Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010559992> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2010559992 endingPage "255" @default.
- W2010559992 startingPage "244" @default.
- W2010559992 abstract "Globular proteins have high packing densities as a result of residue side chains in the core achieving a tight, complementary packing. The internal packing is considered the main determinant of native protein structure. From that point of view, we present here a method of energy minimization using an automata network to predict a set of amino acid sequences and their side-chain conformations from a desired backbone geometry for de novo design of proteins. Using discrete side-chain conformations, that is, rotamers, the sequence generation problem from a given backbone geometry becomes one of combinatorial problems. We focused on the residues composing the interior core region and predicted a set of amino acid Sequences and their side-chain conformations only from a given backbone geometry. The kinds of residues were restricted to six hydrophobic amino acids (Ala, Ile, Met, Leu, Phe, and Val) because the core regions are almost always composed of hydrophobic residues. The obtained sequences were well packed as was the native sequence. The method can be used for automated sequence generation in the de novo design of proteins. © 1994 Wiley-Liss, Inc." @default.
- W2010559992 created "2016-06-24" @default.
- W2010559992 creator A5010686893 @default.
- W2010559992 creator A5080123389 @default.
- W2010559992 date "1994-07-01" @default.
- W2010559992 modified "2023-10-02" @default.
- W2010559992 title "Energy minimization method using automata network for sequence and side-chain conformation prediction from given backbone geometry" @default.
- W2010559992 cites W1574312817 @default.
- W2010559992 cites W157808733 @default.
- W2010559992 cites W1966041739 @default.
- W2010559992 cites W1970492002 @default.
- W2010559992 cites W1971182469 @default.
- W2010559992 cites W1971853518 @default.
- W2010559992 cites W1973284970 @default.
- W2010559992 cites W1976129314 @default.
- W2010559992 cites W1979046104 @default.
- W2010559992 cites W1979249166 @default.
- W2010559992 cites W1987630197 @default.
- W2010559992 cites W1989417429 @default.
- W2010559992 cites W1992739911 @default.
- W2010559992 cites W2013041880 @default.
- W2010559992 cites W2056412755 @default.
- W2010559992 cites W2086331976 @default.
- W2010559992 cites W2089958448 @default.
- W2010559992 cites W2091477689 @default.
- W2010559992 cites W2143967225 @default.
- W2010559992 cites W2158729487 @default.
- W2010559992 cites W2177731497 @default.
- W2010559992 cites W4230223507 @default.
- W2010559992 cites W4246356731 @default.
- W2010559992 doi "https://doi.org/10.1002/prot.340190308" @default.
- W2010559992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7937737" @default.
- W2010559992 hasPublicationYear "1994" @default.
- W2010559992 type Work @default.
- W2010559992 sameAs 2010559992 @default.
- W2010559992 citedByCount "41" @default.
- W2010559992 crossrefType "journal-article" @default.
- W2010559992 hasAuthorship W2010559992A5010686893 @default.
- W2010559992 hasAuthorship W2010559992A5080123389 @default.
- W2010559992 hasConcept C105168689 @default.
- W2010559992 hasConcept C121332964 @default.
- W2010559992 hasConcept C1276947 @default.
- W2010559992 hasConcept C147597530 @default.
- W2010559992 hasConcept C14961307 @default.
- W2010559992 hasConcept C152769699 @default.
- W2010559992 hasConcept C178790620 @default.
- W2010559992 hasConcept C18051474 @default.
- W2010559992 hasConcept C185592680 @default.
- W2010559992 hasConcept C199185054 @default.
- W2010559992 hasConcept C204328495 @default.
- W2010559992 hasConcept C204921945 @default.
- W2010559992 hasConcept C2524010 @default.
- W2010559992 hasConcept C2778112365 @default.
- W2010559992 hasConcept C33923547 @default.
- W2010559992 hasConcept C47701112 @default.
- W2010559992 hasConcept C521977710 @default.
- W2010559992 hasConcept C55493867 @default.
- W2010559992 hasConcept C8010536 @default.
- W2010559992 hasConceptScore W2010559992C105168689 @default.
- W2010559992 hasConceptScore W2010559992C121332964 @default.
- W2010559992 hasConceptScore W2010559992C1276947 @default.
- W2010559992 hasConceptScore W2010559992C147597530 @default.
- W2010559992 hasConceptScore W2010559992C14961307 @default.
- W2010559992 hasConceptScore W2010559992C152769699 @default.
- W2010559992 hasConceptScore W2010559992C178790620 @default.
- W2010559992 hasConceptScore W2010559992C18051474 @default.
- W2010559992 hasConceptScore W2010559992C185592680 @default.
- W2010559992 hasConceptScore W2010559992C199185054 @default.
- W2010559992 hasConceptScore W2010559992C204328495 @default.
- W2010559992 hasConceptScore W2010559992C204921945 @default.
- W2010559992 hasConceptScore W2010559992C2524010 @default.
- W2010559992 hasConceptScore W2010559992C2778112365 @default.
- W2010559992 hasConceptScore W2010559992C33923547 @default.
- W2010559992 hasConceptScore W2010559992C47701112 @default.
- W2010559992 hasConceptScore W2010559992C521977710 @default.
- W2010559992 hasConceptScore W2010559992C55493867 @default.
- W2010559992 hasConceptScore W2010559992C8010536 @default.
- W2010559992 hasIssue "3" @default.
- W2010559992 hasLocation W20105599921 @default.
- W2010559992 hasLocation W20105599922 @default.
- W2010559992 hasOpenAccess W2010559992 @default.
- W2010559992 hasPrimaryLocation W20105599921 @default.
- W2010559992 hasRelatedWork W1981069567 @default.
- W2010559992 hasRelatedWork W1994983243 @default.
- W2010559992 hasRelatedWork W2010559992 @default.
- W2010559992 hasRelatedWork W2012919871 @default.
- W2010559992 hasRelatedWork W2038819579 @default.
- W2010559992 hasRelatedWork W2074157044 @default.
- W2010559992 hasRelatedWork W2171412811 @default.
- W2010559992 hasRelatedWork W2494604670 @default.
- W2010559992 hasRelatedWork W4238154023 @default.
- W2010559992 hasRelatedWork W784872487 @default.
- W2010559992 hasVolume "19" @default.
- W2010559992 isParatext "false" @default.
- W2010559992 isRetracted "false" @default.
- W2010559992 magId "2010559992" @default.
- W2010559992 workType "article" @default.