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• W2010478829 endingPage "372" @default.
• W2010478829 startingPage "355" @default.
• W2010478829 abstract "We have examined the age-related reordering of optic axons as they pass through the chiasmatic region in fetal ferrets. Proportions of young and old optic axons were determined from electron micrographs taken sequentially through the prechiasmatic nerve, chiasm, and tract. This chronotopic reordering of axons was shown to emerge gradually, beginning rostral to the fusion of the two optic nerves, but continuing to develop caudal to the chiasmatic midline. Segregation of young from old optic axons was most pronounced within the optic tract. We then compared the emergence of this fiber reorganization to the distribution of cell adhesion and extracellular matrix molecules and to the glial architecture within the pathway. Using immunohistochemistry, the distributions of the cell adhesion molecules L1, NCAM, and TAG-1 and the extracellular matrix molecules laminin-1 and chondroitin sulfate proteoglycans (CSPGs) were determined. Among these, only the distribution of CSPGs was observed to change in a manner that complemented the segregation of young from old optic axons. CSPGs were densest in the deeper parts of the optic tract, coincident with radial glial fibers that turn to course within the region of the oldest optic axons. Both the glial architecture and the CSPG distribution form as a consequence of the invasion of the first optic axons, shown by the developmental sequence of each, and by the fact that these glial and molecular features fail to form in the absence of optic axons. The data suggest a model in which the gradient of CSPGs across the depth of the tract contributes to the formation of the chronotopic fiber reordering by providing a relatively unfavorable environment for subsequent axonal growth. The CSPGs may do so by interfering with adhesion molecules on optic axons that normally promote elongation." @default.
• W2010478829 created "2016-06-24" @default.
• W2010478829 creator A5001776497 @default.
• W2010478829 creator A5036339653 @default.
• W2010478829 creator A5059554669 @default.
• W2010478829 creator A5070206059 @default.
• W2010478829 date "1997-04-14" @default.
• W2010478829 modified "2023-10-18" @default.
• W2010478829 title "Chronotopic fiber reordering and the distribution of cell adhesion and extracellular matrix molecules in the optic pathway of fetal ferrets" @default.
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• W2010478829 doi "https://doi.org/10.1002/(sici)1096-9861(19970414)380:3<355::aid-cne5>3.0.co;2-1" @default.
• W2010478829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9087518" @default.
• W2010478829 hasPublicationYear "1997" @default.
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