Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010473657> ?p ?o ?g. }
- W2010473657 endingPage "14" @default.
- W2010473657 startingPage "1" @default.
- W2010473657 abstract "The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account that visceral fat plays an essential role in the development of metabolic and cardiovascular diseases. However, MetS cannot be used to assess global CVD risk but is at best one more modifiable CVD risk factor. Thus, global cardiometabolic risk (the global risk of cardiovascular disease resulting from traditional risk factors combined with the additional contribution of the metabolic syndrome and/or insulin resistance) should be considered individually. There is solid evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as MetS. Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. Also, ectopic fat deposition could be deteriorated in the heart components such as (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is reviewed and also discussed are potential underlying mechanisms including adipocytokine, insulin resistance and lipotoxicity." @default.
- W2010473657 created "2016-06-24" @default.
- W2010473657 creator A5037533631 @default.
- W2010473657 creator A5041768552 @default.
- W2010473657 creator A5043952560 @default.
- W2010473657 creator A5044995720 @default.
- W2010473657 creator A5051961527 @default.
- W2010473657 creator A5053781383 @default.
- W2010473657 creator A5062280201 @default.
- W2010473657 creator A5069135348 @default.
- W2010473657 creator A5073291028 @default.
- W2010473657 creator A5078739904 @default.
- W2010473657 creator A5084929040 @default.
- W2010473657 creator A5085075825 @default.
- W2010473657 creator A5087029570 @default.
- W2010473657 creator A5087893511 @default.
- W2010473657 creator A5091249720 @default.
- W2010473657 date "2013-01-01" @default.
- W2010473657 modified "2023-10-14" @default.
- W2010473657 title "Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine" @default.
- W2010473657 cites W1554005703 @default.
- W2010473657 cites W1943316683 @default.
- W2010473657 cites W1963736707 @default.
- W2010473657 cites W1965569235 @default.
- W2010473657 cites W1966337856 @default.
- W2010473657 cites W1971404519 @default.
- W2010473657 cites W1973462751 @default.
- W2010473657 cites W1993663878 @default.
- W2010473657 cites W1994291717 @default.
- W2010473657 cites W2004820940 @default.
- W2010473657 cites W2006205217 @default.
- W2010473657 cites W2007981595 @default.
- W2010473657 cites W2009636040 @default.
- W2010473657 cites W2010305313 @default.
- W2010473657 cites W2010586985 @default.
- W2010473657 cites W2020468088 @default.
- W2010473657 cites W2024884385 @default.
- W2010473657 cites W2025355232 @default.
- W2010473657 cites W2033989169 @default.
- W2010473657 cites W2037219183 @default.
- W2010473657 cites W2041475214 @default.
- W2010473657 cites W2050044059 @default.
- W2010473657 cites W2052055930 @default.
- W2010473657 cites W2053965920 @default.
- W2010473657 cites W2056041435 @default.
- W2010473657 cites W2057144817 @default.
- W2010473657 cites W2067086317 @default.
- W2010473657 cites W2072031497 @default.
- W2010473657 cites W2073852966 @default.
- W2010473657 cites W2074987538 @default.
- W2010473657 cites W2076310317 @default.
- W2010473657 cites W2076893110 @default.
- W2010473657 cites W2082053713 @default.
- W2010473657 cites W2085085502 @default.
- W2010473657 cites W2087666481 @default.
- W2010473657 cites W2088118463 @default.
- W2010473657 cites W2091424052 @default.
- W2010473657 cites W2092441434 @default.
- W2010473657 cites W2094941678 @default.
- W2010473657 cites W2096048424 @default.
- W2010473657 cites W2096949413 @default.
- W2010473657 cites W2102797065 @default.
- W2010473657 cites W2102844001 @default.
- W2010473657 cites W2103613140 @default.
- W2010473657 cites W2103941970 @default.
- W2010473657 cites W2105641300 @default.
- W2010473657 cites W2107165713 @default.
- W2010473657 cites W2110909360 @default.
- W2010473657 cites W2113329326 @default.
- W2010473657 cites W2120862552 @default.
- W2010473657 cites W2124263104 @default.
- W2010473657 cites W2124821727 @default.
- W2010473657 cites W2129179042 @default.
- W2010473657 cites W2129233331 @default.
- W2010473657 cites W2129649416 @default.
- W2010473657 cites W2138753092 @default.
- W2010473657 cites W2138936938 @default.
- W2010473657 cites W2139682187 @default.
- W2010473657 cites W2144663588 @default.
- W2010473657 cites W2145470660 @default.
- W2010473657 cites W2153250788 @default.
- W2010473657 cites W2154024456 @default.
- W2010473657 cites W2155121555 @default.
- W2010473657 cites W2156749354 @default.
- W2010473657 cites W2158253017 @default.
- W2010473657 cites W2160832007 @default.
- W2010473657 cites W2161169144 @default.
- W2010473657 cites W2162176594 @default.
- W2010473657 cites W2162655989 @default.
- W2010473657 cites W2165303473 @default.
- W2010473657 cites W2166788192 @default.
- W2010473657 cites W2171233986 @default.
- W2010473657 cites W2324841714 @default.
- W2010473657 cites W4210956151 @default.
- W2010473657 cites W4254261652 @default.
- W2010473657 cites W4376849766 @default.
- W2010473657 cites W980501232 @default.
- W2010473657 doi "https://doi.org/10.2152/jmi.60.1" @default.