FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010485212> ?p ?o ?g. }

• W2010485212 endingPage "252" @default.
• W2010485212 startingPage "242" @default.
• W2010485212 abstract "Background: Estimating glomerular filtration rate (GFR) in severely ill inpatients is clinically important for therapeutic interventions and prognosis, but notoriously difficult to do accurately. The Modification of Diet in Renal Disease (MDRD) equation and Cockcroft-Gault (CG) formula are widely used to estimate renal function in sick hospitalized patients; however, neither method has been validated in this setting. Methods: Iodine 125-iothalamate clearances (iGFR) performed in 107 sick inpatients with renal dysfunction were compared with estimated GFRs (eGFRs) from the 6- and 4-variable MDRD (MDRD eGFR) and CG (CG eGFR) equations. Results: Mean serum creatinine (SCr) level was 3.5 ± 2.0 mg/dL (309 ± 177 μmol/L), and mean iGFR was 17.1 ± 17.9 mL/min/1.73 m2 (0.29 ± 0.30 mL/s/1.73 m2). Six-variable MDRD eGFR was 22.5 ± 17.4 mL/min/1.73 m2 (0.38 ± 0.29 mL/s/1.73 m2), 4-variable MDRD eGFR was 23.9 ± 16.3 mL/min/1.73 m2 (0.40 ± 0.27 mL/s/1.73 m2), and CG eGFR was 26.0 ± 17.1 mL/min/1.73 m2 (0.43 ± 0.29 mL/s/1.73 m2). Blood urea nitrogen (BUN)/SCr ratios greater than 20 were seen in 58% of patients. Overall, the CG and MDRD equations overestimated iGFR, with poor agreement. Overestimation of at least 25% of measured iGFR was seen in 63%, 67%, and 70% of all inpatients when using the 6-variable MDRD, 4-variable MDRD, and CG equations, respectively. Accuracy of eGFR within 50% of measured iGFR was 55% for the 6-variable MDRD equation, 49% for the 4-variable MDRD equation, and 40% for the CG formula. The performance of both methods deteriorated further in patients with a BUN/SCr ratio greater than 20. Conclusion: Estimation equations are performed poorly compared with iGFR and are not reliable measures of actual level of function in sick hospitalized patients, especially those with a high BUN/SCr ratio. Although use of the 6-variable MDRD equation provides a better estimation of GFR, it still is unsuitable for clinical application in this population. Background: Estimating glomerular filtration rate (GFR) in severely ill inpatients is clinically important for therapeutic interventions and prognosis, but notoriously difficult to do accurately. The Modification of Diet in Renal Disease (MDRD) equation and Cockcroft-Gault (CG) formula are widely used to estimate renal function in sick hospitalized patients; however, neither method has been validated in this setting. Methods: Iodine 125-iothalamate clearances (iGFR) performed in 107 sick inpatients with renal dysfunction were compared with estimated GFRs (eGFRs) from the 6- and 4-variable MDRD (MDRD eGFR) and CG (CG eGFR) equations. Results: Mean serum creatinine (SCr) level was 3.5 ± 2.0 mg/dL (309 ± 177 μmol/L), and mean iGFR was 17.1 ± 17.9 mL/min/1.73 m2 (0.29 ± 0.30 mL/s/1.73 m2). Six-variable MDRD eGFR was 22.5 ± 17.4 mL/min/1.73 m2 (0.38 ± 0.29 mL/s/1.73 m2), 4-variable MDRD eGFR was 23.9 ± 16.3 mL/min/1.73 m2 (0.40 ± 0.27 mL/s/1.73 m2), and CG eGFR was 26.0 ± 17.1 mL/min/1.73 m2 (0.43 ± 0.29 mL/s/1.73 m2). Blood urea nitrogen (BUN)/SCr ratios greater than 20 were seen in 58% of patients. Overall, the CG and MDRD equations overestimated iGFR, with poor agreement. Overestimation of at least 25% of measured iGFR was seen in 63%, 67%, and 70% of all inpatients when using the 6-variable MDRD, 4-variable MDRD, and CG equations, respectively. Accuracy of eGFR within 50% of measured iGFR was 55% for the 6-variable MDRD equation, 49% for the 4-variable MDRD equation, and 40% for the CG formula. The performance of both methods deteriorated further in patients with a BUN/SCr ratio greater than 20. Conclusion: Estimation equations are performed poorly compared with iGFR and are not reliable measures of actual level of function in sick hospitalized patients, especially those with a high BUN/SCr ratio. Although use of the 6-variable MDRD equation provides a better estimation of GFR, it still is unsuitable for clinical application in this population." @default.
• W2010485212 created "2016-06-24" @default.
• W2010485212 creator A5016452405 @default.
• W2010485212 creator A5028223802 @default.
• W2010485212 creator A5030690893 @default.
• W2010485212 creator A5043195515 @default.
• W2010485212 creator A5052402307 @default.
• W2010485212 creator A5079679645 @default.
• W2010485212 creator A5084420734 @default.
• W2010485212 date "2005-08-01" @default.
