FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010454048> ?p ?o ?g. }

• W2010454048 endingPage "7917" @default.
• W2010454048 startingPage "7908" @default.
• W2010454048 abstract "The cytochrome (cyt) c1 heme of the ubihydroquinone:cytochrome c oxidoreductase (bc1 complex) is covalently attached to two cysteine residues of the cyt c1 polypeptide chain via two thioether bonds, and the fifth and sixth axial ligands of its iron atom are histidine (H) and methionine (M), respectively. The latter residue is M183 in Rhodobacter capsulatus cyt c1, and previous mutagenesis studies revealed its critical role for the physicochemical properties of cyt c1 [Gray, K. A., Davidson, E., and Daldal, F. (1992) Biochemistry 31, 11864-11873]. In the homologous chloroplast b6f complex, the sixth axial ligand is provided by the amino group of the amino terminal tyrosine residue. To further pursue our investigation on the role played by the sixth axial ligand in heme-protein interactions, novel cyt c1 variants with histidine-lysine (K) and histidine-histidine axial coordination were sought. Using a R. capsulatus genetic system, the cyt c1 mutants M183K and M183H were constructed by site-directed mutagenesis, and chromatophore membranes as well as purified bc1 complexes obtained from these mutants were characterized in detail. The studies revealed that these mutants incorporated the heme group into the mature cyt c1 polypeptides, but yielded nonfunctional bc1 complexes with unusual spectroscopic and thermodynamic properties, including shifted optical absorption maxima (lambdamax) and decreased redox midpoint potential values (Em7). The availability and future detailed studies of these stable cyt c1 mutants should contribute to our understanding of how different factors influence the physicochemical and folding properties of membrane-bound c-type cytochromes in general." @default.
• W2010454048 created "2016-06-24" @default.
• W2010454048 creator A5010318452 @default.
• W2010454048 creator A5027835055 @default.
• W2010454048 creator A5031013438 @default.
• W2010454048 creator A5046786080 @default.
• W2010454048 creator A5073449652 @default.
• W2010454048 creator A5074348258 @default.
• W2010454048 date "1999-05-27" @default.
• W2010454048 modified "2023-10-14" @default.
• W2010454048 title "Substitution of the Sixth Axial Ligand of <i>Rhodobacter capsulatus</i> Cytochrome <i>c</i>₁ Heme Yields Novel Cytochrome <i>c</i>₁ Variants with Unusual Properties" @default.
• W2010454048 cites W1488628742 @default.
• W2010454048 cites W1581924051 @default.
• W2010454048 cites W1775749144 @default.
• W2010454048 cites W1994571394 @default.
• W2010454048 cites W1997323735 @default.
• W2010454048 cites W2048484224 @default.
• W2010454048 cites W2095050532 @default.
• W2010454048 cites W2134895507 @default.
• W2010454048 cites W2145412238 @default.
• W2010454048 cites W2170621128 @default.
• W2010454048 cites W2190148309 @default.
• W2010454048 cites W4246448952 @default.
• W2010454048 doi "https://doi.org/10.1021/bi990211k" @default.
• W2010454048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10387032" @default.
• W2010454048 hasPublicationYear "1999" @default.
• W2010454048 type Work @default.
• W2010454048 sameAs 2010454048 @default.
• W2010454048 citedByCount "16" @default.
• W2010454048 countsByYear W20104540482014 @default.
• W2010454048 countsByYear W20104540482016 @default.
• W2010454048 countsByYear W20104540482017 @default.
• W2010454048 countsByYear W20104540482018 @default.
• W2010454048 countsByYear W20104540482020 @default.
• W2010454048 crossrefType "journal-article" @default.
• W2010454048 hasAuthorship W2010454048A5010318452 @default.
• W2010454048 hasAuthorship W2010454048A5027835055 @default.
• W2010454048 hasAuthorship W2010454048A5031013438 @default.
• W2010454048 hasAuthorship W2010454048A5046786080 @default.
• W2010454048 hasAuthorship W2010454048A5073449652 @default.
• W2010454048 hasAuthorship W2010454048A5074348258 @default.
• W2010454048 hasConcept C104317684 @default.
• W2010454048 hasConcept C116569031 @default.
• W2010454048 hasConcept C143065580 @default.
• W2010454048 hasConcept C170493617 @default.
• W2010454048 hasConcept C181199279 @default.
• W2010454048 hasConcept C185592680 @default.
• W2010454048 hasConcept C2776217839 @default.
• W2010454048 hasConcept C2777850835 @default.
• W2010454048 hasConcept C2778460671 @default.
• W2010454048 hasConcept C2779201268 @default.
• W2010454048 hasConcept C2780768313 @default.
• W2010454048 hasConcept C515207424 @default.
• W2010454048 hasConcept C55493867 @default.
• W2010454048 hasConcept C71240020 @default.
• W2010454048 hasConceptScore W2010454048C104317684 @default.
• W2010454048 hasConceptScore W2010454048C116569031 @default.
• W2010454048 hasConceptScore W2010454048C143065580 @default.
• W2010454048 hasConceptScore W2010454048C170493617 @default.
• W2010454048 hasConceptScore W2010454048C181199279 @default.
• W2010454048 hasConceptScore W2010454048C185592680 @default.
• W2010454048 hasConceptScore W2010454048C2776217839 @default.
• W2010454048 hasConceptScore W2010454048C2777850835 @default.
• W2010454048 hasConceptScore W2010454048C2778460671 @default.
• W2010454048 hasConceptScore W2010454048C2779201268 @default.
• W2010454048 hasConceptScore W2010454048C2780768313 @default.
• W2010454048 hasConceptScore W2010454048C515207424 @default.
• W2010454048 hasConceptScore W2010454048C55493867 @default.
• W2010454048 hasConceptScore W2010454048C71240020 @default.
• W2010454048 hasIssue "25" @default.
• W2010454048 hasLocation W20104540481 @default.
• W2010454048 hasLocation W20104540482 @default.
• W2010454048 hasOpenAccess W2010454048 @default.
• W2010454048 hasPrimaryLocation W20104540481 @default.
• W2010454048 hasRelatedWork W1488229946 @default.
• W2010454048 hasRelatedWork W1589135311 @default.
• W2010454048 hasRelatedWork W1894529473 @default.
• W2010454048 hasRelatedWork W1967305892 @default.
• W2010454048 hasRelatedWork W1983655240 @default.
• W2010454048 hasRelatedWork W2010454048 @default.
• W2010454048 hasRelatedWork W2038038833 @default.
• W2010454048 hasRelatedWork W2090499415 @default.
• W2010454048 hasRelatedWork W2337802850 @default.
• W2010454048 hasRelatedWork W2885499617 @default.
• W2010454048 hasVolume "38" @default.
• W2010454048 isParatext "false" @default.
• W2010454048 isRetracted "false" @default.
• W2010454048 magId "2010454048" @default.
• W2010454048 workType "article" @default.