FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010530108> ?p ?o ?g. }

• W2010530108 endingPage "414" @default.
• W2010530108 startingPage "406" @default.
• W2010530108 abstract "Background Obesity has emerged as a risk factor for the development of asthma and it may also influence asthma control and airway inflammation. However, the role of obesity in severe asthma remains unclear. Thus, our objective was to explore the association between obesity (defined by BMI) and severe asthma. Methods Data from the British Thoracic Society Difficult Asthma Registry were used to compare patient demographics, disease characteristics, and health-care utilization among three BMI categories (normal weight: 18.5-24.99; overweight: 25-29.99; obese: ≥ 30) in a well-characterized group of adults with severe asthma. Results The study population consisted of 666 patients with severe asthma; the group had a median BMI of 29.8 (interquartile range, 22.5-34.0). The obese group exhibited greater asthma medication requirements in terms of maintenance corticosteroid therapy (48.9% vs 40.4% and 34.5% in the overweight and normal-weight groups, respectively), steroid burst therapy, and short-acting β2-agonist use per day. Significant differences were seen with gastroesophageal reflux disease (53.9% vs 48.1% and 39.7% in the overweight and normal weight groups, respectively) and proton pump inhibitor use. Bone density scores were higher in the obese group, while pulmonary function testing revealed a reduced FVC and elevated carbon monoxide transfer coefficient. Serum IgE levels decreased with increasing BMI and the obese group was more likely to report eczema, but less likely to have a history of nasal polyps. Conclusions Patients with severe asthma display particular characteristics according to BMI that support the view that obesity-associated severe asthma may represent a distinct clinical phenotype. Obesity has emerged as a risk factor for the development of asthma and it may also influence asthma control and airway inflammation. However, the role of obesity in severe asthma remains unclear. Thus, our objective was to explore the association between obesity (defined by BMI) and severe asthma. Data from the British Thoracic Society Difficult Asthma Registry were used to compare patient demographics, disease characteristics, and health-care utilization among three BMI categories (normal weight: 18.5-24.99; overweight: 25-29.99; obese: ≥ 30) in a well-characterized group of adults with severe asthma. The study population consisted of 666 patients with severe asthma; the group had a median BMI of 29.8 (interquartile range, 22.5-34.0). The obese group exhibited greater asthma medication requirements in terms of maintenance corticosteroid therapy (48.9% vs 40.4% and 34.5% in the overweight and normal-weight groups, respectively), steroid burst therapy, and short-acting β2-agonist use per day. Significant differences were seen with gastroesophageal reflux disease (53.9% vs 48.1% and 39.7% in the overweight and normal weight groups, respectively) and proton pump inhibitor use. Bone density scores were higher in the obese group, while pulmonary function testing revealed a reduced FVC and elevated carbon monoxide transfer coefficient. Serum IgE levels decreased with increasing BMI and the obese group was more likely to report eczema, but less likely to have a history of nasal polyps. Patients with severe asthma display particular characteristics according to BMI that support the view that obesity-associated severe asthma may represent a distinct clinical phenotype." @default.
• W2010530108 created "2016-06-24" @default.
• W2010530108 creator A5006293998 @default.
• W2010530108 creator A5009454067 @default.
• W2010530108 creator A5011606845 @default.
• W2010530108 creator A5016521386 @default.
• W2010530108 creator A5022389916 @default.
• W2010530108 creator A5025906139 @default.
• W2010530108 creator A5027391901 @default.
• W2010530108 creator A5032140143 @default.
• W2010530108 creator A5035607041 @default.
• W2010530108 creator A5045081171 @default.
• W2010530108 creator A5048320859 @default.
• W2010530108 creator A5054513704 @default.
• W2010530108 creator A5076371917 @default.
• W2010530108 creator A5078058393 @default.
• W2010530108 date "2013-02-01" @default.
• W2010530108 modified "2023-10-13" @default.
• W2010530108 title "Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype" @default.
• W2010530108 cites W1585812603 @default.
• W2010530108 cites W1973228855 @default.
• W2010530108 cites W1992733705 @default.
• W2010530108 cites W2015493089 @default.
• W2010530108 cites W2017253803 @default.
