FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010466025> ?p ?o ?g. }

• W2010466025 endingPage "1862" @default.
• W2010466025 startingPage "1856" @default.
• W2010466025 abstract "No AccessJournal of UrologyInvestigative Urology1 Nov 1998ENDOTHELIN-1 AS A PUTATIVE MODULATOR OF GENE EXPRESSION AND CELLULAR PHYSIOLOGY IN CULTURED HUMAN CORPORAL SMOOTH MUSCLE CELLS ANNAMARIA GIRALDI, SCOTT SERELS, MICHAEL AUTIERI, ARNOLD MELMAN, and GEORGE J. CHRIST ANNAMARIA GIRALDIANNAMARIA GIRALDI More articles by this author , SCOTT SERELSSCOTT SERELS More articles by this author , MICHAEL AUTIERIMICHAEL AUTIERI More articles by this author , ARNOLD MELMANARNOLD MELMAN More articles by this author , and GEORGE J. CHRISTGEORGE J. CHRIST More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62432-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Increases in cytosolic calcium levels trigger smooth muscle contraction while nuclear calcium increases are thought to regulate gene expression. Endothelin-1 (ET-1) affects both. The goal of these studies was to further investigate the importance of ET-1 to corporal physiology by examining its actions on proliferation and immediate early gene (IEG) expression in cultured human corporal smooth muscle cells. Materials & Methods: Early passage (1-3) smooth muscle cells were grown in culture and exposed to either phenylephrine (PE) or ET-1 in the absence and presence of serum, the ETA or ETB selective antagonist BQ123 or IRL1038, or the L-type Ca2+ channel blocker, verapamil. Cell proliferation was assessed with a hemocytometer. The effects of ET-1 on c-myc and c-fos were evaluated using Northern blot analysis. Parametric or nonparametric statistics were used as appropriate. Results: Addition of ET-1 (100 nM) to serum-starved cultured corporal smooth muscle cells was associated with a nearly 2-fold increase in cell number, as well as 2 to 6-fold increases in c-myc and c-fos levels. Cellular proliferation was inhibited by ETA- or ETB-receptor subtype blockade with BQ123 (1 micro M) or IRL1038 (1 micro M), respectively, or blockade of Ca2+ channels with verapamil (10 micro M). PE (3 micro M) had no detectable effect on smooth muscle proliferation. Conclusions: Cell proliferation was mediated by activation of the ETA and ETB receptor subtypes, dependent on transmembrane Ca2+ flux, and correlated with significant increases in c-myc and c-fos mRNA levels. These studies extend previous observations to indicate the potential pleotropic actions of this peptide in the regulation of human corporal smooth muscle physiology in vivo. References 1 : ET-A receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. Br. J. Pharmacol.1995; 115: 191. Google Scholar 2 : Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br. J. Pharmacol.1994; 112: 207. Google Scholar 3 : A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature1988; 332: 411. Crossref, Medline, Google Scholar 4 : Endothelin. J. Cardiovasc. Pharmacol.1991; 18: S15. Google Scholar 5 : Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells. Br. J. Pharmacol.1995; 114: 551. Google Scholar 6 : Hypertension, growth factors, and their relevance to atherosclerotic vascular disease. In: Hypertension: Pathophysiology, Diagnosis, and Management. Edited by . New York: Raven Press, Ltd1995: 515. Google Scholar 7 : Insulin stimulates endothelin binding and action on cultured vascular smooth muscle cells. Endocrinology.1993; 133: 1092. Google Scholar 8 : Morphogenic effects of endothelin-1 on vascular smooth muscle cells. J. Vasc. Res.1993; 30: 192. Google Scholar 9 : High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells. J. Clin. Invest.1994; 93: 1056. Google Scholar 10 : Induction of endothelin secretion