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- W2010548973 endingPage "e1002473" @default.
- W2010548973 startingPage "e1002473" @default.
- W2010548973 abstract "Upon attachment to their respective receptor, human rhinoviruses (HRVs) are internalized into the host cell via different pathways but undergo similar structural changes. This ultimately results in the delivery of the viral RNA into the cytoplasm for replication. To improve our understanding of the conformational modifications associated with the release of the viral genome, we have determined the X-ray structure at 3.0 Å resolution of the end-stage of HRV2 uncoating, the empty capsid. The structure shows important conformational changes in the capsid protomer. In particular, a hinge movement around the hydrophobic pocket of VP1 allows a coordinated shift of VP2 and VP3. This overall displacement forces a reorganization of the inter-protomer interfaces, resulting in a particle expansion and in the opening of new channels in the capsid core. These new breaches in the capsid, opening one at the base of the canyon and the second at the particle two-fold axes, might act as gates for the externalization of the VP1 N-terminus and the extrusion of the viral RNA, respectively. The structural comparison between native and empty HRV2 particles unveils a number of pH-sensitive amino acid residues, conserved in rhinoviruses, which participate in the structural rearrangements involved in the uncoating process." @default.
- W2010548973 created "2016-06-24" @default.
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- W2010548973 date "2012-01-05" @default.
- W2010548973 modified "2023-10-17" @default.
- W2010548973 title "Insights into Minor Group Rhinovirus Uncoating: The X-ray Structure of the HRV2 Empty Capsid" @default.
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- W2010548973 doi "https://doi.org/10.1371/journal.ppat.1002473" @default.
- W2010548973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3252380" @default.
- W2010548973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22241997" @default.
- W2010548973 hasPublicationYear "2012" @default.
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