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- W2010451857 abstract "The cell surface protein apolipoprotein I (APOI) is expressed on various cell types including malignant lymphoid cells. Triggering of APOl protein with antibody (Ab) induces apoptosis in APOIexpressing cells. We examined the effect of anti (a) APOl Ab on spontaneous apoptosis (SA) and bcl-2 expression in B cell chronic lymphocytic leukaemia (B-CLL) in virro. We also investigated the anti-apoptotic activity of interleukin 4 (IL4) on the aAPOI-induced apoptosis in B-CLL cells. Although expression of APOl on B-CLL cells was not detectable by immunofluorescence, aAPOl Ab induced apoptosis in these cells. At 24 hours in culture the number of apoptotic cells was increased by a mean percentage (%) of 27% (range: 21-38) in only half of the cases studied. But in all twelve cases studied, at 48 hours aAPO I increased SA by a mean of 72% (range: 26- I 14) (P <. OO I) and at 72 hours, the mean 96 increase was 69% (range: 31-96) in 6/7 cases (P <. OOI). This effect was aAPOl concentration dependent. Interleukin 4 significantly protected B-CLL cells against aAPO I - induced apoptosis by a mean of 53% (range: 28-76) (P c. OOI). This protection was specific to IL4 and it was significantly reduced or abolished with alL4 Ab. Expression of bcl-2 protein in untreated cultures was not significantly different from that of the aAPOI-treated cells; the mean equivalent of soluble fluomhrome (MESF) (range) was 4.9 (3.0-6.8) and 5.2 (3.5-6.0r)e spectively (P > 0.2). In fresh B-CLL cells the MESF (range) was 4.5 (2.4-6.6). Thus aAPOI Ab induced apoptosis in BCLL cells by a pathway that is independent of bcl-2 expression and partially blocked by IL4." @default.
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- W2010451857 title "Effect of anti-APO1 on Spontaneous Apotosis of B Cells in Chronic Lymphocytic Leukaemia: The Role of bel-2 and Interleukin 4" @default.
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- W2010451857 doi "https://doi.org/10.3109/10428199509107902" @default.
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