Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010517816> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2010517816 endingPage "21" @default.
- W2010517816 startingPage "16" @default.
- W2010517816 abstract "Objective—Restenosis secondary to neointimal hyperplasia remains the major limiting factor after vascular interventions. Thrombin generated in high concentrations at the site of vascular injury plays a central role in thrombosis and hemostasis. Thrombin has also been implicated as a mitogen for smooth muscle cell proliferation that contributes to restenosis. This study was designed to determine the effects of a specific thrombin inhibitor on neointimal hyperplasia after balloon injury in a rat carotid artery model. Design—A total of 47 male Sprague–Dawley rats were divided into five groups. All groups underwent balloon injury of the left carotid artery. A specific thrombin inhibitor, inogatran, was given in four different regimens: low and high dose injections, short‐term infusion for 3 h, and long‐term infusion for 1 week. After 2 weeks the animals were killed and the carotid neointima/media area ratio and the luminal narrowing were calculated. Results—All treatments significantly reduced the neointimal hyperplasia. Inogatran given as a long‐term infusion for 1 week had the lowest neointima/media ratio compared with the other groups. The percentage of lumen narrowing was also significantly lower in all treatment groups compared with the control group. Conclusion—A specific direct thrombin inhibitor, inogatran, reduces neointimal hyperplasia after arterial injury in rats. A more prolonged administration of the thrombin inhibitor gave a further reduction of the neointimal hyperplasia. It seems that inhibition of thrombin activity is not only important early after injury, but also later. This could have clinical implications in the treatment of restenosis and needs to be further evaluated." @default.
- W2010517816 created "2016-06-24" @default.
- W2010517816 creator A5012021928 @default.
- W2010517816 creator A5045177805 @default.
- W2010517816 creator A5087544603 @default.
- W2010517816 date "2004-01-01" @default.
- W2010517816 modified "2023-09-26" @default.
- W2010517816 title "Inhibition of neointimal hyperplasia by a specific thrombin inhibitor" @default.
- W2010517816 cites W1969971248 @default.
- W2010517816 cites W1981016564 @default.
- W2010517816 cites W2003676002 @default.
- W2010517816 cites W2015784049 @default.
- W2010517816 cites W2030497421 @default.
- W2010517816 cites W2036330792 @default.
- W2010517816 cites W2039359392 @default.
- W2010517816 cites W2054240124 @default.
- W2010517816 cites W2098541906 @default.
- W2010517816 cites W2104810826 @default.
- W2010517816 cites W2108966217 @default.
- W2010517816 cites W2137570167 @default.
- W2010517816 cites W2335915210 @default.
- W2010517816 doi "https://doi.org/10.1080/14017430310016513" @default.
- W2010517816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15204242" @default.
- W2010517816 hasPublicationYear "2004" @default.
- W2010517816 type Work @default.
- W2010517816 sameAs 2010517816 @default.
- W2010517816 citedByCount "2" @default.
- W2010517816 crossrefType "journal-article" @default.
- W2010517816 hasAuthorship W2010517816A5012021928 @default.
- W2010517816 hasAuthorship W2010517816A5045177805 @default.
- W2010517816 hasAuthorship W2010517816A5087544603 @default.
- W2010517816 hasBestOaLocation W20105178161 @default.
- W2010517816 hasConcept C126322002 @default.
- W2010517816 hasConcept C126894567 @default.
- W2010517816 hasConcept C131631996 @default.
- W2010517816 hasConcept C134018914 @default.
- W2010517816 hasConcept C164705383 @default.
- W2010517816 hasConcept C2776301958 @default.
- W2010517816 hasConcept C2776710957 @default.
- W2010517816 hasConcept C2777292125 @default.
- W2010517816 hasConcept C2777339539 @default.
- W2010517816 hasConcept C2777562237 @default.
- W2010517816 hasConcept C2778095995 @default.
- W2010517816 hasConcept C2778283817 @default.
- W2010517816 hasConcept C2778583881 @default.
- W2010517816 hasConcept C2778810321 @default.
- W2010517816 hasConcept C2779161974 @default.
- W2010517816 hasConcept C2780868729 @default.
- W2010517816 hasConcept C71924100 @default.
- W2010517816 hasConcept C89560881 @default.
- W2010517816 hasConceptScore W2010517816C126322002 @default.
- W2010517816 hasConceptScore W2010517816C126894567 @default.
- W2010517816 hasConceptScore W2010517816C131631996 @default.
- W2010517816 hasConceptScore W2010517816C134018914 @default.
- W2010517816 hasConceptScore W2010517816C164705383 @default.
- W2010517816 hasConceptScore W2010517816C2776301958 @default.
- W2010517816 hasConceptScore W2010517816C2776710957 @default.
- W2010517816 hasConceptScore W2010517816C2777292125 @default.
- W2010517816 hasConceptScore W2010517816C2777339539 @default.
- W2010517816 hasConceptScore W2010517816C2777562237 @default.
- W2010517816 hasConceptScore W2010517816C2778095995 @default.
- W2010517816 hasConceptScore W2010517816C2778283817 @default.
- W2010517816 hasConceptScore W2010517816C2778583881 @default.
- W2010517816 hasConceptScore W2010517816C2778810321 @default.
- W2010517816 hasConceptScore W2010517816C2779161974 @default.
- W2010517816 hasConceptScore W2010517816C2780868729 @default.
- W2010517816 hasConceptScore W2010517816C71924100 @default.
- W2010517816 hasConceptScore W2010517816C89560881 @default.
- W2010517816 hasIssue "1" @default.
- W2010517816 hasLocation W20105178161 @default.
- W2010517816 hasLocation W20105178162 @default.
- W2010517816 hasOpenAccess W2010517816 @default.
- W2010517816 hasPrimaryLocation W20105178161 @default.
- W2010517816 hasRelatedWork W116907376 @default.
- W2010517816 hasRelatedWork W2008932721 @default.
- W2010517816 hasRelatedWork W2010517816 @default.
- W2010517816 hasRelatedWork W2104182514 @default.
- W2010517816 hasRelatedWork W2354393929 @default.
- W2010517816 hasRelatedWork W2358320353 @default.
- W2010517816 hasRelatedWork W2366940552 @default.
- W2010517816 hasRelatedWork W2388480330 @default.
- W2010517816 hasRelatedWork W2800171843 @default.
- W2010517816 hasRelatedWork W87618110 @default.
- W2010517816 hasVolume "38" @default.
- W2010517816 isParatext "false" @default.
- W2010517816 isRetracted "false" @default.
- W2010517816 magId "2010517816" @default.
- W2010517816 workType "article" @default.