• W2010530108 cites W2034410648 @default.
• W2010530108 cites W2035239105 @default.
• W2010530108 cites W2036894863 @default.
• W2010530108 cites W2042820847 @default.
• W2010530108 cites W2044246400 @default.
• W2010530108 cites W2094558540 @default.
• W2010530108 cites W2106715003 @default.
• W2010530108 cites W2112693061 @default.
• W2010530108 cites W2120660261 @default.
• W2010530108 cites W2123257822 @default.
• W2010530108 cites W2128879211 @default.
• W2010530108 cites W2130783110 @default.
• W2010530108 cites W2134268188 @default.
• W2010530108 cites W2136576396 @default.
• W2010530108 cites W2142302739 @default.
• W2010530108 cites W2143502368 @default.
• W2010530108 cites W2145724381 @default.
• W2010530108 cites W2147489728 @default.
• W2010530108 cites W2147991740 @default.
• W2010530108 cites W2150035260 @default.
• W2010530108 cites W2158263320 @default.
• W2010530108 cites W2159211110 @default.
• W2010530108 cites W2160103886 @default.
• W2010530108 cites W2171464785 @default.
• W2010530108 cites W2308777632 @default.
• W2010530108 cites W2971947803 @default.
• W2010530108 cites W4377077046 @default.
• W2010530108 doi "https://doi.org/10.1378/chest.12-0872" @default.
• W2010530108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23064546" @default.
• W2010530108 hasPublicationYear "2013" @default.
• W2010530108 type Work @default.
• W2010530108 sameAs 2010530108 @default.
• W2010530108 citedByCount "101" @default.
• W2010530108 countsByYear W20105301082013 @default.
• W2010530108 countsByYear W20105301082014 @default.
• W2010530108 countsByYear W20105301082015 @default.
• W2010530108 countsByYear W20105301082016 @default.
• W2010530108 countsByYear W20105301082017 @default.
• W2010530108 countsByYear W20105301082018 @default.
• W2010530108 countsByYear W20105301082019 @default.
• W2010530108 countsByYear W20105301082020 @default.
• W2010530108 countsByYear W20105301082021 @default.
• W2010530108 countsByYear W20105301082022 @default.
• W2010530108 countsByYear W20105301082023 @default.
• W2010530108 crossrefType "journal-article" @default.
• W2010530108 hasAuthorship W2010530108A5006293998 @default.
• W2010530108 hasAuthorship W2010530108A5009454067 @default.
• W2010530108 hasAuthorship W2010530108A5011606845 @default.
• W2010530108 hasAuthorship W2010530108A5016521386 @default.
• W2010530108 hasAuthorship W2010530108A5022389916 @default.
• W2010530108 hasAuthorship W2010530108A5025906139 @default.
• W2010530108 hasAuthorship W2010530108A5027391901 @default.
• W2010530108 hasAuthorship W2010530108A5032140143 @default.
• W2010530108 hasAuthorship W2010530108A5035607041 @default.
• W2010530108 hasAuthorship W2010530108A5045081171 @default.
• W2010530108 hasAuthorship W2010530108A5048320859 @default.
• W2010530108 hasAuthorship W2010530108A5054513704 @default.
• W2010530108 hasAuthorship W2010530108A5076371917 @default.
• W2010530108 hasAuthorship W2010530108A5078058393 @default.
• W2010530108 hasConcept C119060515 @default.
• W2010530108 hasConcept C126322002 @default.
• W2010530108 hasConcept C187212893 @default.
• W2010530108 hasConcept C2776042228 @default.
• W2010530108 hasConcept C2780221984 @default.
• W2010530108 hasConcept C2780586474 @default.
• W2010530108 hasConcept C2908647359 @default.
• W2010530108 hasConcept C511355011 @default.
• W2010530108 hasConcept C71924100 @default.
• W2010530108 hasConcept C75603125 @default.
• W2010530108 hasConcept C99454951 @default.
• W2010530108 hasConceptScore W2010530108C119060515 @default.
• W2010530108 hasConceptScore W2010530108C126322002 @default.
• W2010530108 hasConceptScore W2010530108C187212893 @default.
• W2010530108 hasConceptScore W2010530108C2776042228 @default.

• next