FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010482918> ?p ?o ?g. }

• W2010482918 endingPage "e0116838" @default.
• W2010482918 startingPage "e0116838" @default.
• W2010482918 abstract "We sought to identify the anti-angiogenic molecule expressed in corneal keratocytes that is responsible for maintaining the avascularity of the cornea.Human umbilical vein endothelial cells (HUVECs) were cultured with either human dermal fibroblasts or with human corneal keratocytes under serum-free conditions. The areas that exhibited blood vessel formation were estimated by immunostaining the cultures with an antitibody against CD31, a blood vessel marker. We also performed microarray gene-expression analysis and selected one molecule, angiopoietin-like 7 (ANGPTL7) for further functional studies conducted with the keratocytes and in vivo in mice.Areas showing blood vessel formation in normal serum-free medium were conditions were markedly smaller when HUVECs were co-cultured with corneal keratocytes than when they were co-cultured with the dermal fibroblasts under the same conditions. Microarray analysis revealed that ANGPTL7 expression was higher in keratocytes than in dermal fibroblasts. In vitro, inhibiting ANGPTL7 expression by using a specific siRNA led to greater tube formation than did the transfection of cells with a control siRNA, and this increase in tube formation was abolished when recombinant ANGPTL7 protein was added to the cultures. In vivo, intrastromal injections of an ANGPTL7 PshRNA into the avascular corneal stroma of mice resulted in the growth of blood vessels.ANGPTL7, which is abundantly expressed in keratocytes, plays a major role in maintaining corneal avascularity and transparency." @default.
• W2010482918 created "2016-06-24" @default.
• W2010482918 creator A5002074496 @default.
• W2010482918 creator A5005230545 @default.
• W2010482918 creator A5016285905 @default.
• W2010482918 creator A5026341814 @default.
• W2010482918 creator A5036135855 @default.
• W2010482918 creator A5045874082 @default.
• W2010482918 creator A5051648592 @default.
• W2010482918 creator A5081340907 @default.
• W2010482918 date "2015-01-26" @default.
• W2010482918 modified "2023-10-01" @default.
• W2010482918 title "Angiopoietin-Like 7 Is an Anti-Angiogenic Protein Required to Prevent Vascularization of the Cornea" @default.
• W2010482918 cites W1514160822 @default.
• W2010482918 cites W1541388648 @default.
• W2010482918 cites W1600721209 @default.
• W2010482918 cites W1869444839 @default.
• W2010482918 cites W1974363007 @default.
• W2010482918 cites W1974975509 @default.
• W2010482918 cites W1999384185 @default.
• W2010482918 cites W2011405727 @default.
• W2010482918 cites W2013426370 @default.
• W2010482918 cites W2015713190 @default.
• W2010482918 cites W2045236756 @default.
• W2010482918 cites W2052351336 @default.
• W2010482918 cites W2063220248 @default.
• W2010482918 cites W2070033414 @default.
• W2010482918 cites W2070264842 @default.
• W2010482918 cites W2071830305 @default.
• W2010482918 cites W2081455569 @default.
• W2010482918 cites W2119068010 @default.
• W2010482918 cites W2136188592 @default.
• W2010482918 cites W2142045682 @default.
• W2010482918 cites W2166841658 @default.
• W2010482918 cites W2334349989 @default.
• W2010482918 cites W2395575494 @default.
• W2010482918 cites W61254631 @default.
• W2010482918 cites W8003038 @default.
• W2010482918 doi "https://doi.org/10.1371/journal.pone.0116838" @default.
• W2010482918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4306551" @default.
• W2010482918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25622036" @default.
• W2010482918 hasPublicationYear "2015" @default.
• W2010482918 type Work @default.
• W2010482918 sameAs 2010482918 @default.
• W2010482918 citedByCount "23" @default.
• W2010482918 countsByYear W20104829182016 @default.
• W2010482918 countsByYear W20104829182017 @default.
• W2010482918 countsByYear W20104829182018 @default.
• W2010482918 countsByYear W20104829182020 @default.
• W2010482918 countsByYear W20104829182021 @default.
• W2010482918 countsByYear W20104829182022 @default.
• W2010482918 countsByYear W20104829182023 @default.
• W2010482918 crossrefType "journal-article" @default.
• W2010482918 hasAuthorship W2010482918A5002074496 @default.
• W2010482918 hasAuthorship W2010482918A5005230545 @default.
• W2010482918 hasAuthorship W2010482918A5016285905 @default.
• W2010482918 hasAuthorship W2010482918A5026341814 @default.
• W2010482918 hasAuthorship W2010482918A5036135855 @default.
• W2010482918 hasAuthorship W2010482918A5045874082 @default.
• W2010482918 hasAuthorship W2010482918A5051648592 @default.
• W2010482918 hasAuthorship W2010482918A5081340907 @default.
• W2010482918 hasBestOaLocation W20104829181 @default.
• W2010482918 hasConcept C134018914 @default.
• W2010482918 hasConcept C142724271 @default.
• W2010482918 hasConcept C150903083 @default.
• W2010482918 hasConcept C153911025 @default.
• W2010482918 hasConcept C16930146 @default.
• W2010482918 hasConcept C169760540 @default.
• W2010482918 hasConcept C202751555 @default.
• W2010482918 hasConcept C203014093 @default.
• W2010482918 hasConcept C204232928 @default.
• W2010482918 hasConcept C207001950 @default.
• W2010482918 hasConcept C2776882836 @default.
• W2010482918 hasConcept C2777411675 @default.
• W2010482918 hasConcept C2777663904 @default.
• W2010482918 hasConcept C2777844972 @default.
• W2010482918 hasConcept C2778271429 @default.
• W2010482918 hasConcept C2778939058 @default.
• W2010482918 hasConcept C2780394083 @default.
• W2010482918 hasConcept C4224716 @default.
• W2010482918 hasConcept C502942594 @default.
• W2010482918 hasConcept C52124034 @default.
• W2010482918 hasConcept C54009773 @default.
• W2010482918 hasConcept C54355233 @default.
• W2010482918 hasConcept C55493867 @default.
• W2010482918 hasConcept C71924100 @default.
• W2010482918 hasConcept C81885089 @default.
• W2010482918 hasConcept C86803240 @default.
• W2010482918 hasConcept C95444343 @default.
• W2010482918 hasConceptScore W2010482918C134018914 @default.
• W2010482918 hasConceptScore W2010482918C142724271 @default.
• W2010482918 hasConceptScore W2010482918C150903083 @default.
• W2010482918 hasConceptScore W2010482918C153911025 @default.
• W2010482918 hasConceptScore W2010482918C16930146 @default.
• W2010482918 hasConceptScore W2010482918C169760540 @default.
• W2010482918 hasConceptScore W2010482918C202751555 @default.
• W2010482918 hasConceptScore W2010482918C203014093 @default.
• W2010482918 hasConceptScore W2010482918C204232928 @default.

• next