Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010557777> ?p ?o ?g. }
- W2010557777 endingPage "181" @default.
- W2010557777 startingPage "175" @default.
- W2010557777 abstract "Results of our previous studies have suggested that enhanced generation of superoxide (O2−) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2− scavenger tempol and the antioxidant apocynin on the development of hypertension. Systolic blood pressure (SBP) was monitored from 30 to 99 days of age in TGR and in normotensive Hannover Sprague–Dawley (HanSD) rats. At the end of the experiment, urinary protein and 8-isoprostane excretion were determined and angiotensin II (ANG II) and malondialdehyde (MDA) levels were measured in kidney and cardiac tissues. Cardiac hypertrophy was assessed as the ratio of left heart ventricle weight to tibia length (LVW/TL). Although tempol and apocynin treatment in TGR significantly decreased 8-isoprostane excretion and MAD tissue concentrations as compared with untreated TGR, it did not alter the course of SBP, LVW/TL ratio, proteinuria or ANG II levels that were enhanced as compared with HanSD rats. Our data suggest that the development of hypertension in TGR is clearly ANG II-dependent but the contribution of oxidative stress to the development of hypertension in this model appears to be negligible." @default.
- W2010557777 created "2016-06-24" @default.
- W2010557777 creator A5015545576 @default.
- W2010557777 creator A5047752690 @default.
- W2010557777 creator A5060420206 @default.
- W2010557777 creator A5061612754 @default.
- W2010557777 creator A5070005942 @default.
- W2010557777 creator A5072638292 @default.
- W2010557777 creator A5072641868 @default.
- W2010557777 creator A5075769187 @default.
- W2010557777 creator A5087425182 @default.
- W2010557777 date "2009-08-01" @default.
- W2010557777 modified "2023-10-18" @default.
- W2010557777 title "Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats" @default.
- W2010557777 cites W1972981377 @default.
- W2010557777 cites W1982318505 @default.
- W2010557777 cites W1984011381 @default.
- W2010557777 cites W1996962736 @default.
- W2010557777 cites W1999921498 @default.
- W2010557777 cites W2000155150 @default.
- W2010557777 cites W2007328856 @default.
- W2010557777 cites W2007523611 @default.
- W2010557777 cites W2009592512 @default.
- W2010557777 cites W2011927381 @default.
- W2010557777 cites W2014895864 @default.
- W2010557777 cites W2016217817 @default.
- W2010557777 cites W2018347538 @default.
- W2010557777 cites W2031111933 @default.
- W2010557777 cites W2034374437 @default.
- W2010557777 cites W2035105779 @default.
- W2010557777 cites W2035747909 @default.
- W2010557777 cites W2036386059 @default.
- W2010557777 cites W2051327245 @default.
- W2010557777 cites W2055262264 @default.
- W2010557777 cites W2059287255 @default.
- W2010557777 cites W2061624989 @default.
- W2010557777 cites W2069972175 @default.
- W2010557777 cites W2072109008 @default.
- W2010557777 cites W2075533409 @default.
- W2010557777 cites W2090016088 @default.
- W2010557777 cites W2090241581 @default.
- W2010557777 cites W2091699483 @default.
- W2010557777 cites W2093586784 @default.
- W2010557777 cites W2096869450 @default.
- W2010557777 cites W2097267275 @default.
- W2010557777 cites W2102140304 @default.
- W2010557777 cites W2102611712 @default.
- W2010557777 cites W2103300387 @default.
- W2010557777 cites W2107683340 @default.
- W2010557777 cites W2109542667 @default.
- W2010557777 cites W2112748083 @default.
- W2010557777 cites W2118092557 @default.
- W2010557777 cites W2123969526 @default.
- W2010557777 cites W2127905773 @default.
- W2010557777 cites W2129139391 @default.
- W2010557777 cites W2133381439 @default.
- W2010557777 cites W2133924990 @default.
- W2010557777 cites W2140424613 @default.
- W2010557777 cites W2147224653 @default.
- W2010557777 cites W2147788935 @default.
- W2010557777 cites W2149517874 @default.
- W2010557777 cites W2158027695 @default.
- W2010557777 cites W2166564743 @default.
- W2010557777 cites W2314029408 @default.
- W2010557777 doi "https://doi.org/10.1016/j.vph.2009.06.001" @default.
- W2010557777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19539780" @default.
- W2010557777 hasPublicationYear "2009" @default.
- W2010557777 type Work @default.
- W2010557777 sameAs 2010557777 @default.
- W2010557777 citedByCount "22" @default.
- W2010557777 countsByYear W20105577772012 @default.
- W2010557777 countsByYear W20105577772013 @default.
- W2010557777 countsByYear W20105577772014 @default.
- W2010557777 countsByYear W20105577772015 @default.
- W2010557777 countsByYear W20105577772016 @default.
- W2010557777 countsByYear W20105577772020 @default.
- W2010557777 countsByYear W20105577772023 @default.
- W2010557777 crossrefType "journal-article" @default.
- W2010557777 hasAuthorship W2010557777A5015545576 @default.
- W2010557777 hasAuthorship W2010557777A5047752690 @default.
- W2010557777 hasAuthorship W2010557777A5060420206 @default.
- W2010557777 hasAuthorship W2010557777A5061612754 @default.
- W2010557777 hasAuthorship W2010557777A5070005942 @default.
- W2010557777 hasAuthorship W2010557777A5072638292 @default.
- W2010557777 hasAuthorship W2010557777A5072641868 @default.
- W2010557777 hasAuthorship W2010557777A5075769187 @default.
- W2010557777 hasAuthorship W2010557777A5087425182 @default.
- W2010557777 hasConcept C126322002 @default.
- W2010557777 hasConcept C134018914 @default.
- W2010557777 hasConcept C185592680 @default.
- W2010557777 hasConcept C2776151105 @default.
- W2010557777 hasConcept C2777209548 @default.
- W2010557777 hasConcept C2778401633 @default.
- W2010557777 hasConcept C2779719074 @default.
- W2010557777 hasConcept C2908929049 @default.
- W2010557777 hasConcept C71924100 @default.
- W2010557777 hasConcept C84393581 @default.
- W2010557777 hasConceptScore W2010557777C126322002 @default.