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- W2010485879 abstract "Although treatment for advanced epithelial ovarian cancer has improved over recent years with the introduction of taxane–platinum chemotherapy, the majority of patients will relapse, and in most the disease remains incurable. A thorough understanding of drug resistance mechanisms is needed, as this remains the largest obstacle in treating patients with recurrent disease. Multidrug resistance proteins, mismatch repair processes and alterations in the p53 pathway are examples of properties within tumour cells that may lead to drug resistance. Novel agents designed to circumvent these mechanisms (e.g. PSC 833, ONYX-015 and ADP53) are currently being investigated for ovarian cancer patients. Further improvements may result from the optimisation of existing first-line regimens with more creative schedules, perhaps involving sequential or intraperitoneal administration of existing drugs, and the incorporation of newer noncross-resistant drugs." @default.
- W2010485879 created "2016-06-24" @default.
- W2010485879 creator A5044372455 @default.
- W2010485879 date "2003-12-01" @default.
- W2010485879 modified "2023-10-18" @default.
- W2010485879 title "Resistance to chemotherapy in advanced ovarian cancer: mechanisms and current strategies" @default.
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- W2010485879 doi "https://doi.org/10.1038/sj.bjc.6601497" @default.
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