FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010559442> ?p ?o ?g. }

• W2010559442 endingPage "471" @default.
• W2010559442 startingPage "462" @default.
• W2010559442 abstract "To evaluate a protocol that allowed the successful generation of DC and OVCA cells, fusion of these two cell types and assessment of stimulatory ability of the fusion cells for clinical use.Ovarian cancer (OVCA) cells and dendritic cells (DC) were isolated or generated from 22 patients with OVCA and subsequently fused with PEG. The stimulatory ability of fusion cells including T cell proliferation and induction of cytotocic T lymphocytes (CTL) was assessed. In addition, the impact of radiation, freezing and thawing of the fusion cells was evaluated.OVCA cells derived from 22 patients were successfully fused with autologous DC. The created heterokaryons expressed tumor-associated antigens, such as MUC1 and CA-125, and DC-derived MHC class II and costimulatory molecules. The fusion cells were functional in stimulating the proliferation of autologous T cells. In addition, CD4 and CD8 T cells derived from patients with ovarian cancer were stimulated by fusion cells and produced IFN-gamma as demonstrated with intracellular staining. Significantly, T cells primed by fusion cells produced MHC class I-dependent lysis of autologous ovarian tumor cells. One cycle of fusion-cell stimulation can maintain the CTL activity up to 25 days.The fusion of human OVCA cells and DC created immunogenic cells capable of stimulating CD4 and CD8 T cells. The effects of the processes required for preparing a vaccine for clinical use, including freezing and thawing and irradiation, do not interfere with the immunogenic properties of the fusion cells." @default.
• W2010559442 created "2016-06-24" @default.
• W2010559442 creator A5003016176 @default.
• W2010559442 creator A5011116669 @default.
• W2010559442 creator A5022837627 @default.
• W2010559442 creator A5029980930 @default.
• W2010559442 creator A5053347778 @default.
• W2010559442 creator A5054065628 @default.
• W2010559442 creator A5057817233 @default.
• W2010559442 creator A5058725877 @default.
• W2010559442 creator A5080823174 @default.
• W2010559442 date "2005-11-01" @default.
• W2010559442 modified "2023-09-25" @default.
• W2010559442 title "Assessment of fusion cells from patient-derived ovarian carcinoma cells and dendritic cells as a vaccine for clinical use" @default.
• W2010559442 cites W1740181006 @default.
• W2010559442 cites W1951029407 @default.
• W2010559442 cites W1964416857 @default.
• W2010559442 cites W1966335364 @default.
• W2010559442 cites W1966996035 @default.
• W2010559442 cites W1978416272 @default.
• W2010559442 cites W1983427343 @default.
• W2010559442 cites W1997137343 @default.
• W2010559442 cites W1997152839 @default.
• W2010559442 cites W2002877066 @default.
• W2010559442 cites W2004483492 @default.
• W2010559442 cites W2040874987 @default.
• W2010559442 cites W2067573891 @default.
• W2010559442 cites W2070154027 @default.
• W2010559442 cites W2100200230 @default.
• W2010559442 cites W2109694492 @default.
• W2010559442 cites W2132244795 @default.
• W2010559442 cites W2137074525 @default.
• W2010559442 cites W2169700552 @default.
• W2010559442 cites W2177327503 @default.
• W2010559442 doi "https://doi.org/10.1016/j.ygyno.2005.07.019" @default.
• W2010559442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16137749" @default.
• W2010559442 hasPublicationYear "2005" @default.
• W2010559442 type Work @default.
• W2010559442 sameAs 2010559442 @default.
• W2010559442 citedByCount "34" @default.
• W2010559442 countsByYear W20105594422012 @default.
• W2010559442 countsByYear W20105594422013 @default.
• W2010559442 countsByYear W20105594422014 @default.
• W2010559442 countsByYear W20105594422015 @default.
• W2010559442 countsByYear W20105594422016 @default.
• W2010559442 countsByYear W20105594422017 @default.
• W2010559442 countsByYear W20105594422018 @default.
• W2010559442 countsByYear W20105594422022 @default.
• W2010559442 countsByYear W20105594422023 @default.
• W2010559442 crossrefType "journal-article" @default.
• W2010559442 hasAuthorship W2010559442A5003016176 @default.
• W2010559442 hasAuthorship W2010559442A5011116669 @default.
• W2010559442 hasAuthorship W2010559442A5022837627 @default.
• W2010559442 hasAuthorship W2010559442A5029980930 @default.
• W2010559442 hasAuthorship W2010559442A5053347778 @default.
• W2010559442 hasAuthorship W2010559442A5054065628 @default.
• W2010559442 hasAuthorship W2010559442A5057817233 @default.
• W2010559442 hasAuthorship W2010559442A5058725877 @default.
• W2010559442 hasAuthorship W2010559442A5080823174 @default.
• W2010559442 hasConcept C121608353 @default.
• W2010559442 hasConcept C126322002 @default.
• W2010559442 hasConcept C147483822 @default.
• W2010559442 hasConcept C154317977 @default.
• W2010559442 hasConcept C167672396 @default.
• W2010559442 hasConcept C170627219 @default.
• W2010559442 hasConcept C202751555 @default.
• W2010559442 hasConcept C203014093 @default.
• W2010559442 hasConcept C2776090121 @default.
• W2010559442 hasConcept C2780427987 @default.
• W2010559442 hasConcept C39347974 @default.
• W2010559442 hasConcept C502942594 @default.
• W2010559442 hasConcept C54355233 @default.
• W2010559442 hasConcept C55493867 @default.
• W2010559442 hasConcept C67662055 @default.
• W2010559442 hasConcept C71924100 @default.
• W2010559442 hasConcept C81885089 @default.
• W2010559442 hasConcept C86803240 @default.
• W2010559442 hasConcept C8891405 @default.
• W2010559442 hasConcept C92488253 @default.
• W2010559442 hasConceptScore W2010559442C121608353 @default.
• W2010559442 hasConceptScore W2010559442C126322002 @default.
• W2010559442 hasConceptScore W2010559442C147483822 @default.
• W2010559442 hasConceptScore W2010559442C154317977 @default.
• W2010559442 hasConceptScore W2010559442C167672396 @default.
• W2010559442 hasConceptScore W2010559442C170627219 @default.
• W2010559442 hasConceptScore W2010559442C202751555 @default.
• W2010559442 hasConceptScore W2010559442C203014093 @default.
• W2010559442 hasConceptScore W2010559442C2776090121 @default.
• W2010559442 hasConceptScore W2010559442C2780427987 @default.
• W2010559442 hasConceptScore W2010559442C39347974 @default.
• W2010559442 hasConceptScore W2010559442C502942594 @default.
• W2010559442 hasConceptScore W2010559442C54355233 @default.
• W2010559442 hasConceptScore W2010559442C55493867 @default.
• W2010559442 hasConceptScore W2010559442C67662055 @default.
• W2010559442 hasConceptScore W2010559442C71924100 @default.
• W2010559442 hasConceptScore W2010559442C81885089 @default.
• W2010559442 hasConceptScore W2010559442C86803240 @default.
• W2010559442 hasConceptScore W2010559442C8891405 @default.

• next