by angiotensin II: effects on growth and synthetic activity of vascular smooth muscle cells. J. Cardiovasc. Pharmacol.1991; 17: S96. Google Scholar 11 : Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells. FEBS1990; 267: 16. Google Scholar 12 : Functions mediated by endothelin receptors. In: Endothelin Receptors from the Gene to the Human.. Edited by . Florida: CRC Press, Inc.1995: 1995. Google Scholar 13 : Introduction: Endothelin receptors. In: Endothelin Receptors from the Gene to the Human.. Edited by . Florida: CRC Press, Inc.1995: 1995. Google Scholar 14 : Endothelin-1 as a putative modulator of erectile dysfunction: Characteristics of contraction of isolated corporal tissue strips. J. Urol.1995; 153: 1998. Abstract, Google Scholar 15 : Endothelin-1 as a putative modulator of erectile dysfunction. II. Calcium mobilization in cultured human corporal smooth muscle cells. J. Urol.1995; 154: 1571. Abstract, Google Scholar 16 : Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia1990; 33: 306. Google Scholar 17 : Production of endothelin-1 from the mesenteric arteries of stroptozotocin-induced diabetic rats. Life Sci.1991; 48: 2553. Google Scholar 18 : Plasma endothelin levels in hypertension and chronic renal failure. Hypertension1990; 15: 493. Google Scholar 19 : Actions of endothelin on isolated corpus cavernosum from rabbit and man. Acta Physiol. Scand.1990; 139: 113. Google Scholar 21 : Calcium regulation of immediate-early response genes. Cell Calcium1994; 16: 331. Google Scholar 22 : Regulation of intracellular Ca2+and gene expression by endothelin-1. J. Cardiovasc. Pharmacol1991; 17: S89. Google Scholar 23 : Gap junctions formed of connexin43 are found between smooth muscle cells of human corpus cavernosum. J. Urol.1993; 149: 1568. Google Scholar 24 : Gap junction-mediated intercellular diffusion of Ca2+in cultured human corporal smooth muscle cells. Am. J. Physiol.1992; 263: C373. Google Scholar 25 : Human connexin43 gap junction channel gating: evidence for mode shifts and/or heterogeneity. Am. J. Physiol.1996; 271: C321. Google Scholar 26 : On the putative mechanistic basis for intraoperative propofol-induced penile erections. Int. J. Impotence Res.1997; 9. in press. Google Scholar 27 : Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. Br. J. Pharmacol.1990; 101: 375. Google Scholar 28 : Use of differential display to identify differentially expressed mRNAs induced by rat carotid artery balloon angioplasty. Lab. Invest.1995; 72: 656. Google Scholar 29 : Calcium regulation of gene expression. Adv. Second Mess. Protein Phos. Res.1995; 30: 225. Google Scholar 30 : Growth factor activity of endothelin on vascular smooth muscle. Am. J. Physiol.1990; 258: C408. Google Scholar 31 : Vascular smooth muscle cell differentiation and growth response in hypertension. In: Hypertension: Pathophysiology, Diagnosis, and Management. Edited by . New York: Raven Press, Ltd.1995: 697. Google Scholar 32 : Inhibition of vascular smooth muscle cell proliferation by endothelium-dependent vasodilators. Herz.1992; 17: 291. Google Scholar 33 : Effects of candidate autocrine and paracrine mediators on growth responses in isolated rat arteries. Arterioscler. Thromb.1994; 14: 420. Google Scholar 34 : Remodeling and reparation of the cardiovascular system. J. Am. Coll. Cardiol.1992; 20: 3. Google Scholar 35 : Proliferation and Na+/H+ exchange activation by endothelin in vascular smooth muscle cells. Am. J.Hypertens.1991; 4: 776. Google Scholar 36 : Structural changes in the resistance vessels in human hypertension. In: Hypertension: Pathophysiology, Diagnosis, and Management. Edited by . New York: Raven Press, Ltd1995: 503. Google Scholar 37 : Ultrastructural studies on the phenotypic modulation