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- W2010482030 abstract "Fragile sites are chromosome bands that do not manifest a presumed breakage pattern. Identification of fragile sites is a way to investigate the mechanism of carcinogenesis because the fragility at a specific chromosome position may be the causation of an associated cancer. A problem in the identification of fragile sites is the high false positive rate arising from simultaneously carrying out a large number of significance tests. To control it, we propose to find a reference study to confirm the identification result of an objective study. We utilize the Bayesian concept for linking two studies. Basically, our method demonstrates a conservative way to take account of the prior information of a binomial parameter. The derived estimate of breakage probability can be interpreted as a resampling weighted sample-pooling method. It is applied to confirm the identification of fragile sites for a data set of neuroblastoma patients." @default.
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- W2010482030 date "1998-08-01" @default.
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- W2010482030 title "A Confirmation Analysis Method for Identification of Chromosomal Fragile Sites" @default.
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- W2010482030 doi "https://doi.org/10.1016/s0165-4608(97)00418-4" @default.
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