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• W2010534127 abstract "The full-length cDNAs of woodchuck major histocompatibility complex (MHC) class I (MhcMamo-I or Mamo-I) genes were cloned by using cellular mRNA isolated from the peripheral blood mononuclear cells and liver tissues of woodchucks. DNA sequence analysis of Mamo-I cDNAs revealed that the coding regions of Mamo-I genes were about 1080 bp long, encoding 359 amino acid residues. The deduced amino acid sequences of Mamo-I showed structural features like leader, α1, α2, α3, transmembrane and cytoplasmic domains, similar to their homologues in human and other mammals. Analysis of five full-length clones from unrelated woodchucks indicated a polymorphism within the α1 and α2 domains of Mamo-I heavy chain and a high conservation within the α3 and the transmembrane/cytoplasmic domains. Amino acid residues of the α2 and α3 domains that are supposed to be involved in the binding of MHC class I to CD8 molecule, were largely conserved in Mamo-I genes. Phylogenetic comparison of MHC class I genes of woodchuck and other mammals indicated a close evolutionary relationship between woodchuck and squirrel MHC class I. We tentatively named this region the locus A of Mamo-I genes (Mamo-A). Sequence analysis of 101 clones of α1 and α2 regions derived from 14 woodchucks revealed that at least 14 different alleles within Mamo-A exist. Among these 14 alleles identified so far, Mamo-A*01 and Mamo-A*09 were of the highest frequency of about 21.5% and 14.5%, respectively. Our results indicate that Mamo-I genes are of a similar molecular structure to those of human and other mammals." @default.
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• W2010534127 date "2000-06-01" @default.
• W2010534127 modified "2023-10-14" @default.
• W2010534127 title "Molecular cloning and characterization of major histocompatibility complex class I cDNAs from woodchuck (<i>Marmota monax</i>)" @default.
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• W2010534127 doi "https://doi.org/10.1034/j.1399-0039.2000.550605.x" @default.
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