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- W2010518541 abstract "Significance Small molecules to target oncogenic signaling cascades in cancer have achieved success in molecularly defined patient subsets. The path to approval is often protracted and plagued with failures. Repositioning Food and Drug Administration-approved drugs with known side effects has become a major focus. Bisphosphonates are a commonly prescribed therapy for osteoporosis and skeletal metastases. The drugs have also been associated with reduced tumor burden in some patients, but the mechanism is unknown. Here we provide evidence that bisphosphonates inhibit the human EGFR (HER) receptor tyrosine kinase, including the commonly mutated forms that drive nonsmall cell lung cancer, as well as a resistance mutation. This new mechanism lays the basis for the future use of bisphosphonates for the prevention and therapy of HER family-driven cancers." @default.
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- W2010518541 date "2014-12-01" @default.
- W2010518541 modified "2023-10-04" @default.
- W2010518541 title "Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer" @default.
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- W2010518541 doi "https://doi.org/10.1073/pnas.1421422111" @default.
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