Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010469304> ?p ?o ?g. }
- W2010469304 endingPage "590" @default.
- W2010469304 startingPage "581" @default.
- W2010469304 abstract "Compared to the better-known mu opioid receptor, delta opioid receptors have been relatively understudied. However, the development of highly selective delta opioid agonists and the availability of genetic mouse models have extended our knowledge of delta opioid receptors in vivo. Here we review recent developments in the characterization of delta opioid receptor biology and aspects of delta opioid receptor function that have potential for therapeutic targeting. Preclinical data have confirmed that delta opioid receptor activation reduces persistent pain and improves negative emotional states; clinical trials have been initiated to assess the effectiveness of delta opioid agonists in chronic pain and depression. Furthermore, a possible role for these receptors in neuroprotection is being investigated. The usefulness of targeting delta opioid receptors in drug abuse remains open and a role for these receptors in impulse control disorders is emerging. Finally, the recent demonstration of biased agonism at the delta opioid receptor in vivo opens novel perspectives towards targeting specific therapeutic effects through drug design." @default.
- W2010469304 created "2016-06-24" @default.
- W2010469304 creator A5004180652 @default.
- W2010469304 creator A5024812589 @default.
- W2010469304 creator A5031112700 @default.
- W2010469304 creator A5041985407 @default.
- W2010469304 creator A5065566445 @default.
- W2010469304 date "2011-10-01" @default.
- W2010469304 modified "2023-10-14" @default.
- W2010469304 title "The delta opioid receptor: an evolving target for the treatment of brain disorders" @default.
- W2010469304 cites W1505495051 @default.
- W2010469304 cites W1957440102 @default.
- W2010469304 cites W1963874618 @default.
- W2010469304 cites W1966201474 @default.
- W2010469304 cites W1966834285 @default.
- W2010469304 cites W1967262742 @default.
- W2010469304 cites W1967519053 @default.
- W2010469304 cites W1968201480 @default.
- W2010469304 cites W1977014151 @default.
- W2010469304 cites W1978835714 @default.
- W2010469304 cites W1981568254 @default.
- W2010469304 cites W1982117704 @default.
- W2010469304 cites W1984316985 @default.
- W2010469304 cites W1986682253 @default.
- W2010469304 cites W1989199527 @default.
- W2010469304 cites W1992056759 @default.
- W2010469304 cites W1992190678 @default.
- W2010469304 cites W1997398295 @default.
- W2010469304 cites W1997573390 @default.
- W2010469304 cites W1998450655 @default.
- W2010469304 cites W1999830266 @default.
- W2010469304 cites W2002911679 @default.
- W2010469304 cites W2003714509 @default.
- W2010469304 cites W2004696557 @default.
- W2010469304 cites W2005492665 @default.
- W2010469304 cites W2009134620 @default.
- W2010469304 cites W2010654991 @default.
- W2010469304 cites W2012310516 @default.
- W2010469304 cites W2014790939 @default.
- W2010469304 cites W2014862375 @default.
- W2010469304 cites W2015495093 @default.
- W2010469304 cites W2015647807 @default.
- W2010469304 cites W2016589872 @default.
- W2010469304 cites W2017904157 @default.
- W2010469304 cites W2018005744 @default.
- W2010469304 cites W2018081665 @default.
- W2010469304 cites W2019397294 @default.
- W2010469304 cites W2021128306 @default.
- W2010469304 cites W2025046733 @default.
- W2010469304 cites W2027937624 @default.
- W2010469304 cites W2028772329 @default.
- W2010469304 cites W2029584624 @default.
- W2010469304 cites W2031786762 @default.
- W2010469304 cites W2032348255 @default.
- W2010469304 cites W2038069426 @default.
- W2010469304 cites W2038521791 @default.
- W2010469304 cites W2040669074 @default.
- W2010469304 cites W2041155806 @default.
- W2010469304 cites W2042926513 @default.
- W2010469304 cites W2046575392 @default.
- W2010469304 cites W2047316114 @default.
- W2010469304 cites W2052033071 @default.
- W2010469304 cites W2052717003 @default.
- W2010469304 cites W2053855385 @default.
- W2010469304 cites W2054154085 @default.
- W2010469304 cites W2054883747 @default.
- W2010469304 cites W2058068808 @default.
- W2010469304 cites W2058753935 @default.
- W2010469304 cites W2059769876 @default.
- W2010469304 cites W2061382162 @default.
- W2010469304 cites W2064105042 @default.
- W2010469304 cites W2064284932 @default.
- W2010469304 cites W2064364176 @default.
- W2010469304 cites W2067242528 @default.
- W2010469304 cites W2072149549 @default.
- W2010469304 cites W2072807884 @default.
- W2010469304 cites W2072916781 @default.
- W2010469304 cites W2073947022 @default.
- W2010469304 cites W2075599201 @default.
- W2010469304 cites W2076650614 @default.
- W2010469304 cites W2076685644 @default.
- W2010469304 cites W2076687314 @default.
- W2010469304 cites W2077225773 @default.
- W2010469304 cites W2077783303 @default.
- W2010469304 cites W2078775383 @default.
- W2010469304 cites W2080297785 @default.
- W2010469304 cites W2080832714 @default.
- W2010469304 cites W2081673063 @default.
- W2010469304 cites W2083558970 @default.
- W2010469304 cites W2085272530 @default.
- W2010469304 cites W2086719493 @default.
- W2010469304 cites W2087575237 @default.
- W2010469304 cites W2091605564 @default.
- W2010469304 cites W2092652976 @default.
- W2010469304 cites W2093065930 @default.
- W2010469304 cites W2094109627 @default.
- W2010469304 cites W2102412754 @default.
- W2010469304 cites W2103464104 @default.