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- W2010444205 abstract "Results have been presented to suggest that steroids can inhibit benign mammary fibroadenoma development without exerting significant androgenic or cstrogenic effects in experimental animals. Preliminary observations suggest that the antitumor efficacy of these agents may depend upon their ability to inhibit certain secretory functions of the adenohypophysis. However, direct effects of steroids on tumor growth rate in the absence of the pituitary have not been determined. Final resolution of these questions awaits more detailed investigation in experimental animals and man. Compared with 17-methyltestosterone, llα-hydroxy-17-methyltestosteronc and 9,ll-epoxy-17-methyltestosterone have decreased androgenic activity while their antitumor activity is in a large measure the same. Compared with 19-nortestosterone, 2-methyl-19-nortestosterone has less so-called “masculinizing”ability in female rats, but antitumor activity is substantially the same. Possible mechanisms regarding ability of these steroids to inhi..." @default.
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- W2010444205 date "1959-03-01" @default.
- W2010444205 modified "2023-09-23" @default.
- W2010444205 title "INHIBITION OF MAMMARY FIBROADENOMA OF FEMALE RATS BY STEROIDS OF THE ANDROSTANE SERIES" @default.
- W2010444205 doi "https://doi.org/10.1210/endo-64-3-390" @default.
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