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- W2010464914 abstract "The majority of thyroid cancers arise from the follicular cells of the thyroid gland, which yield a wide variety of distinct morphotypes, ranging from relatively indolent lesions to the most malignant forms of cancer known. The remaining primary thyroid cancers arise from C cells within the gland and result primarily from mutations of the RET protooncogene, germ line mutations of which give rise to the various forms of multiple endocrine neoplasia. The most common of the follicular cell-derived cancers are papillary carcinomas, (PTC), followed by follicular carcinomas (FTC) and its Hurthle cell variant (HCC) and finally anaplastic carcinomas (ATC). The pathogenesis of many thyroid cancers, of both PTC and FTC morphotype, involves chromosomal translocations. Rearrangements of the RET protoconcogene are known to be involved in the pathogenesis of ca. 50% of PTC. A similar proportion of FTC have been associated with a t(2;3)(q13;p25) translocation, fusing the thyroid-specific transcription factor PAX8 with the peroxisome proliferator-activated receptor gamma (PPARγ) nuclear receptor, a ubiquitously expressed transcription factor. These rearrangements have analogy with translocations in erythropoetic cells, which form the only other known group of human malignancies that are largely the result of chromosomal translocation events. In this review we compare and contrast the oncogenic properties of thyroid and erythroid chromosomal transformations and speculate on mechanisms leading to their formation." @default.
- W2010464914 created "2016-06-24" @default.
- W2010464914 creator A5010329918 @default.
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- W2010464914 creator A5041094047 @default.
- W2010464914 creator A5058620102 @default.
- W2010464914 creator A5073383381 @default.
- W2010464914 date "2007-09-01" @default.
- W2010464914 modified "2023-10-16" @default.
- W2010464914 title "Chromosomal rearrangements and the pathogenesis of differentiated thyroid cancer" @default.
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- W2010464914 doi "https://doi.org/10.1007/s12156-007-0010-8" @default.
- W2010464914 hasPublicationYear "2007" @default.