Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010489316> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2010489316 endingPage "276" @default.
- W2010489316 startingPage "221" @default.
- W2010489316 abstract "To determine the relationship between the expression of epidermal growth factor receptor (EGFR) and the presence or type of human papillomavirus (HPV) in cervical squamous intraepithelial lesions (SIL), paired colposcopically directed cervical biopsies were obtained from 88 patients referred for abnormal Papanicolaou smears. One biopsy was formalin-fixed and processed for conventional light microscopy, and the other was immediately frozen. A portion of the frozen tissue was used for Southern blot HPV DNA hybridization and a portion for immunohistochemical studies for EGFR using a monoclonal antibody. Forty-seven cases were SIL and 41 were normal. In 41 (87%) of the cases of SIL and in eight (20%) of the normal cases, HPV DNA was detected. Of the SIL cases, HPV 16 was the most frequently detected type, being present in 12 (25%), followed by 10 (21%) types 31 or 35, nine (19%) types 52 or 56, five (11%) uncharacterized types, three (6%) type 18, and two (4%) multiple types. Regardless of histology, EGFR was detected in all cases. In normal cases, EGFR expression was detected in the basal cells only and in SIL in abnormal proliferating parabasal cells such that it correlated with the grade of SIL. When stratified by grade of SIL, no differential expression of EGFR was seen in cases where HPV was detected; in contrast, in cases where no HPV was detected, no differential expression was seen between cases of different HPV type. Thus, EGFR is expressed by all proliferating squamous epithelial cells and as such correlates with the grade of SIL.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2010489316 created "2016-06-24" @default.
- W2010489316 creator A5003644024 @default.
- W2010489316 creator A5005275599 @default.
- W2010489316 creator A5033719178 @default.
- W2010489316 creator A5048497175 @default.
- W2010489316 creator A5081626750 @default.
- W2010489316 date "1992-07-01" @default.
- W2010489316 modified "2023-10-06" @default.
- W2010489316 title "Epidermal Growth Factor Receptor Expression and the Presence of Human Papillomavirus in Cervical Squamous Intraepithelial Lesions" @default.
- W2010489316 doi "https://doi.org/10.1097/00004347-199207000-00009" @default.
- W2010489316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1328080" @default.
- W2010489316 hasPublicationYear "1992" @default.
- W2010489316 type Work @default.
- W2010489316 sameAs 2010489316 @default.
- W2010489316 citedByCount "29" @default.
- W2010489316 countsByYear W20104893162013 @default.
- W2010489316 countsByYear W20104893162014 @default.
- W2010489316 countsByYear W20104893162016 @default.
- W2010489316 countsByYear W20104893162019 @default.
- W2010489316 countsByYear W20104893162020 @default.
- W2010489316 crossrefType "journal-article" @default.
- W2010489316 hasAuthorship W2010489316A5003644024 @default.
- W2010489316 hasAuthorship W2010489316A5005275599 @default.
- W2010489316 hasAuthorship W2010489316A5033719178 @default.
- W2010489316 hasAuthorship W2010489316A5048497175 @default.
- W2010489316 hasAuthorship W2010489316A5081626750 @default.
- W2010489316 hasConcept C121608353 @default.
- W2010489316 hasConcept C142724271 @default.
- W2010489316 hasConcept C170493617 @default.
- W2010489316 hasConcept C204232928 @default.
- W2010489316 hasConcept C2775934546 @default.
- W2010489316 hasConcept C2776362946 @default.
- W2010489316 hasConcept C2779438470 @default.
- W2010489316 hasConcept C54355233 @default.
- W2010489316 hasConcept C55493867 @default.
- W2010489316 hasConcept C57742111 @default.
- W2010489316 hasConcept C71924100 @default.
- W2010489316 hasConcept C86803240 @default.
- W2010489316 hasConceptScore W2010489316C121608353 @default.
- W2010489316 hasConceptScore W2010489316C142724271 @default.
- W2010489316 hasConceptScore W2010489316C170493617 @default.
- W2010489316 hasConceptScore W2010489316C204232928 @default.
- W2010489316 hasConceptScore W2010489316C2775934546 @default.
- W2010489316 hasConceptScore W2010489316C2776362946 @default.
- W2010489316 hasConceptScore W2010489316C2779438470 @default.
- W2010489316 hasConceptScore W2010489316C54355233 @default.
- W2010489316 hasConceptScore W2010489316C55493867 @default.
- W2010489316 hasConceptScore W2010489316C57742111 @default.
- W2010489316 hasConceptScore W2010489316C71924100 @default.
- W2010489316 hasConceptScore W2010489316C86803240 @default.
- W2010489316 hasIssue "3" @default.
- W2010489316 hasLocation W20104893161 @default.
- W2010489316 hasLocation W20104893162 @default.
- W2010489316 hasOpenAccess W2010489316 @default.
- W2010489316 hasPrimaryLocation W20104893161 @default.
- W2010489316 hasRelatedWork W1503095732 @default.
- W2010489316 hasRelatedWork W1533039032 @default.
- W2010489316 hasRelatedWork W2000885178 @default.
- W2010489316 hasRelatedWork W2026953714 @default.
- W2010489316 hasRelatedWork W2106980433 @default.
- W2010489316 hasRelatedWork W2156915693 @default.
- W2010489316 hasRelatedWork W2408693058 @default.
- W2010489316 hasRelatedWork W2418925764 @default.
- W2010489316 hasRelatedWork W2474332992 @default.
- W2010489316 hasRelatedWork W2571624741 @default.
- W2010489316 hasVolume "11" @default.
- W2010489316 isParatext "false" @default.
- W2010489316 isRetracted "false" @default.
- W2010489316 magId "2010489316" @default.
- W2010489316 workType "article" @default.