FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010481489> ?p ?o ?g. }

• W2010481489 endingPage "60" @default.
• W2010481489 startingPage "57" @default.
• W2010481489 abstract "PHYLPA, a unique Physarum lysophosphatidic acid (LPA), showed selective inhibition of a family of DNA polymerase α, including DNA polymerases α, δ and ε; but no inhibition of DNA polymerase β or γ was observed. To reveal the molecular mechanism of inhibition of DNA polymerases by PHYLPA, four stereoisomers and some other derivatives were synthesized and their effects on DNA polymerases were studied. Among eight derivatives synthesized, PHYLPA-1 (the natural PHYLPA; sodium 1- O [(9′ S, 10′ R )-9′, 10′-methanohexadecanoyl]- sn -glycerol 2,3-cyclic phosphate) and PHYLPA-2 ( sodium 3-0-[(9′ S, 10′ R )-9′, 10′-methanohexadecanoyl]- sn -glycerol 1,2-cyclic phosphate) were strong and specific inhibitors of a family of DNA polymerase a. But their stereoisomers PHYLPA-3 (sodium 1-0-[(9′ R , 10′ S )-9′, 10′-methanohexadecanoyl]- sn -glycerol 2,3-cyclic phosphate) and PHYLPA-4 (sodium 3- O -[(9′ R , 10′ S )-9′, 10′-methanohexadecanoyl- sn -glycerol 1,2-cyclic phosphate) were weak inhibitors, showing the critical importance of stereochemistry of a cyclopropane-containing fatty acid for the inhibitory activity. Some derivatives having no cyclopropane-containing fatty acids — palmitoyl-, oleoyl-, and palmitoleoyl-PHYLPA -showed inhibition to some extent; but 1-palmytoyl and 1-oleoyl lysophosphatidic acid, which has no cyclic phosphate, did not show an apparent inhibitor activity on DNA polymerases. Hence, the extent of the inhibition apparently depends on the stereochemistry of both the fatty acid moiety and the cyclic phosphate." @default.
• W2010481489 created "2016-06-24" @default.
• W2010481489 creator A5000782565 @default.
• W2010481489 creator A5005341788 @default.
• W2010481489 creator A5014559042 @default.
• W2010481489 creator A5019068924 @default.
• W2010481489 creator A5037571721 @default.
• W2010481489 creator A5058678315 @default.
• W2010481489 creator A5062505521 @default.
• W2010481489 creator A5066269606 @default.
• W2010481489 date "1995-08-01" @default.
• W2010481489 modified "2023-10-01" @default.
• W2010481489 title "Selective inhibition of DNA polymerase-α family with chemically synthesized derivatives of PHYLPA, a unique Physarum lysophosphatidic acid" @default.
• W2010481489 cites W1512600725 @default.
• W2010481489 cites W1521786414 @default.
• W2010481489 cites W1531820450 @default.
• W2010481489 cites W1575016271 @default.
• W2010481489 cites W1602862920 @default.
• W2010481489 cites W1627099483 @default.
• W2010481489 cites W1664264312 @default.
• W2010481489 cites W1776576701 @default.
• W2010481489 cites W1917953430 @default.
• W2010481489 cites W1966839649 @default.
• W2010481489 cites W1996978486 @default.
• W2010481489 cites W2029921454 @default.
• W2010481489 cites W2042481870 @default.
• W2010481489 cites W2068106019 @default.
• W2010481489 cites W2070468978 @default.
• W2010481489 cites W2074358033 @default.
• W2010481489 cites W2101533371 @default.
• W2010481489 cites W2149439788 @default.
• W2010481489 cites W2416892638 @default.
• W2010481489 cites W2739902558 @default.
• W2010481489 cites W567975312 @default.
• W2010481489 doi "https://doi.org/10.1016/0005-2760(95)00097-v" @default.
• W2010481489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7654781" @default.
• W2010481489 hasPublicationYear "1995" @default.
• W2010481489 type Work @default.
• W2010481489 sameAs 2010481489 @default.
• W2010481489 citedByCount "25" @default.
• W2010481489 countsByYear W20104814892012 @default.
• W2010481489 countsByYear W20104814892013 @default.
• W2010481489 countsByYear W20104814892014 @default.
• W2010481489 countsByYear W20104814892017 @default.
• W2010481489 countsByYear W20104814892022 @default.
• W2010481489 crossrefType "journal-article" @default.
• W2010481489 hasAuthorship W2010481489A5000782565 @default.
• W2010481489 hasAuthorship W2010481489A5005341788 @default.
• W2010481489 hasAuthorship W2010481489A5014559042 @default.
• W2010481489 hasAuthorship W2010481489A5019068924 @default.
• W2010481489 hasAuthorship W2010481489A5037571721 @default.
• W2010481489 hasAuthorship W2010481489A5058678315 @default.
• W2010481489 hasAuthorship W2010481489A5062505521 @default.
• W2010481489 hasAuthorship W2010481489A5066269606 @default.
• W2010481489 hasConcept C170493617 @default.
• W2010481489 hasConcept C178790620 @default.
• W2010481489 hasConcept C185592680 @default.
• W2010481489 hasConcept C2756471 @default.
• W2010481489 hasConcept C2776661833 @default.
• W2010481489 hasConcept C2777132085 @default.
• W2010481489 hasConcept C2778153493 @default.
• W2010481489 hasConcept C2779200411 @default.
• W2010481489 hasConcept C2780378348 @default.
• W2010481489 hasConcept C2780855919 @default.
• W2010481489 hasConcept C2780881558 @default.
• W2010481489 hasConcept C537181965 @default.
• W2010481489 hasConcept C552990157 @default.
• W2010481489 hasConcept C55493867 @default.
• W2010481489 hasConcept C71240020 @default.
• W2010481489 hasConcept C82381507 @default.
• W2010481489 hasConcept C86803240 @default.
• W2010481489 hasConceptScore W2010481489C170493617 @default.
• W2010481489 hasConceptScore W2010481489C178790620 @default.
• W2010481489 hasConceptScore W2010481489C185592680 @default.
• W2010481489 hasConceptScore W2010481489C2756471 @default.
• W2010481489 hasConceptScore W2010481489C2776661833 @default.
• W2010481489 hasConceptScore W2010481489C2777132085 @default.
• W2010481489 hasConceptScore W2010481489C2778153493 @default.
• W2010481489 hasConceptScore W2010481489C2779200411 @default.
• W2010481489 hasConceptScore W2010481489C2780378348 @default.
• W2010481489 hasConceptScore W2010481489C2780855919 @default.
• W2010481489 hasConceptScore W2010481489C2780881558 @default.
• W2010481489 hasConceptScore W2010481489C537181965 @default.
• W2010481489 hasConceptScore W2010481489C552990157 @default.
• W2010481489 hasConceptScore W2010481489C55493867 @default.
• W2010481489 hasConceptScore W2010481489C71240020 @default.
• W2010481489 hasConceptScore W2010481489C82381507 @default.
• W2010481489 hasConceptScore W2010481489C86803240 @default.
• W2010481489 hasIssue "1" @default.
• W2010481489 hasLocation W20104814891 @default.
• W2010481489 hasLocation W20104814892 @default.
• W2010481489 hasOpenAccess W2010481489 @default.
• W2010481489 hasPrimaryLocation W20104814891 @default.
• W2010481489 hasRelatedWork W1511450533 @default.
• W2010481489 hasRelatedWork W1517388712 @default.
• W2010481489 hasRelatedWork W1610438175 @default.
• W2010481489 hasRelatedWork W1716923782 @default.
• W2010481489 hasRelatedWork W1997322450 @default.

• next