FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010432185> ?p ?o ?g. }

• W2010432185 abstract "The only available contraceptive patch, Ortho Evra®, delivers a relatively high dose of estrogen.Three transdermal contraceptive delivery systems (TCDS) containing low doses of ethinylestradiol (EE) and levonorgestrel (LNG) were evaluated in two open-label randomized trials. In a phase 1, two-period, cross-over trial, AG200-12.5 and AG200LE were compared with a 150 μg LNG/30 μg EE oral contraceptive (OC) (Levlen®) in 39 women. In a phase 2, parallel-group, multicenter, three-cycle study, AG200LE, AG200-12.5 and a higher-dose formulation, AG200-15, were evaluated in 123 women.In Study 1, mean steady-state plasma concentrations (Css, pg/mL) for the TCDS were 17 pg/mL to 26 pg/mL for EE and 1117 pg/mL to 1505 pg/mL for LNG (for AG200LE and AG200-12.5 respectively). Maximum concentration (Cmax) and Css for both analytes were significantly lower than for Levlen. In both studies, the Css levels for EE and LNG in all groups were within the ranges reported for low-dose OCs. Cycle control for AG200-15, assessed by breakthrough bleeding and spotting episodes as well as number of days of unscheduled bleeding and/or spotting, was similar to that reported for low-dose OCs. Most adverse events were considered mild to moderate in intensity. The incidence of patches falling off was <2%.All three patches exhibited excellent safety and wearability profiles while maintaining plasma drug levels required for ovulation suppression and adequate cycle control. A slight increase in the EE dose in AG200-15 still places this TCDS within the range of low-dose OCs, with EE exposure much lower than reported for Ortho Evra. AG200-15 was selected for further testing in phase 3 studies." @default.
• W2010432185 created "2016-06-24" @default.
• W2010432185 creator A5004386740 @default.
• W2010432185 creator A5053540007 @default.
• W2010432185 creator A5065206401 @default.
• W2010432185 creator A5082592492 @default.
• W2010432185 date "2011-01-01" @default.
• W2010432185 modified "2023-09-26" @default.
• W2010432185 title "Pharmacokinetics, tolerability and cycle control of three transdermal contraceptive delivery systems containing different doses of ethinylestradiol and levonorgestrel" @default.
• W2010432185 cites W1964898875 @default.
• W2010432185 cites W1968296544 @default.
• W2010432185 cites W1979454140 @default.
• W2010432185 cites W1994163427 @default.
• W2010432185 cites W2011138842 @default.
• W2010432185 cites W2012586124 @default.
• W2010432185 cites W2017358385 @default.
• W2010432185 cites W2027530606 @default.
• W2010432185 cites W2031232537 @default.
• W2010432185 cites W2098904708 @default.
• W2010432185 cites W2098933196 @default.
• W2010432185 cites W2099018240 @default.
• W2010432185 cites W2103804399 @default.
• W2010432185 cites W2125085930 @default.
• W2010432185 cites W2140342815 @default.
• W2010432185 cites W2141839140 @default.
• W2010432185 cites W2148402834 @default.
• W2010432185 cites W2149668866 @default.
• W2010432185 doi "https://doi.org/10.1515/hmbci.2011.004" @default.
• W2010432185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25961260" @default.
• W2010432185 hasPublicationYear "2011" @default.
• W2010432185 type Work @default.
• W2010432185 sameAs 2010432185 @default.
• W2010432185 citedByCount "5" @default.
• W2010432185 countsByYear W20104321852012 @default.
• W2010432185 countsByYear W20104321852013 @default.
• W2010432185 countsByYear W20104321852015 @default.
• W2010432185 crossrefType "journal-article" @default.
• W2010432185 hasAuthorship W2010432185A5004386740 @default.
• W2010432185 hasAuthorship W2010432185A5053540007 @default.
• W2010432185 hasAuthorship W2010432185A5065206401 @default.
• W2010432185 hasAuthorship W2010432185A5082592492 @default.
• W2010432185 hasConcept C112705442 @default.
• W2010432185 hasConcept C126322002 @default.
• W2010432185 hasConcept C197934379 @default.
• W2010432185 hasConcept C205679159 @default.
• W2010432185 hasConcept C22979827 @default.
• W2010432185 hasConcept C2777702977 @default.
• W2010432185 hasConcept C2777902738 @default.
• W2010432185 hasConcept C2777956591 @default.
• W2010432185 hasConcept C2778375690 @default.
• W2010432185 hasConcept C2779076696 @default.
• W2010432185 hasConcept C2780186607 @default.
• W2010432185 hasConcept C2908647359 @default.
• W2010432185 hasConcept C2986817661 @default.
• W2010432185 hasConcept C71315377 @default.
• W2010432185 hasConcept C71924100 @default.
• W2010432185 hasConcept C98274493 @default.
• W2010432185 hasConcept C99454951 @default.
• W2010432185 hasConceptScore W2010432185C112705442 @default.
• W2010432185 hasConceptScore W2010432185C126322002 @default.
• W2010432185 hasConceptScore W2010432185C197934379 @default.
• W2010432185 hasConceptScore W2010432185C205679159 @default.
• W2010432185 hasConceptScore W2010432185C22979827 @default.
• W2010432185 hasConceptScore W2010432185C2777702977 @default.
• W2010432185 hasConceptScore W2010432185C2777902738 @default.
• W2010432185 hasConceptScore W2010432185C2777956591 @default.
• W2010432185 hasConceptScore W2010432185C2778375690 @default.
• W2010432185 hasConceptScore W2010432185C2779076696 @default.
• W2010432185 hasConceptScore W2010432185C2780186607 @default.
• W2010432185 hasConceptScore W2010432185C2908647359 @default.
• W2010432185 hasConceptScore W2010432185C2986817661 @default.
• W2010432185 hasConceptScore W2010432185C71315377 @default.
• W2010432185 hasConceptScore W2010432185C71924100 @default.
• W2010432185 hasConceptScore W2010432185C98274493 @default.
• W2010432185 hasConceptScore W2010432185C99454951 @default.
• W2010432185 hasLocation W20104321851 @default.
• W2010432185 hasLocation W20104321852 @default.
• W2010432185 hasOpenAccess W2010432185 @default.
• W2010432185 hasPrimaryLocation W20104321851 @default.
• W2010432185 hasRelatedWork W1967239859 @default.
• W2010432185 hasRelatedWork W1968296544 @default.
• W2010432185 hasRelatedWork W1985327808 @default.
• W2010432185 hasRelatedWork W1986918866 @default.
• W2010432185 hasRelatedWork W1994163427 @default.
• W2010432185 hasRelatedWork W2023221833 @default.
• W2010432185 hasRelatedWork W2031232537 @default.
• W2010432185 hasRelatedWork W2054400702 @default.
• W2010432185 hasRelatedWork W2070019763 @default.
• W2010432185 hasRelatedWork W2070404287 @default.
• W2010432185 hasRelatedWork W2071662250 @default.
• W2010432185 hasRelatedWork W2083803599 @default.
• W2010432185 hasRelatedWork W2099018240 @default.
• W2010432185 hasRelatedWork W2103804399 @default.
• W2010432185 hasRelatedWork W2148402834 @default.
• W2010432185 hasRelatedWork W2315014658 @default.
• W2010432185 hasRelatedWork W2396009925 @default.
• W2010432185 hasRelatedWork W2396747195 @default.
• W2010432185 hasRelatedWork W2771576716 @default.
• W2010432185 hasRelatedWork W3016322114 @default.
• W2010432185 isParatext "false" @default.

• next