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• W2010499900 startingPage "10575" @default.
• W2010499900 abstract "Viruses, plasmids, and prions can spread in nature despite being a burden to their hosts. Because a prion arises de novo in more than one in 10 6 yeast cells and spreads to all offspring in meiosis, its absence in wild strains would imply that it has a net deleterious effect on its host. Among 70 wild Saccharomyces strains, we found the [ PIN + ] prion in 11 strains, but the [URE3] and [ PSI + ] prions were uniformly absent. In contrast, the “selfish” 2μ DNA was in 38 wild strains and the selfish RNA replicons L-BC, 20S, and 23S were found in 8, 14, and 1 strains, respectively. The absence of [URE3] and [ PSI + ] in wild strains indicates that each prion has a net deleterious effect on its host." @default.
• W2010499900 created "2016-06-24" @default.
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• W2010499900 date "2005-07-15" @default.
• W2010499900 modified "2023-10-18" @default.
• W2010499900 title "Yeast prions [URE3] and [PSI ⁺ ] are diseases" @default.
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• W2010499900 doi "https://doi.org/10.1073/pnas.0504882102" @default.
• W2010499900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1180808" @default.
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