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- W2010546163 abstract "Microengineered cell culture systems are becoming sufficiently sophisticated that they can recapitulate many of the phenomena observed in tissues and organisms. Here, Huh and colleagues discuss the advances made in these 'organs-on-chips' and how they could be used in drug development, including target identification and validation, toxicity screening and stratified medicine. Improving the effectiveness of preclinical predictions of human drug responses is critical to reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication and microfluidics have enabled the development of microengineered models of the functional units of human organs — known as organs-on-chips — that could provide the basis for preclinical assays with greater predictive power. Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology." @default.
- W2010546163 created "2016-06-24" @default.
- W2010546163 creator A5038826323 @default.
- W2010546163 creator A5054392960 @default.
- W2010546163 creator A5058725999 @default.
- W2010546163 date "2015-03-20" @default.
- W2010546163 modified "2023-10-16" @default.
- W2010546163 title "Organs-on-chips at the frontiers of drug discovery" @default.
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