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• W2010492745 abstract "Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Eighteen monoquaternary reactivators of acetylcholinesterase with modified side chain were developed in an effort to extend the properties of pralidoxime. The known reactivators (pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) and the prepared compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE. Monoquaternary reactivators were not able to exceed the best known compounds for tabun poisoning, but some of them did show reactivation better or comparable with pralidoxime for paraoxon poisoning. However, extensive differences were found by a SAR study for various side chains on the non-oxime part of the reactivator molecule." @default.
• W2010492745 created "2016-06-24" @default.
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• W2010492745 date "2008-09-01" @default.
• W2010492745 modified "2023-10-17" @default.
• W2010492745 title "Monoquaternary pyridinium salts with modified side chain—synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase" @default.
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• W2010492745 doi "https://doi.org/10.1016/j.bmc.2008.07.036" @default.
• W2010492745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18676153" @default.
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