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- W2010486556 abstract "In rats with unilateral electrolytic lesions of the substantia nigra, apomorphine induced ipsilateral rotational behavior that was significantly potentiated by naloxone. Yet, in rats with unilateral chemolytic (6-hydroxydopamine) lesions of the substantia nigra, apomorphine induced dose-dependent contralateral turning that was not influenced by pretreatment with even high doses of naloxone. High performance liquid chromatographic analysis of corpora striata from these rats revealed electrolytically-lesioned animals to have a 60-70% reduction in dopamine content while chemolytically-lesioned animals were virtually completely depleted of dopamine. These results suggest that striatal dopamine may be required for naloxone potentiation of apomorphine-induced effects in the rat rotational behavior paradigm." @default.
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- W2010486556 title "Influence of naloxone upon apomorphine-induced rotational behavior in rats with electrolytic versus chemolytical lesions of the substantia nigra" @default.
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- W2010486556 doi "https://doi.org/10.1016/0031-6989(86)90108-6" @default.
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