early mitochondrial reactivation" @default.
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- W2010422175 date "2003-02-01" @default.
- W2010422175 modified "2023-10-14" @default.
- W2010422175 title "Cellular mechanisms of ischemia-reperfusion injury" @default.
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- W2010422175 doi "https://doi.org/10.1016/s0003-4975(02)04686-6" @default.
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