of human intimal smooth muscle cells. Atherosclerosis1993; 100: 197. Google Scholar 38 : Type I collagen promotes modulation of cultured rabbit arterial smooth muscle cells from a contractile to a synthetic phenotype. Exp. Cell Res.1993; 204: 121. Google Scholar 39 : Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells. Am. J. Physiol.1992; 263: C1295. Google Scholar 40 : Endothelin-mediated stimulation of DNA synthesis in vascular smooth muscle cells. Biochem. Biophys. Res. Commun.1989; 158: 880. Google Scholar 41 : Endothelin stimulates protein synthesis in smooth muscle cells. Am. J. Physiol.1992; 262: E412. Google Scholar 42 : Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis1989; 78: 225. Google Scholar 43 : Role of endothelin-1 in regulating proliferation of cultured rabbit airway smooth muscle cells. Am. J. Physiol.1992; 263: L317. Google Scholar 44 : Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells. Br. J. Pharmacol.1995; 116: 2267. Google Scholar 45 : Effects of endothelin-1 on vascular smooth muscle cell phenotypic differentiation. J. Cardiovasc. Pharmacol1992; 20: S33. Google Scholar 46 : Endothelin-1-mediated vasoconstriction: specific blockade by verapamil. Clin. Pharmacol. Ther.1992; 52: 583. Google Scholar 47 : Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett.1988; 238: 249. Google Scholar 48 : Polar secretion of endothelin-1 by cultured endothelial cells. Proc. Natl. Acad. Sci. USA.1992; 267: 16066. Google Scholar 49 : Endothelin in cardiovascular homeostasis. In: Hypertension: Pathophysiology, Diagnosis, and Management. Edited by . New York: Raven Press, Ltd1995: 1109. Google Scholar 50 : Evidence for a terminal differentiation process in the rat liver. Differentiation1995; 59: 35. Google Scholar From the Departments of Urology and Pathology, Albert Einstein College of Medicine, Bronx, New York, and the Department of Medical Physiology, University of Copenhagen, Denmark© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 160Issue 5November 1998Page: 1856-1862 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information ANNAMARIA GIRALDI More articles by this author SCOTT SERELS More articles by this author MICHAEL AUTIERI More articles by this author ARNOLD MELMAN More articles by this author GEORGE J. CHRIST More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
• W2010466025 created "2016-06-24" @default.
• W2010466025 creator A5005917520 @default.
• W2010466025 creator A5019373727 @default.
• W2010466025 creator A5038534076 @default.
• W2010466025 creator A5046954095 @default.
• W2010466025 creator A5091034590 @default.
• W2010466025 date "1998-11-01" @default.
• W2010466025 modified "2023-09-26" @default.
• W2010466025 title "ENDOTHELIN-1 AS A PUTATIVE MODULATOR OF GENE EXPRESSION AND CELLULAR PHYSIOLOGY IN CULTURED HUMAN CORPORAL SMOOTH MUSCLE CELLS" @default.
• W2010466025 cites W1968709722 @default.
• W2010466025 cites W1973929461 @default.
• W2010466025 cites W1977285365 @default.
• W2010466025 cites W1987692197 @default.
• W2010466025 cites W2007338133 @default.
• W2010466025 cites W2019282948 @default.
• W2010466025 cites W2019805402 @default.
• W2010466025 cites W2033860713 @default.
• W2010466025 cites W2034587587 @default.
• W2010466025 cites W2051640678 @default.
• W2010466025 cites W2055154146 @default.
• W2010466025 cites W2056551448 @default.
• W2010466025 cites W2056896045 @default.
• W2010466025 cites W2056966654 @default.
• W2010466025 cites W2060407689 @default.
• W2010466025 cites W2062669756 @default.
• W2010466025 cites W2063396231 @default.
• W2010466025 cites W2073508835 @default.
• W2010466025 cites W2075052163 @default.
• W2010466025 cites W2077375838 @default.
• W2010466025 cites W2082274811 @default.
