FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010489045> ?p ?o ?g. }

• W2010489045 endingPage "1531" @default.
• W2010489045 startingPage "1527" @default.
• W2010489045 abstract "Oridonin, an active component isolated from Rabdosia rubescences, has been reported to exhibit antitumor effects, but little is known about its molecular mechanisms of action. In this study, the growth-inhibitory activity of oridonin for L929 cells is in time- and dose-dependent manner. After treatment with various concentrations of oridonin for 12 h, the majority of L929 cells underwent apoptosis as measured by an LDH activity-based assay. Although apoptotic bodies were observed in oridonin-treated L929 cells, DNA fragmentation as a hallmark of apoptosis was not found. The pan-caspase inhibitor, z-VAD, and caspase-3 inhibitor, z-DEVD, sensitized L929 cells to oridonin, however, a PARP inhibitor (DPQ) effectively blocked oridonin-induced cell death. After 12 h treatment, PARP proenzyme was significantly cleaved. This result indicated that oridonin-induced L929 cell death required PARP degradation in a caspase-independent manner. In addition, an MEK/ERK inhibitor (PD98059) markedly blocked oridonin-induced cell death, whereas a p38 inhibitor (SB203580) and JNK inhibitor (SP600125) weakly protected the cells against death. Treatment with 41.2 μM oridonin for 12 h induced significant and persistent ERK activation and p38 inactivation in L929 cells without evident changes in the protein levels. The responsiveness of ERK and p38 to oridonin suggests the involvement of these kinases in this apoptotic process. Moreover, oridonin increased the ratio of Bax/Bcl-2 protein expression, whereas it had no effect on the expression of Bcl-xL. These results indicate that regulation of the Bcl-2 and MAPK families maybe the effector mechanisms of oridonin-induced L929 cell death, independent of the caspase pathway." @default.
• W2010489045 created "2016-06-24" @default.
• W2010489045 creator A5022644338 @default.
• W2010489045 creator A5045272575 @default.
• W2010489045 creator A5075653086 @default.
• W2010489045 creator A5083621975 @default.
• W2010489045 creator A5091089849 @default.
• W2010489045 date "2004-01-01" @default.
• W2010489045 modified "2023-10-06" @default.
• W2010489045 title "Oridonin Induces a Caspase-Independent But Mitochondria- and MAPK-Dependent Cell Death in the Murine Fibrosarcoma Cell Line L929" @default.
• W2010489045 cites W1559565228 @default.
• W2010489045 cites W1604551367 @default.
• W2010489045 cites W1658228410 @default.
• W2010489045 cites W1899552864 @default.
• W2010489045 cites W1964617786 @default.
• W2010489045 cites W1975809028 @default.
• W2010489045 cites W1976385326 @default.
• W2010489045 cites W1982991375 @default.
• W2010489045 cites W2004141049 @default.
• W2010489045 cites W2010298858 @default.
• W2010489045 cites W2033955849 @default.
• W2010489045 cites W2034946903 @default.
• W2010489045 cites W2042760321 @default.
• W2010489045 cites W2061023870 @default.
• W2010489045 cites W2065295487 @default.
• W2010489045 cites W2070862399 @default.
• W2010489045 cites W2081145901 @default.
• W2010489045 cites W2104205504 @default.
• W2010489045 cites W2107588151 @default.
• W2010489045 cites W2123149430 @default.
• W2010489045 cites W2323624371 @default.
• W2010489045 cites W2331569326 @default.
• W2010489045 cites W2601804022 @default.
• W2010489045 doi "https://doi.org/10.1248/bpb.27.1527" @default.
• W2010489045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15467189" @default.
• W2010489045 hasPublicationYear "2004" @default.
• W2010489045 type Work @default.
• W2010489045 sameAs 2010489045 @default.
• W2010489045 citedByCount "40" @default.
• W2010489045 countsByYear W20104890452012 @default.
• W2010489045 countsByYear W20104890452013 @default.
• W2010489045 countsByYear W20104890452014 @default.
• W2010489045 countsByYear W20104890452015 @default.
• W2010489045 countsByYear W20104890452017 @default.
• W2010489045 countsByYear W20104890452018 @default.
• W2010489045 countsByYear W20104890452019 @default.
• W2010489045 countsByYear W20104890452021 @default.
• W2010489045 crossrefType "journal-article" @default.
• W2010489045 hasAuthorship W2010489045A5022644338 @default.
• W2010489045 hasAuthorship W2010489045A5045272575 @default.
• W2010489045 hasAuthorship W2010489045A5075653086 @default.
• W2010489045 hasAuthorship W2010489045A5083621975 @default.
• W2010489045 hasAuthorship W2010489045A5091089849 @default.
• W2010489045 hasBestOaLocation W20104890451 @default.
• W2010489045 hasConcept C12519072 @default.
• W2010489045 hasConcept C153911025 @default.
• W2010489045 hasConcept C182979987 @default.
• W2010489045 hasConcept C184235292 @default.
• W2010489045 hasConcept C185592680 @default.
• W2010489045 hasConcept C190283241 @default.
• W2010489045 hasConcept C2779138821 @default.
• W2010489045 hasConcept C31573885 @default.
• W2010489045 hasConcept C43759708 @default.
• W2010489045 hasConcept C502942594 @default.
• W2010489045 hasConcept C51551487 @default.
• W2010489045 hasConcept C54355233 @default.
• W2010489045 hasConcept C552990157 @default.
• W2010489045 hasConcept C55493867 @default.
• W2010489045 hasConcept C57074206 @default.
• W2010489045 hasConcept C81885089 @default.
• W2010489045 hasConcept C82381507 @default.
• W2010489045 hasConcept C86803240 @default.
• W2010489045 hasConcept C95444343 @default.
• W2010489045 hasConcept C98424977 @default.
• W2010489045 hasConceptScore W2010489045C12519072 @default.
• W2010489045 hasConceptScore W2010489045C153911025 @default.
• W2010489045 hasConceptScore W2010489045C182979987 @default.
• W2010489045 hasConceptScore W2010489045C184235292 @default.
• W2010489045 hasConceptScore W2010489045C185592680 @default.
• W2010489045 hasConceptScore W2010489045C190283241 @default.
• W2010489045 hasConceptScore W2010489045C2779138821 @default.
• W2010489045 hasConceptScore W2010489045C31573885 @default.
• W2010489045 hasConceptScore W2010489045C43759708 @default.
• W2010489045 hasConceptScore W2010489045C502942594 @default.
• W2010489045 hasConceptScore W2010489045C51551487 @default.
• W2010489045 hasConceptScore W2010489045C54355233 @default.
• W2010489045 hasConceptScore W2010489045C552990157 @default.
• W2010489045 hasConceptScore W2010489045C55493867 @default.
• W2010489045 hasConceptScore W2010489045C57074206 @default.
• W2010489045 hasConceptScore W2010489045C81885089 @default.
• W2010489045 hasConceptScore W2010489045C82381507 @default.
• W2010489045 hasConceptScore W2010489045C86803240 @default.
• W2010489045 hasConceptScore W2010489045C95444343 @default.
• W2010489045 hasConceptScore W2010489045C98424977 @default.
• W2010489045 hasIssue "10" @default.
• W2010489045 hasLocation W20104890451 @default.
• W2010489045 hasLocation W20104890452 @default.
• W2010489045 hasOpenAccess W2010489045 @default.

• next