• W2010485212 modified "2023-09-30" @default.
• W2010485212 title "Performance of the Cockcroft-Gault and Modification of Diet in Renal Disease Equations in Estimating GFR in Ill Hospitalized Patients" @default.
• W2010485212 cites W1550111394 @default.
• W2010485212 cites W1965708830 @default.
• W2010485212 cites W1966337012 @default.
• W2010485212 cites W1966546210 @default.
• W2010485212 cites W1976542982 @default.
• W2010485212 cites W1980848748 @default.
• W2010485212 cites W1989632116 @default.
• W2010485212 cites W1997089745 @default.
• W2010485212 cites W1997820115 @default.
• W2010485212 cites W2000083085 @default.
• W2010485212 cites W2004693666 @default.
• W2010485212 cites W2020128905 @default.
• W2010485212 cites W2036789134 @default.
• W2010485212 cites W2039427330 @default.
• W2010485212 cites W2043539888 @default.
• W2010485212 cites W2055864845 @default.
• W2010485212 cites W2065749193 @default.
• W2010485212 cites W2068718128 @default.
• W2010485212 cites W2069625155 @default.
• W2010485212 cites W2081476373 @default.
• W2010485212 cites W2084692594 @default.
• W2010485212 cites W2092639422 @default.
• W2010485212 cites W2105225330 @default.
• W2010485212 cites W2131625675 @default.
• W2010485212 cites W2140445493 @default.
• W2010485212 cites W2141348928 @default.
• W2010485212 cites W2145101670 @default.
• W2010485212 cites W2149820792 @default.
• W2010485212 cites W2395656666 @default.
• W2010485212 doi "https://doi.org/10.1053/j.ajkd.2005.04.023" @default.
• W2010485212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16112042" @default.
• W2010485212 hasPublicationYear "2005" @default.
• W2010485212 type Work @default.
• W2010485212 sameAs 2010485212 @default.
• W2010485212 citedByCount "203" @default.
• W2010485212 countsByYear W20104852122012 @default.
• W2010485212 countsByYear W20104852122013 @default.
• W2010485212 countsByYear W20104852122014 @default.
• W2010485212 countsByYear W20104852122015 @default.
• W2010485212 countsByYear W20104852122016 @default.
• W2010485212 countsByYear W20104852122017 @default.
• W2010485212 countsByYear W20104852122018 @default.
• W2010485212 countsByYear W20104852122019 @default.
• W2010485212 countsByYear W20104852122020 @default.
• W2010485212 countsByYear W20104852122021 @default.
• W2010485212 countsByYear W20104852122022 @default.
• W2010485212 countsByYear W20104852122023 @default.
• W2010485212 crossrefType "journal-article" @default.
• W2010485212 hasAuthorship W2010485212A5016452405 @default.
• W2010485212 hasAuthorship W2010485212A5028223802 @default.
• W2010485212 hasAuthorship W2010485212A5030690893 @default.
• W2010485212 hasAuthorship W2010485212A5043195515 @default.
• W2010485212 hasAuthorship W2010485212A5052402307 @default.
• W2010485212 hasAuthorship W2010485212A5079679645 @default.
• W2010485212 hasAuthorship W2010485212A5084420734 @default.
• W2010485212 hasConcept C126322002 @default.
• W2010485212 hasConcept C126894567 @default.
• W2010485212 hasConcept C159641895 @default.
• W2010485212 hasConcept C2778176769 @default.
• W2010485212 hasConcept C2780306776 @default.
• W2010485212 hasConcept C71924100 @default.
• W2010485212 hasConceptScore W2010485212C126322002 @default.
• W2010485212 hasConceptScore W2010485212C126894567 @default.
• W2010485212 hasConceptScore W2010485212C159641895 @default.
• W2010485212 hasConceptScore W2010485212C2778176769 @default.
• W2010485212 hasConceptScore W2010485212C2780306776 @default.
• W2010485212 hasConceptScore W2010485212C71924100 @default.
• W2010485212 hasIssue "2" @default.
• W2010485212 hasLocation W20104852121 @default.
• W2010485212 hasLocation W20104852122 @default.
• W2010485212 hasOpenAccess W2010485212 @default.
• W2010485212 hasPrimaryLocation W20104852121 @default.
• W2010485212 hasRelatedWork W1544023406 @default.
• W2010485212 hasRelatedWork W1974378936 @default.
• W2010485212 hasRelatedWork W2046899919 @default.
• W2010485212 hasRelatedWork W2062717800 @default.
• W2010485212 hasRelatedWork W2063107464 @default.
• W2010485212 hasRelatedWork W2095214324 @default.
• W2010485212 hasRelatedWork W2349987816 @default.
• W2010485212 hasRelatedWork W3117263584 @default.
• W2010485212 hasRelatedWork W393698729 @default.
• W2010485212 hasRelatedWork W656697013 @default.
• W2010485212 hasVolume "46" @default.
• W2010485212 isParatext "false" @default.
• W2010485212 isRetracted "false" @default.
• W2010485212 magId "2010485212" @default.

• next