FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010532140> ?p ?o ?g. }

• W2010532140 endingPage "114" @default.
• W2010532140 startingPage "107" @default.
• W2010532140 abstract "Since splenic immune functions are depressed in metestrus females following trauma-hemorrhage, we hypothesized that administration of the androgen receptor antagonist flutamide at the onset of resuscitation will maintain the immune function of the spleen following trauma-hemorrhage. Female C57BL6/J mice (metestrus state, 8-12 weeks old), underwent laparotomy and hemorrhagic shock (35.0+/-5.0 mm Hg for 90 min) and received 17beta-estradiol (50 microg/25 g), flutamide (625 microg/25 g) or 17beta-estradiol+flutamide. Four hours after resuscitation, the in vitro productive capacity of different cytokines (TNF-alpha, IL-6, IL-10, and IFN-gamma) by splenic MPhi and splenocytes were determined by flow cytometry. A significantly decreased cytokine production by both splenocytes and splenic MPhi was observed following trauma-hemorrhage compared to shams. Administration of 17beta-estradiol, flutamide and 17beta-estradiol+flutamide following trauma-hemorrhage resulted in a significant increase in the in vitro IL-6 release by splenic MPhi. The TNF-alpha productive capacity, however, was only restored by 17beta-estradiol and 17beta-estradiol+flutamide administration following trauma-hemorrhage. No significant effect of either treatment was observed with regard to the suppressed splenic MPhi IL-10 release. Anti-CD3 stimulation, administration of 17beta-estradiol and 17beta-estradiol+flutamide, but not the administration of flutamide alone resulted in a significant increased release of TNF-alpha, IL-6 and IFN-gamma compared to vehicle-treated animals. No significant effect of either treatment was found on IL-10 productive capacity. These results collectively suggest that flutamide administration following trauma-hemorrhage in females has beneficial effects on splenic immune function. However, flutamide administration in combination with estrogen does not provide any significant, additional effects over 17beta-estradiol administration alone." @default.
• W2010532140 created "2016-06-24" @default.
• W2010532140 creator A5014749662 @default.
• W2010532140 creator A5053230976 @default.
• W2010532140 creator A5084027124 @default.
• W2010532140 creator A5085171919 @default.
• W2010532140 creator A5090005178 @default.
• W2010532140 creator A5091009587 @default.
• W2010532140 date "2006-11-01" @default.
• W2010532140 modified "2023-09-27" @default.
• W2010532140 title "Effects of 17β-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage" @default.
• W2010532140 cites W1968255783 @default.
• W2010532140 cites W1972794855 @default.
• W2010532140 cites W1976302471 @default.
• W2010532140 cites W1978403014 @default.
• W2010532140 cites W1994702356 @default.
• W2010532140 cites W2001037664 @default.
• W2010532140 cites W2007303949 @default.
• W2010532140 cites W2011193031 @default.
• W2010532140 cites W2016193691 @default.
• W2010532140 cites W2041194473 @default.
• W2010532140 cites W2046881607 @default.
• W2010532140 cites W2061025603 @default.
• W2010532140 cites W2064765218 @default.
• W2010532140 cites W2068233691 @default.
• W2010532140 cites W2070666419 @default.
• W2010532140 cites W2073729932 @default.
• W2010532140 cites W2074618631 @default.
• W2010532140 cites W2080677480 @default.
• W2010532140 cites W2081219601 @default.
• W2010532140 cites W2086595736 @default.
• W2010532140 cites W2088980065 @default.
• W2010532140 cites W2089252536 @default.
• W2010532140 cites W2095093897 @default.
• W2010532140 cites W2099925523 @default.
• W2010532140 cites W2117245343 @default.
• W2010532140 cites W2122802855 @default.
• W2010532140 cites W2123878234 @default.
• W2010532140 cites W2129814782 @default.
• W2010532140 cites W2138845289 @default.
• W2010532140 cites W2143333572 @default.
• W2010532140 cites W2159866427 @default.
• W2010532140 cites W2183749515 @default.
• W2010532140 cites W4294553892 @default.
• W2010532140 doi "https://doi.org/10.1016/j.cyto.2006.11.002" @default.
• W2010532140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17207634" @default.
• W2010532140 hasPublicationYear "2006" @default.
• W2010532140 type Work @default.
• W2010532140 sameAs 2010532140 @default.
• W2010532140 citedByCount "14" @default.
• W2010532140 countsByYear W20105321402012 @default.
• W2010532140 countsByYear W20105321402015 @default.
• W2010532140 countsByYear W20105321402018 @default.
• W2010532140 countsByYear W20105321402020 @default.
• W2010532140 crossrefType "journal-article" @default.
• W2010532140 hasAuthorship W2010532140A5014749662 @default.
• W2010532140 hasAuthorship W2010532140A5053230976 @default.
• W2010532140 hasAuthorship W2010532140A5084027124 @default.
• W2010532140 hasAuthorship W2010532140A5085171919 @default.
• W2010532140 hasAuthorship W2010532140A5090005178 @default.
• W2010532140 hasAuthorship W2010532140A5091009587 @default.
• W2010532140 hasConcept C121608353 @default.
• W2010532140 hasConcept C126322002 @default.
• W2010532140 hasConcept C134018914 @default.
• W2010532140 hasConcept C189976730 @default.
• W2010532140 hasConcept C2778313021 @default.
• W2010532140 hasConcept C2780192828 @default.
• W2010532140 hasConcept C2780931953 @default.
• W2010532140 hasConcept C61367390 @default.
• W2010532140 hasConcept C71924100 @default.
• W2010532140 hasConceptScore W2010532140C121608353 @default.
• W2010532140 hasConceptScore W2010532140C126322002 @default.
• W2010532140 hasConceptScore W2010532140C134018914 @default.
• W2010532140 hasConceptScore W2010532140C189976730 @default.
• W2010532140 hasConceptScore W2010532140C2778313021 @default.
• W2010532140 hasConceptScore W2010532140C2780192828 @default.
• W2010532140 hasConceptScore W2010532140C2780931953 @default.
• W2010532140 hasConceptScore W2010532140C61367390 @default.
• W2010532140 hasConceptScore W2010532140C71924100 @default.
• W2010532140 hasIssue "3-4" @default.
• W2010532140 hasLocation W20105321401 @default.
• W2010532140 hasLocation W20105321402 @default.
• W2010532140 hasOpenAccess W2010532140 @default.
• W2010532140 hasPrimaryLocation W20105321401 @default.
• W2010532140 hasRelatedWork W1967171675 @default.
• W2010532140 hasRelatedWork W1973860147 @default.
• W2010532140 hasRelatedWork W2007301956 @default.
• W2010532140 hasRelatedWork W2011296913 @default.
• W2010532140 hasRelatedWork W2037703644 @default.
• W2010532140 hasRelatedWork W2059070336 @default.
• W2010532140 hasRelatedWork W2068991783 @default.
• W2010532140 hasRelatedWork W2110010322 @default.
• W2010532140 hasRelatedWork W2120226638 @default.
• W2010532140 hasRelatedWork W2134879732 @default.
• W2010532140 hasVolume "36" @default.
• W2010532140 isParatext "false" @default.
• W2010532140 isRetracted "false" @default.
• W2010532140 magId "2010532140" @default.

• next