FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010482023> ?p ?o ?g. }

• W2010482023 endingPage "e54545" @default.
• W2010482023 startingPage "e54545" @default.
• W2010482023 abstract "Substantial evidence supports a role for myocyte enhancer factor 2 (MEF2)-mediated transcription in neuronal survival, differentiation and synaptic function. In developing neurons, it has been shown that MEF2-dependent transcription is regulated by neurotrophins. Despite these observations, little is known about the cellular mechanisms by which neurotrophins activate MEF2 transcriptional activity. In this study, we examined the role of salt-inducible kinase 1 (SIK1), a member of the AMP-activated protein kinase (AMPK) family, in the regulation of MEF2-mediated transcription by the neurotrophin brain-derived neurotrophic factor (BDNF). We show that BDNF increases the expression of SIK1 in primary cultures of rat cortical neurons through the extracellular signal-regulated kinase 1/2 (ERK1/2)-signaling pathway. In addition to inducing SIK1 expression, BDNF triggers the phosphorylation of SIK1 at Thr182 and its translocation from the cytoplasm to the nucleus of cortical neurons. The effects of BDNF on the expression, phosphorylation and, translocation of SIK1 are followed by the phosphorylation and nuclear export of histone deacetylase 5 (HDAC5). Blockade of SIK activity with a low concentration of staurosporine abolished BDNF-induced phosphorylation and nuclear export of HDAC5 in cortical neurons. Importantly, stimulation of HDAC5 phosphorylation and nuclear export by BDNF is accompanied by the activation of MEF2-mediated transcription, an effect that is suppressed by staurosporine. Consistent with these data, BDNF induces the expression of the MEF2 target genes Arc and Nur77, in a staurosporine-sensitive manner. In further support of the role of SIK1 in the regulation of MEF2-dependent transcription by BDNF, we found that expression of wild-type SIK1 or S577A SIK1, a mutated form of SIK1 which is retained in the nucleus of transfected cells, is sufficient to enhance MEF2 transcriptional activity in cortical neurons. Together, these data identify a previously unrecognized mechanism by which SIK1 mediates the activation of MEF2-dependent transcription by BDNF." @default.
• W2010482023 created "2016-06-24" @default.
• W2010482023 creator A5035617751 @default.
• W2010482023 creator A5070929942 @default.
• W2010482023 creator A5078367830 @default.
• W2010482023 date "2013-01-22" @default.
• W2010482023 modified "2023-09-25" @default.
• W2010482023 title "Role of Salt-Inducible Kinase 1 in the Activation of MEF2-Dependent Transcription by BDNF" @default.
• W2010482023 cites W1512646664 @default.
• W2010482023 cites W1529177558 @default.
• W2010482023 cites W1534929410 @default.
• W2010482023 cites W1607547268 @default.
• W2010482023 cites W1608322029 @default.
• W2010482023 cites W1783361713 @default.
• W2010482023 cites W1922713680 @default.
• W2010482023 cites W1965855977 @default.
• W2010482023 cites W1966730374 @default.
• W2010482023 cites W1968800607 @default.
• W2010482023 cites W1978667442 @default.
• W2010482023 cites W1979270142 @default.
• W2010482023 cites W1980968246 @default.
• W2010482023 cites W1984728203 @default.
• W2010482023 cites W1988181440 @default.
• W2010482023 cites W1989673575 @default.
• W2010482023 cites W1990638016 @default.
• W2010482023 cites W1992725701 @default.
• W2010482023 cites W1994668849 @default.
• W2010482023 cites W2002358514 @default.
• W2010482023 cites W2008622025 @default.
• W2010482023 cites W2011182719 @default.
• W2010482023 cites W2011389660 @default.
• W2010482023 cites W2014764883 @default.
• W2010482023 cites W2022814598 @default.
• W2010482023 cites W2024124185 @default.
• W2010482023 cites W2040033061 @default.
• W2010482023 cites W2044702738 @default.
• W2010482023 cites W2045987655 @default.
• W2010482023 cites W2046618695 @default.
• W2010482023 cites W2050642338 @default.
• W2010482023 cites W2059182847 @default.
• W2010482023 cites W2064751459 @default.
• W2010482023 cites W2072387160 @default.
• W2010482023 cites W2097795389 @default.
• W2010482023 cites W2107016002 @default.
• W2010482023 cites W2107277218 @default.
• W2010482023 cites W2108017291 @default.
• W2010482023 cites W2112668580 @default.
• W2010482023 cites W2116631863 @default.
• W2010482023 cites W2120338011 @default.
• W2010482023 cites W2131026799 @default.
• W2010482023 cites W2133260196 @default.
• W2010482023 cites W2138319716 @default.
• W2010482023 cites W2138718238 @default.
• W2010482023 cites W2140371655 @default.
• W2010482023 cites W2141284381 @default.
• W2010482023 cites W2151416733 @default.
• W2010482023 cites W2155852256 @default.
• W2010482023 cites W2159892479 @default.
• W2010482023 cites W2168780144 @default.
• W2010482023 doi "https://doi.org/10.1371/journal.pone.0054545" @default.
• W2010482023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3551851" @default.
• W2010482023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23349925" @default.
• W2010482023 hasPublicationYear "2013" @default.
• W2010482023 type Work @default.
• W2010482023 sameAs 2010482023 @default.
• W2010482023 citedByCount "22" @default.
• W2010482023 countsByYear W20104820232014 @default.
• W2010482023 countsByYear W20104820232015 @default.
• W2010482023 countsByYear W20104820232016 @default.
• W2010482023 countsByYear W20104820232017 @default.
• W2010482023 countsByYear W20104820232019 @default.
• W2010482023 countsByYear W20104820232020 @default.
• W2010482023 countsByYear W20104820232021 @default.
• W2010482023 countsByYear W20104820232022 @default.
• W2010482023 countsByYear W20104820232023 @default.
• W2010482023 crossrefType "journal-article" @default.
• W2010482023 hasAuthorship W2010482023A5035617751 @default.
• W2010482023 hasAuthorship W2010482023A5070929942 @default.
• W2010482023 hasAuthorship W2010482023A5078367830 @default.
• W2010482023 hasBestOaLocation W20104820231 @default.
• W2010482023 hasConcept C104317684 @default.
• W2010482023 hasConcept C111936080 @default.
• W2010482023 hasConcept C11960822 @default.
• W2010482023 hasConcept C160539049 @default.
• W2010482023 hasConcept C1629964 @default.
• W2010482023 hasConcept C170493617 @default.
• W2010482023 hasConcept C27253355 @default.
• W2010482023 hasConcept C2778305200 @default.
• W2010482023 hasConcept C2778790584 @default.
• W2010482023 hasConcept C2779084600 @default.
• W2010482023 hasConcept C51183755 @default.
• W2010482023 hasConcept C55493867 @default.
• W2010482023 hasConcept C64927066 @default.
• W2010482023 hasConcept C86339819 @default.
• W2010482023 hasConcept C86803240 @default.
• W2010482023 hasConcept C95444343 @default.
• W2010482023 hasConcept C97029542 @default.
• W2010482023 hasConceptScore W2010482023C104317684 @default.

• next