• W2010466025 cites W2084016091 @default.
• W2010466025 cites W2093373525 @default.
• W2010466025 cites W2098539128 @default.
• W2010466025 cites W2103295047 @default.
• W2010466025 cites W2118867299 @default.
• W2010466025 cites W2162804111 @default.
• W2010466025 cites W2178728925 @default.
• W2010466025 cites W2312188853 @default.
• W2010466025 cites W2321079144 @default.
• W2010466025 cites W2336208433 @default.
• W2010466025 cites W2407451535 @default.
• W2010466025 cites W2411046006 @default.
• W2010466025 cites W2412059807 @default.
• W2010466025 cites W2415947431 @default.
• W2010466025 cites W2417502329 @default.
• W2010466025 cites W4205854182 @default.
• W2010466025 cites W4245472597 @default.
• W2010466025 cites W64877072 @default.
• W2010466025 doi "https://doi.org/10.1016/s0022-5347(01)62432-7" @default.
• W2010466025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9783974" @default.
• W2010466025 hasPublicationYear "1998" @default.
• W2010466025 type Work @default.
• W2010466025 sameAs 2010466025 @default.
• W2010466025 citedByCount "14" @default.
• W2010466025 countsByYear W20104660252013 @default.
• W2010466025 crossrefType "journal-article" @default.
• W2010466025 hasAuthorship W2010466025A5005917520 @default.
• W2010466025 hasAuthorship W2010466025A5019373727 @default.
• W2010466025 hasAuthorship W2010466025A5038534076 @default.
• W2010466025 hasAuthorship W2010466025A5046954095 @default.
• W2010466025 hasAuthorship W2010466025A5091034590 @default.
• W2010466025 hasConcept C104317684 @default.
• W2010466025 hasConcept C126322002 @default.
• W2010466025 hasConcept C134018914 @default.
• W2010466025 hasConcept C144980905 @default.
• W2010466025 hasConcept C149601957 @default.
• W2010466025 hasConcept C150194340 @default.
• W2010466025 hasConcept C170493617 @default.
• W2010466025 hasConcept C2992686903 @default.
• W2010466025 hasConcept C54355233 @default.
• W2010466025 hasConcept C71924100 @default.
• W2010466025 hasConcept C86803240 @default.
• W2010466025 hasConcept C95444343 @default.
• W2010466025 hasConceptScore W2010466025C104317684 @default.
• W2010466025 hasConceptScore W2010466025C126322002 @default.
• W2010466025 hasConceptScore W2010466025C134018914 @default.
• W2010466025 hasConceptScore W2010466025C144980905 @default.
• W2010466025 hasConceptScore W2010466025C149601957 @default.
• W2010466025 hasConceptScore W2010466025C150194340 @default.
• W2010466025 hasConceptScore W2010466025C170493617 @default.
• W2010466025 hasConceptScore W2010466025C2992686903 @default.
• W2010466025 hasConceptScore W2010466025C54355233 @default.
• W2010466025 hasConceptScore W2010466025C71924100 @default.
• W2010466025 hasConceptScore W2010466025C86803240 @default.
• W2010466025 hasConceptScore W2010466025C95444343 @default.
• W2010466025 hasIssue "5" @default.
• W2010466025 hasLocation W20104660251 @default.
• W2010466025 hasLocation W20104660252 @default.
• W2010466025 hasOpenAccess W2010466025 @default.
• W2010466025 hasPrimaryLocation W20104660251 @default.
• W2010466025 hasRelatedWork W2010305302 @default.
• W2010466025 hasRelatedWork W2047946656 @default.
• W2010466025 hasRelatedWork W2065706314 @default.
• W2010466025 hasRelatedWork W2079115979 @default.
• W2010466025 hasRelatedWork W2370986796 @default.
• W2010466025 hasRelatedWork W2382658166 @default.
• W2010466025 hasRelatedWork W2433780192 @default.

• next