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- W2010487784 abstract "Background . Aceclofenac and Pregabalin in combination significantly reduce pain as compared to individual drug in chronic low back pain. Literature reveals that all the reported spectrophotometric methods either need tedious extraction procedures, do not offer high sensitivity, use nonspecific reagent, or recommend the measurement of absorbance in the near UV region where interference most probably occurs that does not offer suitable linearity range. Result . A selective, sensitive, accurate, and precise, high performance liquid chromatographic method with UV detector analysis of Aceclofenac and Pregabalin was investigated. Good chromatographic separation was achieved using an ODS-BP hypersil C 18 column (250 mm × 4.6 mm, i.d., 5 μ m) and a mobile phase consisting of 0.05 M phosphate buffer (KH 2 PO 4 ) (pH 6.0) : methanol (60 : 40, v/v) at a flow rate 1 mL/min. The ultraviolet detector was set at wavelength 218 nm. Retention time for Aceclofenac and Pregabalin was found to be 3.220 and 5.910 min, respectively. Rectilinear relationship with good regression coefficients 0.999 and 0.999 was found over the concentration ranges of 5–25 μ g/mL and 3.75–18.75 μ g/mL for ACF and PGB, respectively, with detection limits 0.64 and 0.35 μ g/mL and quantitation limits 1.95 and 1.06 μ g/mL. Conclusion . The mean percentage recoveries were in the range of 98.45–100.08 and 99.69–100.48 for ACF and PGB, respectively. The developed method was successfully applied to the analysis of the drugs in their commercial tablets." @default.
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- W2010487784 date "2014-12-16" @default.
- W2010487784 modified "2023-09-27" @default.
- W2010487784 title "Practical Implication of Chromatographic Method for Estimation of Aceclofenac and Pregabalin in Bulk and Pharmaceutical Dosage Forms" @default.
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- W2010487784 doi "https://doi.org/10.1155/2014/643027" @default.
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