FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010537804> ?p ?o ?g. }

• W2010537804 endingPage "238" @default.
• W2010537804 startingPage "228" @default.
• W2010537804 abstract "Effects of substance P (SP) and selective tachykinin agonists on neurotransmission at guinea-pig intracardiac ganglia were studied in vitro. Voltage responses of neurons to superfused tachykinins and nerve stimulation were measured using intracellular microelectrodes. Predominant effects of SP (1 μM) were to cause slow depolarization and enable synaptic transmission at low intensities of nerve stimulation. Augmented response to nerve stimulation occurred with 29 of 40 intracardiac neurons (approx. 73%). SP inhibited synaptic transmission at 23% of intracardiac neurons but also caused slow depolarization. Activation of NK3 receptors with 100 nM [MePhe7]neurokinin B caused slow depolarization, enhanced the response of many intracardiac neurons to low intensity nerve stimulation or local application of acetylcholine, and triggered action potentials independent of other stimuli in 6 of 42 neurons. The NK1 agonist [Sar9,Met(O2)11]SP had similar actions but was less effective and did not trigger action potentials independently. Neither selective agonist inhibited cholinergic neurotransmission. We conclude that SP can function as a positive or negative neuromodulator at intracardiac ganglion cells, which could be either efferent neurons or interneurons. Potentiation occurs primarily through NK3 receptors and may enable neuronal responses with less preganglionic nerve activity. Inhibition of neurotransmission by SP is most likely explained by the known blocking action of this peptide at ganglionic nicotine receptors." @default.
• W2010537804 created "2016-06-24" @default.
• W2010537804 creator A5008488759 @default.
• W2010537804 creator A5013354311 @default.
• W2010537804 creator A5090606294 @default.
• W2010537804 date "2005-01-01" @default.
• W2010537804 modified "2023-09-25" @default.
• W2010537804 title "Tachykinin Agonists Modulate Cholinergic Neurotransmission at Guinea-Pig Intracardiac Ganglia" @default.
• W2010537804 cites W17546384 @default.
• W2010537804 cites W1962105746 @default.
• W2010537804 cites W1966193155 @default.
• W2010537804 cites W1968781624 @default.
• W2010537804 cites W1977495357 @default.
• W2010537804 cites W1988003878 @default.
• W2010537804 cites W1988142339 @default.
• W2010537804 cites W1991502528 @default.
• W2010537804 cites W1995575495 @default.
• W2010537804 cites W1998211252 @default.
• W2010537804 cites W1998657985 @default.
• W2010537804 cites W2000885628 @default.
• W2010537804 cites W2004264169 @default.
• W2010537804 cites W2006706649 @default.
• W2010537804 cites W2022759460 @default.
• W2010537804 cites W2024853193 @default.
• W2010537804 cites W2026796874 @default.
• W2010537804 cites W2039310983 @default.
• W2010537804 cites W2054712334 @default.
• W2010537804 cites W2063480380 @default.
• W2010537804 cites W2076282756 @default.
• W2010537804 cites W2084612672 @default.
• W2010537804 cites W2122521547 @default.
• W2010537804 cites W2128512378 @default.
• W2010537804 cites W2157199782 @default.
• W2010537804 cites W2162316700 @default.
• W2010537804 cites W2181484973 @default.
• W2010537804 cites W2201197153 @default.
• W2010537804 cites W2204138544 @default.
• W2010537804 cites W2214068110 @default.
• W2010537804 cites W2266184745 @default.
• W2010537804 cites W2266678863 @default.
• W2010537804 cites W2323492642 @default.
• W2010537804 cites W2416271113 @default.
• W2010537804 cites W2425649105 @default.
• W2010537804 cites W294850814 @default.
• W2010537804 doi "https://doi.org/10.1254/jphs.fp0050437" @default.
• W2010537804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16258231" @default.
• W2010537804 hasPublicationYear "2005" @default.
• W2010537804 type Work @default.
• W2010537804 sameAs 2010537804 @default.
• W2010537804 citedByCount "7" @default.
• W2010537804 countsByYear W20105378042015 @default.
• W2010537804 countsByYear W20105378042019 @default.
• W2010537804 countsByYear W20105378042020 @default.
• W2010537804 countsByYear W20105378042021 @default.
• W2010537804 crossrefType "journal-article" @default.
• W2010537804 hasAuthorship W2010537804A5008488759 @default.
• W2010537804 hasAuthorship W2010537804A5013354311 @default.
• W2010537804 hasAuthorship W2010537804A5090606294 @default.
• W2010537804 hasBestOaLocation W20105378041 @default.
• W2010537804 hasConcept C112592302 @default.
• W2010537804 hasConcept C126322002 @default.
• W2010537804 hasConcept C134018914 @default.
• W2010537804 hasConcept C169760540 @default.
• W2010537804 hasConcept C170493617 @default.
• W2010537804 hasConcept C17077164 @default.
• W2010537804 hasConcept C185592680 @default.
• W2010537804 hasConcept C200170125 @default.
• W2010537804 hasConcept C22885893 @default.
• W2010537804 hasConcept C24998067 @default.
• W2010537804 hasConcept C2775910092 @default.
• W2010537804 hasConcept C2778938600 @default.
• W2010537804 hasConcept C4141045 @default.
• W2010537804 hasConcept C71924100 @default.
• W2010537804 hasConcept C86803240 @default.
• W2010537804 hasConceptScore W2010537804C112592302 @default.
• W2010537804 hasConceptScore W2010537804C126322002 @default.
• W2010537804 hasConceptScore W2010537804C134018914 @default.
• W2010537804 hasConceptScore W2010537804C169760540 @default.
• W2010537804 hasConceptScore W2010537804C170493617 @default.
• W2010537804 hasConceptScore W2010537804C17077164 @default.
• W2010537804 hasConceptScore W2010537804C185592680 @default.
• W2010537804 hasConceptScore W2010537804C200170125 @default.
• W2010537804 hasConceptScore W2010537804C22885893 @default.
• W2010537804 hasConceptScore W2010537804C24998067 @default.
• W2010537804 hasConceptScore W2010537804C2775910092 @default.
• W2010537804 hasConceptScore W2010537804C2778938600 @default.
• W2010537804 hasConceptScore W2010537804C4141045 @default.
• W2010537804 hasConceptScore W2010537804C71924100 @default.
• W2010537804 hasConceptScore W2010537804C86803240 @default.
• W2010537804 hasIssue "3" @default.
• W2010537804 hasLocation W20105378041 @default.
• W2010537804 hasLocation W20105378042 @default.
• W2010537804 hasLocation W20105378043 @default.
• W2010537804 hasOpenAccess W2010537804 @default.
• W2010537804 hasPrimaryLocation W20105378041 @default.
• W2010537804 hasRelatedWork W1984619393 @default.
• W2010537804 hasRelatedWork W1993142192 @default.
• W2010537804 hasRelatedWork W2018345014 @default.

• next