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- W2010545765 abstract "The discovery of activating BRAF mutations in ∼50% of all melanomas has proved to be a turning point in the therapeutic management of the disseminated disease. In this commentary, we review the latest research delineating the role of mutant BRAF in melanoma initiation and progression and discuss the remarkable 10-year journey leading up to the recent U.S. Food and Drug Administration approval of the small-molecule BRAF inhibitor vemurafenib. We further outline the most recent findings on the mechanisms that underlie intrinsic and acquired BRAF inhibitor resistance and describe ongoing preclinical and clinical studies designed to delay or abrogate the onset of therapeutic escape. It is hoped that our evolving understanding of melanoma genetics and intracellular signaling coupled with a growing armamentarium of signal transduction inhibitors will lead to significant improvements in the level and durability of therapeutic response in metastatic melanoma." @default.
- W2010545765 created "2016-06-24" @default.
- W2010545765 creator A5012911914 @default.
- W2010545765 creator A5059758317 @default.
- W2010545765 creator A5066685499 @default.
- W2010545765 date "2012-03-01" @default.
- W2010545765 modified "2023-09-26" @default.
- W2010545765 title "Targeting Mutant BRAF in Melanoma" @default.
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